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Gene Review

Ncor2  -  nuclear receptor co-repressor 2

Mus musculus

Synonyms: N-CoR, N-CoR2, Nuclear receptor corepressor 2, SMRT, SMRTe, ...
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Disease relevance of Ncor2

  • Here, we show that IKK is activated in colorectal tumors concomitant with the presence of phosphorylated SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor that is aberrantly localized in the cytoplasm [1].
  • The AR mutation T877A (Thr877-->Ala), which is frequently found in prostate cancer and affects the ligand-induced conformational change of the AR, considerably reduced the repressive action of N-CoR [2].

High impact information on Ncor2

  • Here, we report that transcriptional activation mediated by liganded nuclear receptors unexpectedly requires the actions of two highly related F box/WD-40-containing factors, TBL1 and TBLR1, initially identified as components of an N-CoR corepressor complex [3].
  • N-CoR controls differentiation of neural stem cells into astrocytes [4].
  • Recruitment of protein phosphatase-1 to a specific binding site on N-CoR exerts a reciprocal effect on the cellular localization of N-CoR [4].
  • Association of PPRE-bound PV with corepressors [e.g., nuclear receptor corepressor (NCoR)] that led to transcriptional repression was independent of T3 and troglitazone [5].
  • Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development [6].

Biological context of Ncor2


Anatomical context of Ncor2


Associations of Ncor2 with chemical compounds

  • Such corepressors include the nuclear receptor corepressor (NCoR) and the silencing mediator of retinoid and thyroid hormone receptors (SMRT) [9].
  • The nuclear receptor corepressor (NCoR) and the related factor known as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) are essential components of multiprotein complexes that mediate active repression by unliganded nuclear receptors [14].
  • Glutathione S-transferase pulldown assays confirmed a direct interaction between HNF4alpha1 and receptor interaction domain 2 of SMRT [15].
  • This isoleucine is also conserved in N2 but not in the corresponding S2 domain in SMRT [16].
  • Small amounts of co-transfected N-CoR repressed CPA (cyproterone acetate)- and mifepristone (RU486)-mediated AR activity, but did not affect agonist (R1881)-induced AR activity [2].
  • Stimulation of estradiol-induced ERalpha activity by SMRT overexpression occurred in HeLa and MCF-7 cells, but not HepG2 cells, indicating that these positive effects are cell type specific [17].

Regulatory relationships of Ncor2


Analytical, diagnostic and therapeutic context of Ncor2

  • The relative expression levels of both fluorescent proteins are estimated, and YFP-NCoR subnuclear organization is quantified based on the mean focal body size and relative intensity [19].
  • Chromatin immunoprecipitation assay further demonstrated that, despite the presence of ligands, NCoR was recruited to PPRE-bound PV on a PPARgamma-target gene, the lipoprotein lipase, in vivo, suggesting the dominant action of PV on PPARgamma-mediated transcriptional activity [5].


  1. Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer. Fern??ndez-Majada, V., Aguilera, C., Villanueva, A., Vilardell, F., Robert-Moreno, A., Ayt??s, A., Real, F.X., Capella, G., Mayo, M.W., Espinosa, L., Bigas, A. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  2. Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR). Berrevoets, C.A., Umar, A., Trapman, J., Brinkmann, A.O. Biochem. J. (2004) [Pubmed]
  3. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Perissi, V., Aggarwal, A., Glass, C.K., Rose, D.W., Rosenfeld, M.G. Cell (2004) [Pubmed]
  4. N-CoR controls differentiation of neural stem cells into astrocytes. Hermanson, O., Jepsen, K., Rosenfeld, M.G. Nature (2002) [Pubmed]
  5. Thyroid hormone receptor beta mutants: Dominant negative regulators of peroxisome proliferator-activated receptor gamma action. Araki, O., Ying, H., Furuya, F., Zhu, X., Cheng, S.Y. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development. Yan, M., Burel, S.A., Peterson, L.F., Kanbe, E., Iwasaki, H., Boyapati, A., Hines, R., Akashi, K., Zhang, D.E. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Jepsen, K., Hermanson, O., Onami, T.M., Gleiberman, A.S., Lunyak, V., McEvilly, R.J., Kurokawa, R., Kumar, V., Liu, F., Seto, E., Hedrick, S.M., Mandel, G., Glass, C.K., Rose, D.W., Rosenfeld, M.G. Cell (2000) [Pubmed]
  8. SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. Park, E.J., Schroen, D.J., Yang, M., Li, H., Li, L., Chen, J.D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. Yu, C., Markan, K., Temple, K.A., Deplewski, D., Brady, M.J., Cohen, R.N. J. Biol. Chem. (2005) [Pubmed]
  10. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Lavinsky, R.M., Jepsen, K., Heinzel, T., Torchia, J., Mullen, T.M., Schiff, R., Del-Rio, A.L., Ricote, M., Ngo, S., Gemsch, J., Hilsenbeck, S.G., Osborne, C.K., Glass, C.K., Rosenfeld, M.G., Rose, D.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors. Wang, Q., Blackford, J.A., Song, L.N., Huang, Y., Cho, S., Simons, S.S. Mol. Endocrinol. (2004) [Pubmed]
  12. Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Wagner, B.L., Valledor, A.F., Shao, G., Daige, C.L., Bischoff, E.D., Petrowski, M., Jepsen, K., Baek, S.H., Heyman, R.A., Rosenfeld, M.G., Schulman, I.G., Glass, C.K. Mol. Cell. Biol. (2003) [Pubmed]
  13. Nuclear corepressor and silencing mediator of retinoic and thyroid hormone receptors corepressor expression is incompatible with T(3)-dependent TRH regulation. Becker, N., Seugnet, I., Guissouma, H., Dupre, S.M., Demeneix, B.A. Endocrinology (2001) [Pubmed]
  14. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Ogawa, S., Lozach, J., Jepsen, K., Sawka-Verhelle, D., Perissi, V., Sasik, R., Rose, D.W., Johnson, R.S., Rosenfeld, M.G., Glass, C.K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  15. Competitive cofactor recruitment by orphan receptor hepatocyte nuclear factor 4alpha1: modulation by the F domain. Ruse, M.D., Privalsky, M.L., Sladek, F.M. Mol. Cell. Biol. (2002) [Pubmed]
  16. Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor. Makowski, A., Brzostek, S., Cohen, R.N., Hollenberg, A.N. Mol. Endocrinol. (2003) [Pubmed]
  17. The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity. Peterson, T.J., Karmakar, S., Pace, M.C., Gao, T., Smith, C.L. Mol. Cell. Biol. (2007) [Pubmed]
  18. AP-1 transrepressing retinoic acid does not deplete coactivators or AP-1 monomers but may target specific Jun or Fos containing dimers. Suzukawa, K., Colburn, N.H. Oncogene (2002) [Pubmed]
  19. Computer-assisted image analysis protocol that quantitatively measures subnuclear protein organization in cell populations. Voss, T.C., Demarco, I.A., Booker, C.F., Day, R.N. BioTechniques (2004) [Pubmed]
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