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Gene Review

Mafk  -  v-maf musculoaponeurotic fibrosarcoma...

Mus musculus

Synonyms: AW061068, Erythroid transcription factor NF-E2 p18 subunit, NF-E2, Nfe2u, Transcription factor MafK, ...
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Disease relevance of Mafk

  • Taken together, these results provide direct evidence that NF-E2 gene is essential for globin transcription and suggest that perturbation in expression of this transcription factor may contribute to erythroleukemia progression [1].
  • Thus, a quantitative embryonic platelet defect (severe thrombopenia secondary to NF-E2 deficiency) is associated with an embryonic growth retardation and reduced vascularisation of the placenta [2].

High impact information on Mafk


Biological context of Mafk


Anatomical context of Mafk

  • Here we present evidence that the large subunit of mammalian NF-E2, p45, is sumoylated in vivo in human erythroid K562 cells and in mouse fetal liver [9].
  • These data together point to a model of mammalian beta-like globin gene activation by sumoylated p45/NF-E2 in erythroid cells [9].

Other interactions of Mafk

  • Mutational studies further demonstrated that NF-E2/AP-1 and Sp1 exerted activating and repressive, respectively, effects on the promoter [10].

Analytical, diagnostic and therapeutic context of Mafk

  • Preparative electrophoretic mobility shift assays coupled to Western analysis identified NF-E2-related proteins 1 and 2 and JunD in complexes assembled on AREs [11].


  1. Retroviral integration within the Fli-2 locus results in inactivation of the erythroid transcription factor NF-E2 in Friend erythroleukemias: evidence that NF-E2 is essential for globin expression. Lu, S.J., Rowan, S., Bani, M.R., Ben-David, Y. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. The role of platelets during reproduction. Isermann, B., Nawroth, P.P. Pathophysiol. Haemost. Thromb. (2006) [Pubmed]
  3. Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus. Kotkow, K.J., Orkin, S.H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Conditional expression of the ubiquitous transcription factor MafK induces erythroleukemia cell differentiation. Igarashi, K., Itoh, K., Hayashi, N., Nishizawa, M., Yamamoto, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. McCormack, M.P., Hall, M.A., Schoenwaelder, S.M., Zhao, Q., Ellis, S., Prentice, J.A., Clarke, A.J., Slater, N.J., Salmon, J.M., Jackson, S.P., Jane, S.M., Curtis, D.J. Blood (2006) [Pubmed]
  6. The ubiquitous subunit of the globin enhancer-binding protein NF-E2 (Nfe2u) maps to mouse chromosome 5. Peters, L.L., Eicher, E.M. Genomics (1994) [Pubmed]
  7. The world according to Maf. Motohashi, H., Shavit, J.A., Igarashi, K., Yamamoto, M., Engel, J.D. Nucleic Acids Res. (1997) [Pubmed]
  8. Multiple factors regulating the expression of human thromboxane synthase gene. Lee, K.D., Baek, S.J., Shen, R.F. Biochem. J. (1996) [Pubmed]
  9. Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus. Shyu, Y.C., Lee, T.L., Ting, C.Y., Wen, S.C., Hsieh, L.J., Li, Y.C., Hwang, J.L., Lin, C.C., Shen, C.K. Mol. Cell. Biol. (2005) [Pubmed]
  10. Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene. Zhang, L., Xiao, H., Schultz, R.A., Shen, R.F. Genomics (1997) [Pubmed]
  11. Identification of albumin precursor protein, Phi AP3, and alpha-smooth muscle actin as novel components of redox sensing machinery in vascular smooth muscle cells. Holderman, M.T., Miller, K.P., Dangott, L.J., Ramos, K.S. Mol. Pharmacol. (2002) [Pubmed]
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