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Gene Review

IL9R  -  interleukin 9 receptor

Homo sapiens

Synonyms: CD129, IL-9 receptor, IL-9R, Interleukin-9 receptor
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Disease relevance of IL9R


Psychiatry related information on IL9R

  • In this investigation, we analysed a polymorphic CAG repeat in the interleukin receptor gene (IL9R), mapped to the pseudoautosomal region Xq28 and Yq21 (a candidate region for schizophrenia and affective disorder) [4].

High impact information on IL9R


Biological context of IL9R


Anatomical context of IL9R

  • Analysis of IL-9R alpha subunit expression on 18 T cell clones revealed that IL-9 responsiveness was directly proportional to the expression of the high-affinity receptor [11].
  • Expression of hCLCA1 mRNA was colocalised with IL-9R expression and PAS-positive staining in epithelial cells [12].
  • IL-9 responsiveness was also dependent on long-term culturing because neither freshly isolated nor 3-day phytohemagglutinin (PHA)-stimulated peripheral blood lymphocytes (PBL) expressed IL-9R alpha [11].
  • In summary, the data showed that IL-9 can rescue only a small subset of Th2 cells from apoptosis induced by growth factor withdrawal and that expression of IL-9R alpha is required for the antiapoptotic signals mediated by this cytokine [11].
  • Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release [13].

Associations of IL9R with chemical compounds

  • Taken together, these data indicate that a single tyrosine of the IL-9 receptor, required for activation of three different STAT proteins, is necessary for distinct activities of this cytokine, including proliferative responses [14].
  • We constructed a retroviral vector, pLhIL-9RSN, containing CDNA encoding the human interleukin-9 receptor (IL-9R) along with a neomycin phosphotransferase gene (Neo) [15].

Physical interactions of IL9R


Regulatory relationships of IL9R

  • The data demonstrate that myeloid progenitors can be transduced at the single-cell level with both hEpoR and hIL-9R genes with resultant enhanced proliferation of these progenitors in the erythroid lineage by combinations of cytokines including Epo and IL-9 [18].

Other interactions of IL9R

  • Surprisingly, in a substantial part of the myeloid lineage cells examined, an IL-2Rgamma+, IL-4R-, IL7R- configuration was noted that was, however, frequently associated with expression of IL-9R [17].
  • Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y [19].
  • IL-4R and PRLR gave only small numbers of thymocytes, whereas IL-9R gave robust alphabeta T cell development and reconstitution of peripheral CD4 and CD8 cells, indicating that it can duplicate many of the functions of IL-7R [20].
  • Neutralizing monoclonal antibodies (mAbs) for IL-9 receptor and c-kit completely abolished this synergistic effect [21].
  • Influence of retroviral-mediated gene transduction of both the recombinant human erythropoietin receptor and interleukin-9 receptor genes into single CD34++CD33-or low cord blood cells on cytokine-stimulated erythroid colony formation [18].

Analytical, diagnostic and therapeutic context of IL9R


  1. A deletion mutant of Pseudomonas exotoxin-A fused to recombinant human interleukin-9 (rhIL-9-ETA') shows specific cytotoxicity against IL-9-receptor-expressing cell lines. Klimka, A., Barth, S., Drillich, S., Wels, W., van Snick, J., Renauld, J.C., Tesch, H., Bohlen, H., Diehl, V., Engert, A. Cytokines and molecular therapy. (1996) [Pubmed]
  2. Cis/trans-activation of the interleukin-9 receptor gene in an HTLV-I-transformed human lymphocytic cell. Kubota, S., Siomi, H., Hatanaka, M., Pomerantz, R.J. Oncogene (1996) [Pubmed]
  3. Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis. Flubacher, M.M., Bear, S.E., Tsichlis, P.N. J. Virol. (1994) [Pubmed]
  4. Pseudoautosomal gene: possible association with bipolar males but not with schizophrenia. Hawi, Z., Mynett-Johnson, L., Gill, M., Murphy, V., Straubl, R.E., Kendler, K.S., Walsh, D., Machen, F., Connell, H., McKeon, P., Shields, D. Psychiatr. Genet. (1999) [Pubmed]
  5. Human intestinal epithelial cells express functional cytokine receptors sharing the common gamma c chain of the interleukin 2 receptor. Reinecker, H.C., Podolsky, D.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. Ciccodicola, A., D'Esposito, M., Esposito, T., Gianfrancesco, F., Migliaccio, C., Miano, M.G., Matarazzo, M.R., Vacca, M., Franzè, A., Cuccurese, M., Cocchia, M., Curci, A., Terracciano, A., Torino, A., Cocchia, S., Mercadante, G., Pannone, E., Archidiacono, N., Rocchi, M., Schlessinger, D., D'Urso, M. Hum. Mol. Genet. (2000) [Pubmed]
  7. Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils. Gounni, A.S., Gregory, B., Nutku, E., Aris, F., Latifa, K., Minshall, E., North, J., Tavernier, J., Levit, R., Nicolaides, N., Robinson, D., Hamid, Q. Blood (2000) [Pubmed]
  8. Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study. Mel??n, E., Umerkajeff, S., Nyberg, F., Zucchelli, M., Lindstedt, A., Gullst??n, H., Wickman, M., Pershagen, G., Kere, J. Clin. Exp. Allergy (2006) [Pubmed]
  9. Isolation and characterization of the human interleukin-9 receptor gene. Chang, M.S., Engel, G., Benedict, C., Basu, R., McNinch, J. Blood (1994) [Pubmed]
  10. Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis. Bauer, J.H., Liu, K.D., You, Y., Lai, S.Y., Goldsmith, M.A. J. Biol. Chem. (1998) [Pubmed]
  11. Rescue of human T cells by interleukin-9 (IL-9) from IL-2 deprivation-induced apoptosis: correlation with alpha subunit expression of the IL-9 receptor. Perdow-Hickman, S., Salgame, P. J. Interferon Cytokine Res. (2000) [Pubmed]
  12. Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. Hauber, H.P., Tsicopoulos, A., Wallaert, B., Griffin, S., McElvaney, N.G., Daigneault, P., Mueller, Z., Olivenstein, R., Holroyd, K.J., Levitt, R.C., Hamid, Q. Eur. Respir. J. (2004) [Pubmed]
  13. Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release. Abdelilah, S., Latifa, K., Esra, N., Cameron, L., Bouchaib, L., Nicolaides, N., Levitt, R., Hamid, Q. J. Immunol. (2001) [Pubmed]
  14. A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Demoulin, J.B., Uyttenhove, C., Van Roost, E., DeLestré, B., Donckers, D., Van Snick, J., Renauld, J.C. Mol. Cell. Biol. (1996) [Pubmed]
  15. Transduction of human interleukin-9 receptor gene into human cord blood erythroid progenitors increases the number of erythropoietin-dependent erythroid colonies. Xiao, M., Yang, Y.C., Yang, L., Chang, M.S., Cornetta, K., Broxymeyer, H.E., Lu, L. Bone Marrow Transplant. (1996) [Pubmed]
  16. Tip60 interacts with human interleukin-9 receptor alpha-chain. Sliva, D., Zhu, Y.X., Tsai, S., Kamine, J., Yang, Y.C. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  17. Transcript synthesis and surface expression of the interleukin-2 receptor (alpha-, beta-, and gamma-chain) by normal and malignant myeloid cells. Schumann, R.R., Nakarai, T., Gruss, H.J., Brach, M.A., von Arnim, U., Kirschning, C., Karawajew, L., Ludwig, W.D., Renauld, J.C., Ritz, J., Herrmann, F. Blood (1996) [Pubmed]
  18. Influence of retroviral-mediated gene transduction of both the recombinant human erythropoietin receptor and interleukin-9 receptor genes into single CD34++CD33-or low cord blood cells on cytokine-stimulated erythroid colony formation. Lu, L., Ge, Y., Li, Z.H., Xiao, M., Broxmeyer, H.E. Exp. Hematol. (1996) [Pubmed]
  19. Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. D'Esposito, M., Matarazzo, M.R., Ciccodicola, A., Strazzullo, M., Mazzarella, R., Quaderi, N.A., Fujiwara, H., Ko, M.S., Rowe, L.B., Ricco, A., Archidiacono, N., Rocchi, M., Schlessinger, D., D'Urso, M. Hum. Mol. Genet. (1997) [Pubmed]
  20. Role of the Intracellular Domain of IL-7 Receptor in T Cell Development. Jiang, Q., Huang, J., Li, W.Q., Cavinato, T., Keller, J.R., Durum, S.K. J. Immunol. (2007) [Pubmed]
  21. Role of human interleukin-9 as a megakaryocyte potentiator in culture. Fujiki, H., Kimura, T., Minamiguchi, H., Harada, S., Wang, J., Nakao, M., Yokota, S., Urata, Y., Ueda, Y., Yamagishi, H., Sonoda, Y. Exp. Hematol. (2002) [Pubmed]
  22. The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter. Kermouni, A., Van Roost, E., Arden, K.C., Vermeesch, J.R., Weiss, S., Godelaine, D., Flint, J., Lurquin, C., Szikora, J.P., Higgs, D.R. Genomics (1995) [Pubmed]
  23. Expression of interleukin-9 in nasal natural killer/T-cell lymphoma cell lines and patients. Nagato, T., Kobayashi, H., Kishibe, K., Takahara, M., Ogino, T., Ishii, H., Oikawa, K., Aoki, N., Sato, K., Kimura, S., Shimizu, N., Tateno, M., Harabuchi, Y. Clin. Cancer Res. (2005) [Pubmed]
  24. Interleukin-9 (IL-9) induces cell growth arrest associated with sustained signal transducer and activator of transcription activation in lymphoma cells overexpressing the IL-9 receptor. Demoulin, J.B., Van Snick, J., Renauld, J.C. Cell Growth Differ. (2001) [Pubmed]
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