Gene Review:
Numb - numb gene homolog (Drosophila)
Mus musculus
Synonyms:
Protein numb homolog, m-Nb, m-Numb, m-numb
- Drosophila neuroblast 7-3 cell lineage: a model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of ganglion mother cell identity. Karcavich, R., Doe, C.Q. J. Comp. Neurol. (2005)
- Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas. Yoshida, T., Tokunaga, A., Nakao, K., Okano, H. Differentiation (2003)
- Postnatal deletion of numb/numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Kuo, C.T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M., Wang, D., Shen, J., Sestan, N., Garcia-Verdugo, J., Alvarez-Buylla, A., Jan, L.Y., Jan, Y.N. Cell (2006)
- Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Petersen, P.H., Zou, K., Hwang, J.K., Jan, Y.N., Zhong, W. Nature (2002)
- Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Huang, E.J., Li, H., Tang, A.A., Wiggins, A.K., Neve, R.L., Zhong, W., Jan, L.Y., Jan, Y.N. Genes Dev. (2005)
- Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Klezovitch, O., Fernandez, T.E., Tapscott, S.J., Vasioukhin, V. Genes Dev. (2004)
- Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Petersen, P.H., Zou, K., Krauss, S., Zhong, W. Nat. Neurosci. (2004)
- Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification. French, M.B., Koch, U., Shaye, R.E., McGill, M.A., Dho, S.E., Guidos, C.J., McGlade, C.J. J. Immunol. (2002)
- Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Zhong, W., Feder, J.N., Jiang, M.M., Jan, L.Y., Jan, Y.N. Neuron (1996)
- Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Li, H.S., Wang, D., Shen, Q., Schonemann, M.D., Gorski, J.A., Jones, K.R., Temple, S., Jan, L.Y., Jan, Y.N. Neuron (2003)
- Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Shinin, V., Gayraud-Morel, B., Gomès, D., Tajbakhsh, S. Nat. Cell Biol. (2006)
- Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Zhong, W., Jiang, M.M., Weinmaster, G., Jan, L.Y., Jan, Y.N. Development (1997)
- The Notch regulator Numb links the Notch and TCR signaling pathways. Anderson, A.C., Kitchens, E.A., Chan, S.W., St Hill, C., Jan, Y.N., Zhong, W., Robey, E.A. J. Immunol. (2005)
- Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Arimura, N., Ménager, C., Kawano, Y., Yoshimura, T., Kawabata, S., Hattori, A., Fukata, Y., Amano, M., Goshima, Y., Inagaki, M., Morone, N., Usukura, J., Kaibuchi, K. Mol. Cell. Biol. (2005)
- Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. Dho, S.E., French, M.B., Woods, S.A., McGlade, C.J. J. Biol. Chem. (1999)
- The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX. Dho, S.E., Jacob, S., Wolting, C.D., French, M.B., Rohrschneider, L.R., McGlade, C.J. J. Biol. Chem. (1998)
- Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease. Chan, S.L., Pedersen, W.A., Zhu, H., Mattson, M.P. Neuromolecular Med. (2002)
- Multiple roles of mouse Numb in tuning developmental cell fates. Zilian, O., Saner, C., Hagedorn, L., Lee, H.Y., Säuberli, E., Suter, U., Sommer, L., Aguet, M. Curr. Biol. (2001)
- Differential expression of cell fate determinants in neurons and glial cells of adult mouse spinal cord after compression injury. Chen, J., Leong, S.Y., Schachner, M. Eur. J. Neurosci. (2005)
- Differential expression of Pax6 and Ngn2 between pair-generated cortical neurons. Kawaguchi, A., Ogawa, M., Saito, K., Matsuzaki, F., Okano, H., Miyata, T. J. Neurosci. Res. (2004)
- Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate. Braydich-Stolle, L., Nolan, C., Dym, M., Hofmann, M.C. Ann. N. Y. Acad. Sci. (2005)