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Gene Review

DCTN1  -  dynactin 1

Homo sapiens

Synonyms: 150 kDa dynein-associated polypeptide, DAP-150, DP-150, Dynactin subunit 1, P135, ...
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Disease relevance of DCTN1


High impact information on DCTN1


Biological context of DCTN1


Associations of DCTN1 with chemical compounds

  • However, polymers of P135 -155 (prepared by linking to diaminoalkanes ) and synthetic conjugates prepared by binding P135 -155 to liposomes or polylysine were immunogenic [3].
  • In order to prepare CEAs successfully, the concentrations of NP10 and P135 should be in 1.5-3.0% (w/v) and 0.25-1.0% (w/v), respectively, together with the ratio of the volume of oil phase to the volume of inner aqueous phase of CEAs, R(oi)> or =1:1 [10].

Physical interactions of DCTN1

  • To test directly and rigorously the hypothesis that dynactin is required to attach dynein to membranes, we used both a Drosophila mutant and RNA interference to generate organisms and cells lacking the critical dynactin subunit, actin-related protein 1 [11].

Other interactions of DCTN1

  • This information should allow the study of potential genomic alterations of DCTN1-SLC4A5 in patients with diseases mapping to this genomic region [8].
  • The allelic variants of the DCTN1 gene may represent a previously unknown genomic risk factor for ALS [12].
  • P-135-ABP also enhanced the depolymerization of actin filaments during dilution-mediated disassembly [13].
  • Plant villin, lily P-135-ABP, possesses G-actin binding activity and accelerates the polymerization and depolymerization of actin in a Ca2+-sensitive manner [13].


  1. Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD. Münch, C., Rosenbohm, A., Sperfeld, A.D., Uttner, I., Reske, S., Krause, B.J., Sedlmeier, R., Meyer, T., Hanemann, C.O., Stumm, G., Ludolph, A.C. Ann. Neurol. (2005) [Pubmed]
  2. The genomic structure of DCTN1, a candidate gene for limb-girdle muscular dystrophy (LGMD2B). Tokito, M.K., Holzbaur, E.L. Biochim. Biophys. Acta (1998) [Pubmed]
  3. Antibodies to hepatitis B surface antigen (HBsAg) elicited by immunization with a synthetic peptide covalently linked to liposomes. Neurath, A.R., Kent, S.B., Strick, N. J. Gen. Virol. (1984) [Pubmed]
  4. Calcium-calmodulin suppresses the filamentous actin-binding activity of a 135-kilodalton actin-bundling protein isolated from lily pollen tubes. Yokota, E., Muto, S., Shimmen, T. Plant Physiol. (2000) [Pubmed]
  5. Preparation of a stable double emulsion (W1/O/W2): role of the interfacial films on the stability of the system. Kanouni, M., Rosano, H.L., Naouli, N. Advances in colloid and interface science. (2002) [Pubmed]
  6. Human DCTN1: genomic structure and evaluation as a candidate for Alström syndrome. Collin, G.B., Nishina, P.M., Marshall, J.D., Naggert, J.K. Genomics (1998) [Pubmed]
  7. Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization. Holzbaur, E.L., Tokito, M.K. Genomics (1996) [Pubmed]
  8. Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued). Pushkin, A., Abuladze, N., Newman, D., Tatishchev, S., Kurtz, I. Cytogenet. Cell Genet. (2001) [Pubmed]
  9. Mouse p150Glued (dynactin 1) cDNA sequence and evaluation as a candidate for the neuromuscular disease mutation mnd2. Jang, W., Weber, J.S., Tokito, M.K., Holzbaur, E.L., Meisler, M.H. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  10. In vitro studies on the application of colloidal emulsion aphrons to drug overdose treatment. Dai, Y., Deng, T., Lu, F. International journal of pharmaceutics. (2006) [Pubmed]
  11. Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Haghnia, M., Cavalli, V., Shah, S.B., Schimmelpfeng, K., Brusch, R., Yang, G., Herrera, C., Pilling, A., Goldstein, L.S. Mol. Biol. Cell (2007) [Pubmed]
  12. Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS. Münch, C., Sedlmeier, R., Meyer, T., Homberg, V., Sperfeld, A.D., Kurt, A., Prudlo, J., Peraus, G., Hanemann, C.O., Stumm, G., Ludolph, A.C. Neurology (2004) [Pubmed]
  13. Plant villin, lily P-135-ABP, possesses G-actin binding activity and accelerates the polymerization and depolymerization of actin in a Ca2+-sensitive manner. Yokota, E., Tominaga, M., Mabuchi, I., Tsuji, Y., Staiger, C.J., Oiwa, K., Shimmen, T. Plant Cell Physiol. (2005) [Pubmed]
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