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Gene Review

Mapkapk5  -  MAP kinase-activated protein kinase 5

Mus musculus

Synonyms: MAPK-activated protein kinase 5, MAPKAP kinase 5, MAPKAPK-5, MK5, PRAK
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High impact information on Mapkapk5

  • However, relatively little is known about the signaling pathways mediating the senescence response. p38-regulated/activated protein kinase (PRAK) is a p38 MAPK substrate whose physiological functions are poorly understood [1].
  • In primary cells, inactivation of PRAK prevents senescence and promotes oncogenic transformation [1].
  • Furthermore, we show that PRAK activates p53 by direct phosphorylation [1].
  • There are currently 11 vertebrate MKs in five subfamilies based on primary sequence homology: the ribosomal S6 kinases, the mitogen- and stress-activated kinases, the MAPK-interacting kinases, MAPK-activated protein kinases 2 and 3, and MK5 [2].
  • Endogenous MK5 activity is significantly reduced by siRNA-mediated knockdown of ERK3 and also in fibroblasts derived from ERK3-/- mice [3].

Biological context of Mapkapk5

  • Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway [3].
  • We conclude that the differences between the phenotypes of MK5- and MK2-deficient mice result from clearly different functional properties of both enzymes [4].
  • To explain this discrepancy, we used wild-type cells and embryonic fibroblasts from both MK2 and MK5 knockout mice as controls to reexamine the mechanism of activation, the interaction with endogenous p38 MAPK, and the substrate specificity of both enzymes [4].
  • In mouse embryonic development, mRNA expression patterns of ERK3 and MK5 suggest spatiotemporal coexpression of both kinases [5].
  • Furthermore, we have shown that the C-terminal domain of MK5 contains both a functional nuclear localization signal (NLS) and a leucine-rich nuclear export signal (NES), indicating that the subcellular distribution of this kinase reflects the relative activities of these two signals [6].

Anatomical context of Mapkapk5

  • Furthermore, increased levels of ERK3 protein detected during nerve growth factor-induced differentiation of PC12 cells are accompanied by an increase in MK5 activity [3].
  • We demonstrate that the distribution of Hsp25 and MK5 in the epidermis at the beginning of stratification and before keratinization is similar to that observed in PAM212 keratinocytes [7].
  • Analysis of urine function of PRAKP mice reveals an unexpected P-dependent proliferative activity of PR-B in the epithelium and provides evidence that the tissue-specific reproductive effects of this isoform are due to specificity of target gene transactivation rather than differences in tissue-specific expression relative to PR-A [8].

Associations of Mapkapk5 with chemical compounds


Enzymatic interactions of Mapkapk5


Regulatory relationships of Mapkapk5

  • In support of this, we have shown that stress-induced activation of the p38 MAPK stimulates the chromosomal region maintenance 1 protein-dependent nuclear export of MK5 [6].


  1. PRAK Is Essential for ras-Induced Senescence and Tumor Suppression. Sun, P., Yoshizuka, N., New, L., Moser, B.A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., Dong, M.Q., Frangou, C.G., Yates, J.R., Wright, P.E., Han, J. Cell (2007) [Pubmed]
  2. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Roux, P.P., Blenis, J. Microbiol. Mol. Biol. Rev. (2004) [Pubmed]
  3. Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. Seternes, O.M., Mikalsen, T., Johansen, B., Michaelsen, E., Armstrong, C.G., Morrice, N.A., Turgeon, B., Meloche, S., Moens, U., Keyse, S.M. EMBO J. (2004) [Pubmed]
  4. Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination. Shi, Y., Kotlyarov, A., Laabeta, K., Gruber, A.D., Butt, E., Marcus, K., Meyer, H.E., Friedrich, A., Volk, H.D., Gaestel, M. Mol. Cell. Biol. (2003) [Pubmed]
  5. Scaffolding by ERK3 regulates MK5 in development. Schumacher, S., Laass, K., Kant, S., Shi, Y., Visel, A., Gruber, A.D., Kotlyarov, A., Gaestel, M. EMBO J. (2004) [Pubmed]
  6. Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress. Seternes, O.M., Johansen, B., Hegge, B., Johannessen, M., Keyse, S.M., Moens, U. Mol. Cell. Biol. (2002) [Pubmed]
  7. Heat shock protein 25 plays multiple roles during mouse skin development. Duverger, O., Morange, M. Cell Stress Chaperones (2005) [Pubmed]
  8. Reproductive functions of the progesterone receptor isoforms: lessons from knock-out mice. Conneely, O.M., Mulac-Jericevic, B., Lydon, J.P., De Mayo, F.J. Mol. Cell. Endocrinol. (2001) [Pubmed]
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