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Gene Review

Osm  -  oncostatin M

Mus musculus

Synonyms: OSM, OncoM, Oncostatin-M
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Disease relevance of Osm


High impact information on Osm


Chemical compound and disease context of Osm


Biological context of Osm


Anatomical context of Osm


Associations of Osm with chemical compounds


Regulatory relationships of Osm


Other interactions of Osm

  • Differential regulation of macrophage differentiation in response to leukemia inhibitory factor/oncostatin-M/interleukin-6: the effect of enforced expression of the SCL transcription factor [22].
  • OSM was able to fully substitute for LIF; both cytokines promoted the proliferation of migratory PGC (mPGC) and enhanced the viability of postmigratory (colonizing) PGC (cPGC) when cultured on SI/SI4-m220 cells [23].
  • Ciliary neurotrophic factor, but not oncostatin M, had the same effect, although they both bind to the IL-6ST (gp130) receptor [24].
  • Mouse OSM, LIF and CT-1 strongly induced the formation of tartrate resistant acid phosphatase positive (TRAP(+)) multinucleated cells (MNC) in a dose-dependent fashion [17].
  • Combination of IL-4 and OSM synergistically enhanced eotaxin-1 expression in MLF [11].

Analytical, diagnostic and therapeutic context of Osm


  1. Oncostatin M regulates eotaxin expression in fibroblasts and eosinophilic inflammation in C57BL/6 mice. Langdon, C., Kerr, C., Tong, L., Richards, C.D. J. Immunol. (2003) [Pubmed]
  2. Oncostatin-M: a new bone active cytokine that activates osteoblasts and inhibits bone resorption. Jay, P.R., Centrella, M., Lorenzo, J., Bruce, A.G., Horowitz, M.C. Endocrinology (1996) [Pubmed]
  3. Oncostatin M stimulates the detachment of a reservoir of invasive mammary carcinoma cells: role of cyclooxygenase-2. Holzer, R.G., Ryan, R.E., Tommack, M., Schlekeway, E., Jorcyk, C.L. Clin. Exp. Metastasis (2004) [Pubmed]
  4. Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. Modur, V., Feldhaus, M.J., Weyrich, A.S., Jicha, D.L., Prescott, S.M., Zimmerman, G.A., McIntyre, T.M. J. Clin. Invest. (1997) [Pubmed]
  5. Regulation of an extrathymic T-cell development pathway by oncostatin M. Clegg, C.H., Rulffes, J.T., Wallace, P.M., Haugen, H.S. Nature (1996) [Pubmed]
  6. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Broxmeyer, H.E., Bruns, H.A., Zhang, S., Cooper, S., Hangoc, G., McKenzie, A.N., Dent, A.L., Schindler, U., Naeger, L.K., Hoey, T., Kaplan, M.H. Immunity (2002) [Pubmed]
  7. In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region. Mukouyama, Y., Hara, T., Xu, M., Tamura, K., Donovan, P.J., Kim, H., Kogo, H., Tsuji, K., Nakahata, T., Miyajima, A. Immunity (1998) [Pubmed]
  8. Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice. Browning, P.J., Roberts, D.D., Zabrenetzky, V., Bryant, J., Kaplan, M., Washington, R.H., Panet, A., Gallo, R.C., Vogel, T. J. Exp. Med. (1994) [Pubmed]
  9. Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis. Menon, M.P., Karur, V., Bogacheva, O., Bogachev, O., Cuetara, B., Wojchowski, D.M. J. Clin. Invest. (2006) [Pubmed]
  10. Effect of oncostatin-M on proliferation and activity in osteoblastic MC3T3-E1 cells. Shih, C., Yen, C.C. Zhonghua Yi Xue Za Zhi (Taipei) (1999) [Pubmed]
  11. Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression: involvement of STAT6. Fritz, D.K., Kerr, C., Tong, L., Smyth, D., Richards, C.D. J. Immunol. (2006) [Pubmed]
  12. Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand. de Hooge, A.S., van de Loo, F.A., Bennink, M.B., de Jong, D.S., Arntz, O.J., Lubberts, E., Richards, C.D., vandDen Berg, W.B. Am. J. Pathol. (2002) [Pubmed]
  13. Murine oncostatin M stimulates mouse synovial fibroblasts in vitro and induces inflammation and destruction in mouse joints in vivo. Langdon, C., Kerr, C., Hassen, M., Hara, T., Arsenault, A.L., Richards, C.D. Am. J. Pathol. (2000) [Pubmed]
  14. Oncostatin m regulates mesenchymal cell differentiation and enhances hematopoietic supportive activity of bone marrow stromal cell lines. Yanai, N., Obinata, M. In Vitro Cell. Dev. Biol. Anim. (2001) [Pubmed]
  15. Oncostatin M differentially regulates CXC chemokines in mouse cardiac fibroblasts. Lafontant, P.J., Burns, A.R., Donnachie, E., Haudek, S.B., Smith, C.W., Entman, M.L. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  16. Leukemia inhibitory factor induces DNA synthesis in Swiss mouse 3T3 cells independently of cyclin D1 expression through a mechanism involving MEK/ERK1/2 activation. Dekanty, A., Sauane, M., Cadenas, B., Coluccio, F., Barrio, M., Casala, J., Paciencia, M., Rogers, F., Coso, O.A., Piwien-Pilipuk, G., Rudland, P.S., de Asúa, L.J. J. Biol. Chem. (2006) [Pubmed]
  17. Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: synergy with dexamethasone. Richards, C.D., Langdon, C., Deschamps, P., Pennica, D., Shaughnessy, S.G. Cytokine (2000) [Pubmed]
  18. Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice. Fouladi-Nashta, A.A., Jones, C.J., Nijjar, N., Mohamet, L., Smith, A., Chambers, I., Kimber, S.J. Dev. Biol. (2005) [Pubmed]
  19. Thrombocytopoietic properties of oncostatin M. Wallace, P.M., MacMaster, J.F., Rillema, J.R., Peng, J., Burstein, S.A., Shoyab, M. Blood (1995) [Pubmed]
  20. Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Nakamura, K., Nonaka, H., Saito, H., Tanaka, M., Miyajima, A. Hepatology (2004) [Pubmed]
  21. Expression of oncostatin M in hematopoietic organs. Tamura, S., Morikawa, Y., Miyajima, A., Senba, E. Dev. Dyn. (2002) [Pubmed]
  22. Differential regulation of macrophage differentiation in response to leukemia inhibitory factor/oncostatin-M/interleukin-6: the effect of enforced expression of the SCL transcription factor. Tanigawa, T., Nicola, N., McArthur, G.A., Strasser, A., Begley, C.G. Blood (1995) [Pubmed]
  23. Functional requirement of gp130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells. Koshimizu, U., Taga, T., Watanabe, M., Saito, M., Shirayoshi, Y., Kishimoto, T., Nakatsuji, N. Development (1996) [Pubmed]
  24. Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture. Kanatsu-Shinohara, M., Inoue, K., Ogonuki, N., Miki, H., Yoshida, S., Toyokuni, S., Lee, J., Ogura, A., Shinohara, T. Biol. Reprod. (2007) [Pubmed]
  25. Targeted disruption of oncostatin M receptor results in altered hematopoiesis. Tanaka, M., Hirabayashi, Y., Sekiguchi, T., Inoue, T., Katsuki, M., Miyajima, A. Blood (2003) [Pubmed]
  26. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. Kamiya, A., Kinoshita, T., Ito, Y., Matsui, T., Morikawa, Y., Senba, E., Nakashima, K., Taga, T., Yoshida, K., Kishimoto, T., Miyajima, A. EMBO J. (1999) [Pubmed]
  27. Osteoclasts are present in gp130-deficient mice. Kawasaki, K., Gao, Y.H., Yokose, S., Kaji, Y., Nakamura, T., Suda, T., Yoshida, K., Taga, T., Kishimoto, T., Kataoka, H., Yuasa, T., Norimatsu, H., Yamaguchi, A. Endocrinology (1997) [Pubmed]
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