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Il9r  -  interleukin 9 receptor

Mus musculus

Synonyms: IL-9 receptor, IL-9R, Interleukin-9 receptor
 
 
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Disease relevance of Il9r

  • Mutations in the common gamma chain (gamma c) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. gamma c contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R [1].
  • Finally, using IL-9R-deficient mice, we found that despite its anaphylaxis-promoting activity, IL-9 is dispensable for development of both passive and active anaphylaxis, at least in the C57BL/6 mouse background [2].
 

High impact information on Il9r

  • In normal mice, the IL-9 receptor was found to be expressed by CD5(+) as well as CD5(-) B-1 cells, and repeated injections of IL-9 resulted in accumulation of B-1 cells in the peritoneal cavity, as observed in transgenic animals [3].
  • A cDNA clone encoding the murine IL-9 receptor was isolated by expression cloning in COS cells and screening with 125I-labeled IL-9 [4].
  • This finding raises the question of how the transcriptional regulation of genes within Xq PAR occurs and how the X inactivation status of IL9R has evolved following the autosome to X and the X to X/Y translocation [5].
  • The evolutionary analysis of the IL9R gene, which is located at 10 kb from the telomere, and its pseudogenes at several telomeres, also provides insight into the evolution of these loci and of subtelomeric regions in general [5].
  • In contrast, we show that IL9R expression does occur from the Y, the active and the inactive X chromosomes [5].
 

Biological context of Il9r

 

Anatomical context of Il9r

  • Elevated interleukin-9 receptor expression and response to interleukins-9 and -7 in thymocytes during radiation-induced T-cell lymphomagenesis in B6C3F1 mice [10].
  • In addition, primary cultured ASM cells, as well as bronchial smooth muscle cells within biopsies of asthmatics and not control subjects, revealed IL-9R protein expression [11].
  • The lymphocyte IL-2Rgamma, an essential subunit for IL-2 signaling, is also a common subunit (gammac) for multiple immune cytokine receptors (e.g., IL-4R, IL-7R, IL-9R, IL-15R) [12].
 

Other interactions of Il9r

  • In this study we provide the first evidence that non-tyrosine kinase-type cytokine surface receptors, IL-9R alpha-chain, IL-2 receptor ss-chain, and erythropoietin receptor, can be polyubiquitinated and degraded by proteasomes [13].
 

Analytical, diagnostic and therapeutic context of Il9r

  • Sequence analysis revealed that the IL-9 receptor belongs to the recently described hematopoietin receptor super-family and is expressed in membrane-bound and soluble forms [4].

References

  1. Multiple gamma c-dependent cytokines regulate T-cell development. Malek, T.R., Porter, B.O., He, Y.W. Immunol. Today (1999) [Pubmed]
  2. IL-9 promotes but is not necessary for systemic anaphylaxis. Knoops, L., Louahed, J., Van Snick, J., Renauld, J.C. J. Immunol. (2005) [Pubmed]
  3. Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population. Vink, A., Warnier, G., Brombacher, F., Renauld, J.C. J. Exp. Med. (1999) [Pubmed]
  4. Expression cloning of the murine and human interleukin 9 receptor cDNAs. Renauld, J.C., Druez, C., Kermouni, A., Houssiau, F., Uyttenhove, C., Van Roost, E., Van Snick, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y. Vermeesch, J.R., Petit, P., Kermouni, A., Renauld, J.C., Van Den Berghe, H., Marynen, P. Hum. Mol. Genet. (1997) [Pubmed]
  6. Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. Demoulin, J.B., Van Roost, E., Stevens, M., Groner, B., Renauld, J.C. J. Biol. Chem. (1999) [Pubmed]
  7. Critical cytoplasmic domains of human interleukin-9 receptor alpha chain in interleukin-9-mediated cell proliferation and signal transduction. Zhu, Y.X., Sun, H.B., Tsang, M.L., McMahel, J., Grigsby, S., Yin, T., Yang, Y.C. J. Biol. Chem. (1997) [Pubmed]
  8. Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor. Tsukadaira, A., Okubo, Y., Koyama, S., Sato, E., Nagase, H., Agematsu, K., Nakazawa, K. Exp. Lung Res. (2002) [Pubmed]
  9. Induction of interleukin-2 receptor alpha (IL-2Ralpha) expression by interleukin-2: important role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites. Imbert, V., Rezzonico, R., Reichenbach, P., Nabholz, M. Eur. Cytokine Netw. (2002) [Pubmed]
  10. Elevated interleukin-9 receptor expression and response to interleukins-9 and -7 in thymocytes during radiation-induced T-cell lymphomagenesis in B6C3F1 mice. Nishimura, M., Kakinuma, S., Yamamoto, D., Kobayashi, Y., Suzuki, G., Sado, T., Shimada, Y. J. Cell. Physiol. (2004) [Pubmed]
  11. IL-9-mediated induction of eotaxin1/CCL11 in human airway smooth muscle cells. Gounni, A.S., Hamid, Q., Rahman, S.M., Hoeck, J., Yang, J., Shan, L. J. Immunol. (2004) [Pubmed]
  12. Molecular cloning of the cDNA coding sequence of IL-2 receptor-gamma (gammac) from human and murine forebrain: expression in the hippocampus in situ and by brain cells in vitro. Petitto, J.M., Huang, Z., Raizada, M.K., Rinker, C.M., McCarthy, D.B. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  13. Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin. Yen, C.H., Yang, Y.C., Ruscetti, S.K., Kirken, R.A., Dai, R.M., Li, C.C. J. Immunol. (2000) [Pubmed]
 
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