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Gene Review

Ptpn12  -  protein tyrosine phosphatase, non-receptor...

Mus musculus

Synonyms: MPTP-PEST, P19-PTP, PTP-P19, PTP-PEST, PTPG1, ...
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Disease relevance of Ptpn12

  • We have used lambda phage analysis to elucidate the complete genomic structure of an intracellular member of this family, the murine MPTP-PEST gene [1].

High impact information on Ptpn12

  • Phosphorylation of this site together with the intact phosphotyrosine-binding domain was essential for ShcA binding to the protein-tyrosine phosphatase PTP-PEST [2].
  • Overexpression of a PTP-PEST binding-defective mutant of p52(Shc) (S29A) enhanced insulin-induced ERK activation in insulin receptor-overexpressing HIRc-B cells [2].
  • TPA-induced ShcA phosphorylation at this site (and hence, its association with PTP-PEST) was inhibited by a protein kinase C-specific inhibitor and was induced by overexpression of constitutively active mutants of protein kinase Calpha, -epsilon, and -delta isoforms [2].
  • The cytoplasmic protein tyrosine phosphatase (PTP)-proline-glutamic acid-serine-threonine amino acid sequences (PEST) was also found to be associated with gelsolin in osteoclast podosomes and with stimulation of alpha(v)beta(3)-regulated phosphorylation of PTP-PEST [3].
  • Our studies revealed that Csk was associated with PTP-PEST in a variety of cell types, including non-hemopoietic cells [4].

Biological context of Ptpn12


Anatomical context of Ptpn12


Associations of Ptpn12 with chemical compounds


Other interactions of Ptpn12

  • Through its specific association to p130cas and further dephosphorylation, PTP-PEST plays a critical role in cell-matrix interactions, which are essential during embryogenesis [5].
  • Insulin also induced ShcA/PTP-PEST association, although to a lesser extent than TPA [2].

Analytical, diagnostic and therapeutic context of Ptpn12


  1. Structure of the murine MPTP-PEST gene: genomic organization and chromosomal mapping. Charest, A., Wagner, J., Muise, E.S., Heng, H.H., Tremblay, M.L. Genomics (1995) [Pubmed]
  2. Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling. Faisal, A., el-Shemerly, M., Hess, D., Nagamine, Y. J. Biol. Chem. (2002) [Pubmed]
  3. Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. Chellaiah, M.A., Biswas, R.S., Yuen, D., Alvarez, U.M., Hruska, K.A. J. Biol. Chem. (2001) [Pubmed]
  4. Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells. Davidson, D., Cloutier, J.F., Gregorieff, A., Veillette, A. J. Biol. Chem. (1997) [Pubmed]
  5. Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Sirois, J., C??t??, J.F., Charest, A., Uetani, N., Bourdeau, A., Duncan, S.A., Daniels, E., Tremblay, M.L. Mech. Dev. (2006) [Pubmed]
  6. Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase. Charest, A., Wagner, J., Shen, S.H., Tremblay, M.L. Biochem. J. (1995) [Pubmed]
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