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Gene Review

OSMR  -  oncostatin M receptor

Homo sapiens

Synonyms: IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB, Interleukin-31 receptor subunit beta, ...
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Disease relevance of OSMR


High impact information on OSMR

  • We studied signaling by the OSM receptor in three AIDS-related KS lines and show induction of tyrosine phosphorylation of 145-, 120-, 85-, and 42-kD substrates [7].
  • A second high-affinity receptor for hOSM was recently found to be formed by gp130 and the hOSM receptor beta subunit [8].
  • We can show that the OSMR-mediated signaling is inhibited by SOCS3 to a similar extent as previously described for gp130 [9].
  • However, the inhibition occurs independent of tyrosine motifs within the OSMR [9].
  • This mutant still binds to the receptor subunits gp130 and OSMR [10].

Chemical compound and disease context of OSMR


Biological context of OSMR

  • The 36 residue carboxyl-terminal region containing the distal box 3 sequence motif of OSMR is required for signal transduction by the OSM-specific receptor [11].
  • Finally, we demonstrate that mutation of tyrosine 861 abrogates OSMR-mediated cell proliferation and identify Erk1/2 as mainly responsible for the proliferative effect [12].
  • A recent study reported the involvement of GPL, together with OSMR, in the formation of the receptor complex for IL-31, a novel immune cytokine with a skin tropism [13].
  • These results indicate that OSM is a key mediator for inducing differentiation of OC15-5 cells into hepatocytes and suggest that the OSM/OSM-R system is pivotal in the differentiation of oval cells into hepatocytes, thereby promoting liver regeneration [14].
  • The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells [15].

Anatomical context of OSMR

  • Homodimers of the LIFR or OSMR cytoplasmic regions did not elicit responses in COS-7 cells but did in HepG2 cells and in MCF-7 breast carcinoma cells [1].
  • Chimeric receptors consisting of the extracellular region of the interleukin-5 receptor beta chain and the transmembrane and intracellular part of the OSMR were similarly up-regulated on the plasma membrane when Jak1 was coexpressed [16].
  • Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns [17].

Associations of OSMR with chemical compounds


Other interactions of OSMR

  • We investigated the contributions of LIFR and OSMR to signal transduction in the context of heterodimers with gp130 [1].
  • They both involve the gp130-transducing receptor, which dimerizes with either leukemia inhibitory receptor beta or with OSM receptor beta (OSMRbeta) to generate, respectively, type I and type II OSM receptors [3].
  • This cytokine binds two distinct receptor complexes: type I OSM receptor which is also a functional receptor for leukemia inhibitory factor (LIF), and type II OSM-specific receptor [18].
  • Here, we will discuss underlying mechanisms as well as some structural features with a focus on Jak1 and two of the signal transducing receptor subunits of interleukin (IL)-6 type cytokines, gp130 and OSMR [20].

Analytical, diagnostic and therapeutic context of OSMR


  1. Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130. Hermanns, H.M., Radtke, S., Haan, C., Schmitz-Van de Leur, H., Tavernier, J., Heinrich, P.C., Behrmann, I. J. Immunol. (1999) [Pubmed]
  2. Molecular and functional characterization of a soluble form of oncostatin m/interleukin-31 shared receptor. Diveu, C., Venereau, E., Froger, J., Ravon, E., Grimaud, L., Rousseau, F., Chevalier, S., Gascan, H. J. Biol. Chem. (2006) [Pubmed]
  3. Signaling of type II oncostatin M receptor. Auguste, P., Guillet, C., Fourcin, M., Olivier, C., Veziers, J., Pouplard-Barthelaix, A., Gascan, H. J. Biol. Chem. (1997) [Pubmed]
  4. Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas. Savarese, T.M., Campbell, C.L., McQuain, C., Mitchell, K., Guardiani, R., Quesenberry, P.J., Nelson, B.E. Cytokine (2002) [Pubmed]
  5. Oncostatin M (OSM) Cytostasis of Breast Tumor Cells: Characterization of an OSM Receptor {beta}-Specific Kernel. Underhill-Day, N., Heath, J.K. Cancer Res. (2006) [Pubmed]
  6. Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. Deng, G., Kakar, S., Okudiara, K., Choi, E., Sleisenger, M.H., Kim, Y.S. Clin. Cancer Res. (2009) [Pubmed]
  7. Oncostatin-M stimulates tyrosine protein phosphorylation in parallel with the activation of p42MAPK/ERK-2 in Kaposi's cells. Evidence that this pathway is important in Kaposi cell growth. Amaral, M.C., Miles, S., Kumar, G., Nel, A.E. J. Clin. Invest. (1993) [Pubmed]
  8. Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice. Ichihara, M., Hara, T., Kim, H., Murate, T., Miyajima, A. Blood (1997) [Pubmed]
  9. Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. Stross, C., Radtke, S., Clahsen, T., Gerlach, C., Volkmer-Engert, R., Schaper, F., Heinrich, P.C., Hermanns, H.M. J. Biol. Chem. (2006) [Pubmed]
  10. The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression. Radtke, S., Haan, S., Jörissen, A., Hermanns, H.M., Diefenbach, S., Smyczek, T., Schmitz-Vandeleur, H., Heinrich, P.C., Behrmann, I., Haan, C. J. Biol. Chem. (2005) [Pubmed]
  11. Influence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6. Kuropatwinski, K.K., De Imus, C., Gearing, D., Baumann, H., Mosley, B. J. Biol. Chem. (1997) [Pubmed]
  12. Oncostatin M-induced activation of stress-activated MAP kinases depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases. Böing, I., Stross, C., Radtke, S., Lippok, B.E., Heinrich, P.C., Hermanns, H.M. Cell. Signal. (2006) [Pubmed]
  13. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. Diveu, C., Lak-Hal, A.H., Froger, J., Ravon, E., Grimaud, L., Barbier, F., Hermann, J., Gascan, H., Chevalier, S. Eur. Cytokine Netw. (2004) [Pubmed]
  14. Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes. Okaya, A., Kitanaka, J., Kitanaka, N., Satake, M., Kim, Y., Terada, K., Sugiyama, T., Takemura, M., Fujimoto, J., Terada, N., Miyajima, A., Tsujimura, T. Am. J. Pathol. (2005) [Pubmed]
  15. The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells. Auernhammer, C.J., Dorn, F., Vlotides, G., Hengge, S., Kopp, F.B., Spoettl, G., Cengic, N., Engelhardt, D., Weber, M.M. J. Endocrinol. (2004) [Pubmed]
  16. Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression. Radtke, S., Hermanns, H.M., Haan, C., Schmitz-Van De Leur, H., Gascan, H., Heinrich, P.C., Behrmann, I. J. Biol. Chem. (2002) [Pubmed]
  17. Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns. Bando, T., Morikawa, Y., Komori, T., Senba, E. Neuroscience (2006) [Pubmed]
  18. Regulation of the type II oncostatin M receptor expression in lung-derived epithelial cells. Cichy, J., Rose-John, S., Puré, E. FEBS Lett. (1998) [Pubmed]
  19. Properties of cryopreserved fetal liver stem/progenitor cells that exhibit long-term repopulation of the normal rat liver. Oertel, M., Menthena, A., Chen, Y.Q., Shafritz, D.A. Stem Cells (2006) [Pubmed]
  20. Jaks and cytokine receptors-An intimate relationship. Haan, C., Kreis, S., Margue, C., Behrmann, I. Biochem. Pharmacol. (2006) [Pubmed]
  21. Interleukin-6 and oncostatin M stimulation of proliferation of prostate cancer 22Rv1 cells through the signaling pathways of p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Godoy-Tundidor, S., Cavarretta, I.T., Fuchs, D., Fiechtl, M., Steiner, H., Friedbichler, K., Bartsch, G., Hobisch, A., Culig, Z. Prostate (2005) [Pubmed]
  22. Oncostatin M-specific receptor expression and function in regulating cell proliferation of normal and malignant mammary epithelial cells. Liu, J., Hadjokas, N., Mosley, B., Estrov, Z., Spence, M.J., Vestal, R.E. Cytokine (1998) [Pubmed]
  23. Transcriptional gene expression profile of human esophageal squamous cell carcinoma. Sharma, R., Samantaray, S., Shukla, N.K., Ralhan, R. Genomics (2003) [Pubmed]
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