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Gene Review

NUDT10  -  nudix (nucleoside diphosphate linked...

Homo sapiens

Synonyms: APS2, DIPP-3-alpha, DIPP3-alpha, DIPP3A, DIPP3a, ...
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Disease relevance of NUDT10


High impact information on NUDT10

  • Conclusion: Our data show that peripheral lymphocytes of subjects affected by thyroid autoimmunity or APS-2 show defective expression of the major executioner of AICD, thus potentially contributing to AICD resistance and to the development of autoimmunity [6].
  • In this anion-exchange "high-performance" liquid-chromatographic method of analysis for purine nucleotides, the nucleotides are separated with high efficiency and selectivity on a weak anion exchanger (Hypersil APS 2, 3-micron particle size) by elution with a gradient of eluent pH and concentration [7].
  • The chromatography was performed using a Thermo Hypersil APS-2 Amino column (250 mm x 4.6 mm, 5 microm) with a mobile phase consisting of acetonitrile and 0.4% glacial acetic acid in water (20:80) [8].
  • Our results show that patients with Addison's disease in association with APS2 or Addison's disease as an isolated form share highly similar MHC class II and class III alleles [9].
  • The patient group was divided into two subgroups: APS-1 with warfarin treatment, and APS-2 without warfarin treatment [10].

Biological context of NUDT10


Associations of NUDT10 with chemical compounds

  • Both hAps1 and hAps2 had pH optima of 8.5 and an absolute requirement for divalent cations, with manganese (II) being favoured [11].


  1. Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE-1) genes in sporadic autoimmune Addison's disease. Vaidya, B., Imrie, H., Geatch, D.R., Perros, P., Ball, S.G., Baylis, P.H., Carr, D., Hurel, S.J., James, R.A., Kelly, W.F., Kemp, E.H., Young, E.T., Weetman, A.P., Kendall-Taylor, P., Pearce, S.H. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  2. Update on autoimmune polyendocrine syndromes (APS). Betterle, C., Zanchetta, R. Acta bio-medica de L'Ateneo parmense : organo della Società di medicina e scienze naturali di Parma. (2003) [Pubmed]
  3. Adrenal autoimmunity: results and developments. Peterson, P., Uibo, R., Krohn, K.J. Trends Endocrinol. Metab. (2000) [Pubmed]
  4. Autoimmune hypogonadism as part of an autoimmune polyglandular syndrome. Maclaren, N., Chen, Q.Y., Kukreja, A., Marker, J., Zhang, C.H., Sun, Z.S. J. Soc. Gynecol. Investig. (2001) [Pubmed]
  5. Autoimmune polyglandular syndromes. Obermayer-Straub, P., Manns, M.P. Baillieres Clin. Gastroenterol. (1998) [Pubmed]
  6. Impaired caspase-3 expression by peripheral T cells in chronic autoimmune thyroiditis and in autoimmune polyendocrine syndrome-2. Vendrame, F., Segni, M., Grassetti, D., Tellone, V., Augello, G., Trischitta, V., Torlontano, M., Dotta, F. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  7. Liquid-chromatographic measurement of purine nucleotides in blood cells. Boulieu, R., Bory, C., Gonnet, C. Clin. Chem. (1985) [Pubmed]
  8. Simultaneous determination of paracetamol and dextropropoxyphene in human plasma by liquid chromatography/tandem mass spectrometry: application to clinical bioequivalence studies. Yin, O.Q., Lam, S.S., Chow, M.S. Rapid Commun. Mass Spectrom. (2005) [Pubmed]
  9. Major histocompatibility complex class II and III in Addison's disease. MHC alleles do not predict autoantibody specificity and 21-hydroxylase gene polymorphism has no independent role in disease susceptibility. Partanen, J., Peterson, P., Westman, P., Aranko, S., Krohn, K. Hum. Immunol. (1994) [Pubmed]
  10. Arterial compliance: is it reduced in antiphospholipid syndrome? Reitblat, T., Polishchuk, I., Zamir, D., Isakov, I., Oren, S. Journal of human hypertension. (2006) [Pubmed]
  11. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. Leslie, N.R., McLennan, A.G., Safrany, S.T. BMC Biochem. (2002) [Pubmed]
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