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Gene Review

Scg2  -  secretogranin II

Mus musculus

Synonyms: Chgc, Chromogranin-C, Scg-2, Secretogranin II, Secretogranin-2, ...
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Disease relevance of Scg2


Psychiatry related information on Scg2


High impact information on Scg2

  • Chromogranin B and secretogranin II immunoblots showed no change after PC1 reduction [4].
  • These peptides represent fragments of 16 known secretory pathway proteins, including proenkephalin, proopiomelanocortin, protachykinins A and B, chromogranin A and B, and secretogranin II [5].
  • However, GR mutant mice lack the adrenaline-synthesizing enzyme PNMT and secretogranin II [6].
  • The 5' deletions localized neuroendocrine cell type-specific expression to the proximal mouse secretogranin II promoter: such expression was abolished after deletion past the cAMP response element (CRE; [-67 bp]TGACGTCA[-60 bp]), and transfer of the CRE to a neutral promoter conferred 3.4- to 5.3-fold neuroendocrine selectivity [7].
  • Characterization of the endopeptidase PC2 activity towards secretogranin II in stably transfected PC12 cells [8].

Chemical compound and disease context of Scg2

  • SgII promoter activities in the neuroblastoma cell lines correlated not only with the levels of SgII but also the levels of the cyclic AMP response element-binding protein CREB which were highest in BE(2)-M17 cells and lowest in SH-SY5Y cells [2].

Biological context of Scg2


Anatomical context of Scg2

  • Two primary Ewing's sarcomas, one primary PNET (an Askin tumor), and one PNET cell line (TC32) were found to strongly express the SgII gene, as shown by the presence of specific mRNA [1].
  • Our results demonstrate that SgII is proteolytically processed by PC2 in the immature secretory granule into several lower-molecular-mass proteins, the major ones being an 18 kDa sulphated fragment and a 28 kDa fragment [8].
  • Peptides found to increase corresponded to fragments of proenkephalin, prothyrotropin-releasing hormone, provasopressin, proSAAS, secretogranin II, chromogranin B, and peptidyl-glycine-alpha-amidating mono-oxygenase in the hypothalamus [11].
  • In contrast, in basomedial and central nuclei of amygdala, increased secretogranin II mRNA was found in self-administering mice [12].
  • In the core of the nucleus accumbens and piriform cortex there was increased, and in medial amygdala decreased secretogranin II mRNA in yoked controls compared with saline controls [12].

Associations of Scg2 with chemical compounds

  • In pulse-chase experiments, significant intracellular storage of secretogranin II and chromogranin B was observed and secretion of retained secretogranin II was stimulated with the calcium ionophore A23187 [13].
  • As differences in c-fos and secretogranin II mRNA between active mice and yoked controls were robust, measuring these mRNAs may identify neurons selectively involved in acquisition of cocaine-taking behaviour [12].
  • Inhibition of de novo protein synthesis by cycloheximide did not affect the Sg-II induction [14].
  • The increase in Sg-II mRNA expression was induced depending upon the extracellular Ca2+ and inhibited by nicardipine, indicating a requirement of Ca2+ influx through VDCCs for the Sg-II as well as BDNF gene induction [14].
  • Deprivation and subsequent induction of membrane depolarization by lowering and reelevating the extracellular concentration of potassium chloride (KCl), respectively, led to an decrease and then an increase in the Sg-II, BDNF and c-fos mRNA expression [14].

Other interactions of Scg2


Analytical, diagnostic and therapeutic context of Scg2


  1. Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors. Pagani, A., Fischer-Colbrie, R., Sanfilippo, B., Winkler, H., Cerrato, M., Bussolati, G. Diagn. Mol. Pathol. (1992) [Pubmed]
  2. Isolation and characterization of the human secretogranin II gene promoter. Scammell, J.G., Reddy, S., Valentine, D.L., Coker, T.N., Nikolopoulos, S.N., Ross, R.A. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  3. Peptidomics of Cpe fat/fat mouse hypothalamus: effect of food deprivation and exercise on peptide levels. Che, F.Y., Yuan, Q., Kalinina, E., Fricker, L.D. J. Biol. Chem. (2005) [Pubmed]
  4. Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway. Eskeland, N.L., Zhou, A., Dinh, T.Q., Wu, H., Parmer, R.J., Mains, R.E., O'Connor, D.T. J. Clin. Invest. (1996) [Pubmed]
  5. Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice. Che, F.Y., Yan, L., Li, H., Mzhavia, N., Devi, L.A., Fricker, L.D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Finotto, S., Krieglstein, K., Schober, A., Deimling, F., Lindner, K., Brühl, B., Beier, K., Metz, J., Garcia-Arraras, J.E., Roig-Lopez, J.L., Monaghan, P., Schmid, W., Cole, T.J., Kellendonk, C., Tronche, F., Schütz, G., Unsicker, K. Development (1999) [Pubmed]
  7. Neuroendocrine cell type-specific and inducible expression of the secretogranin II gene: crucial role of cyclic adenosine monophosphate and serum response elements. Mahata, S.K., Mahata, M., Livsey, C.V., Gerdes, H.H., Huttner, W.B., O'Connor, D.T. Endocrinology (1999) [Pubmed]
  8. Characterization of the endopeptidase PC2 activity towards secretogranin II in stably transfected PC12 cells. Dittié, A.S., Tooze, S.A. Biochem. J. (1995) [Pubmed]
  9. The organisation of the mouse secretogranin II gene. Schimmel, A., Bräunling, O., Rüther, U., Huttner, W.B., Gerdes, H.H. FEBS Lett. (1992) [Pubmed]
  10. Differential expression and subcellular localization of secretogranin II and synaptophysin during early development of mouse hypothalamic neurons in culture. Tixier-Vidal, A., Barret, A., Faivre-Bauman, A., Huttner, W., Wiedenmann, B. Neuroscience (1992) [Pubmed]
  11. Quantitative peptidomics in mice: effect of cocaine treatment. Che, F.Y., Vathy, I., Fricker, L.D. J. Mol. Neurosci. (2006) [Pubmed]
  12. Expression of c-fos, NGFI-A and secretogranin II mRNA in brain regions during initiation of cocaine self-administration in mice. Kuzmin, A., Johansson, B. Eur. J. Neurosci. (1999) [Pubmed]
  13. Expression of regulated secretory proteins is sufficient to generate granule-like structures in constitutively secreting cells. Beuret, N., Stettler, H., Renold, A., Rutishauser, J., Spiess, M. J. Biol. Chem. (2004) [Pubmed]
  14. Coactivation of secretogranin-II and BDNF genes mediated by calcium signals in mouse cerebellar granule cells. Fujita, Y., Katagi, J., Tabuchi, A., Tsuchiya, T., Tsuda, M. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  15. Immunolocalisation of chromogranin B, secretogranin II, calcitonin gene-related peptide and substance P at developing and adult neuromuscular synapses. Andreose, J.S., Sala, C., Fumagalli, G. Neurosci. Lett. (1994) [Pubmed]
  16. Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells. Dandoy-Dron, F., Griffond, B., Mishal, Z., Tovey, M.G., Dron, M. Eur. J. Neurosci. (2003) [Pubmed]
  17. Subcellular localization of secretogranin II and synaptophysin by immunoelectron microscopy in differentiated hypothalamic neurons in culture. Kagotani, Y., Picart, R., Barret, A., Wiedenmann, B., Huttner, W.B., Tixier-Vidal, A. J. Histochem. Cytochem. (1991) [Pubmed]
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