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Gene Review

NUDT11  -  nudix (nucleoside diphosphate linked...

Homo sapiens

Synonyms: APS1, ASP1, DIPP-3-beta, DIPP3-beta, DIPP3B, ...
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Disease relevance of NUDT11


High impact information on NUDT11

  • It is likely that sporadic (non-APS1) AAD is inherited as a complex trait; however, apart from the major histocompatibility complex, the susceptibility genes remain unknown [1].
  • In contrast, the mutant AIRE-1 964del13 allele was carried in one each of the 576 (0.2%) control subjects and the 90 (1.1%) AAD subjects as a heterozygote (P = 0.254, not significant), suggesting that this common AIRE-1 gene abnormality does not have a major role in sporadic (non-APS1) AAD [1].
  • The predicted APS1 protein contains two domains: an N-terminal catalytic domain, and a C-terminal hydrophobic domain [5].
  • An alpha-glucosidase, referred to as APS1, was identified in both a gut-specific cDNA library and a sucrase-enriched membrane preparation from guts of the pea aphid Acyrthosiphon pisum by a combination of genomic and proteomic techniques [5].
  • Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. chinensis [2].

Biological context of NUDT11


Associations of NUDT11 with chemical compounds


Other interactions of NUDT11


Analytical, diagnostic and therapeutic context of NUDT11

  • In situ localisation and RT-PCR studies revealed that APS1 mRNA was expressed in the gut distal to the stomach, the same localisation as sucrase activity [5].


  1. Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE-1) genes in sporadic autoimmune Addison's disease. Vaidya, B., Imrie, H., Geatch, D.R., Perros, P., Ball, S.G., Baylis, P.H., Carr, D., Hurel, S.J., James, R.A., Kelly, W.F., Kemp, E.H., Young, E.T., Weetman, A.P., Kendall-Taylor, P., Pearce, S.H. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  2. Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. chinensis. Wu, J.H., Xu, C., Shan, C.Y., Tan, R.X. Life Sci. (2006) [Pubmed]
  3. Ocular complications of autoimmune polyendocrinopathy syndrome type 1. Chang, B., Brosnahan, D., McCreery, K., Dominguez, M., Costigan, C. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus (2006) [Pubmed]
  4. Prevalence and epidemiology of autoimmune hepatitis. Boberg, K.M. Clinics in liver disease. (2002) [Pubmed]
  5. Molecular characterisation of a candidate gut sucrase in the pea aphid, Acyrthosiphon pisum. Price, D.R., Karley, A.J., Ashford, D.A., Isaacs, H.V., Pownall, M.E., Wilkinson, H.S., Gatehouse, J.A., Douglas, A.E. Insect Biochem. Mol. Biol. (2007) [Pubmed]
  6. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. Leslie, N.R., McLennan, A.G., Safrany, S.T. BMC Biochem. (2002) [Pubmed]
  7. Mass-spectrometric identification of a novel angiotensin peptide in human plasma. Jankowski, V., Vanholder, R., van der Giet, M., Tölle, M., Karadogan, S., Gobom, J., Furkert, J., Oksche, A., Krause, E., Tran, T.N., Tepel, M., Schuchardt, M., Schlüter, H., Wiedon, A., Beyermann, M., Bader, M., Todiras, M., Zidek, W., Jankowski, J. Arterioscler. Thromb. Vasc. Biol. (2007) [Pubmed]
  8. Update on autoimmune polyendocrine syndromes (APS). Betterle, C., Zanchetta, R. Acta bio-medica de L'Ateneo parmense : organo della Società di medicina e scienze naturali di Parma. (2003) [Pubmed]
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