Gene Review:
Six5 - sine oculis-related homeobox 5
Mus musculus
Synonyms:
DM locus-associated homeodomain protein homolog, Dmahp, Homeobox protein SIX5, MDMAHP, Sine oculis homeobox homolog 5, ...
- Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Sarkar, P.S., Appukuttan, B., Han, J., Ito, Y., Ai, C., Tsai, W., Chai, Y., Stout, J.T., Reddy, S. Nat. Genet. (2000)
- Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene. Wakimoto, H., Maguire, C.T., Sherwood, M.C., Vargas, M.M., Sarkar, P.S., Han, J., Reddy, S., Berul, C.I. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. (2002)
- Six5 is required for spermatogenic cell survival and spermiogenesis. Sarkar, P.S., Paul, S., Han, J., Reddy, S. Hum. Mol. Genet. (2004)
- Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements. Murakami, Y., Ohto, H., Ikeda, U., Shimada, K., Momoi, T., Kawakami, K. Hum. Mol. Genet. (1998)
- Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy. Klesert, T.R., Cho, D.H., Clark, J.I., Maylie, J., Adelman, J., Snider, L., Yuen, E.C., Soriano, P., Tapscott, S.J. Nat. Genet. (2000)
- Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Grifone, R., Demignon, J., Houbron, C., Souil, E., Niro, C., Seller, M.J., Hamard, G., Maire, P. Development (2005)
- Skeletal muscle Na currents in mice heterozygous for Six5 deficiency. Mistry, D.J., Moorman, J.R., Reddy, S., Mounsey, J.P. Physiol. Genomics (2001)
- Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1. Sato, S., Nakamura, M., Cho, D.H., Tapscott, S.J., Ozaki, H., Kawakami, K. Hum. Mol. Genet. (2002)
- A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat. Boucher, C.A., King, S.K., Carey, N., Krahe, R., Winchester, C.L., Rahman, S., Creavin, T., Meghji, P., Bailey, M.E., Chartier, F.L. Hum. Mol. Genet. (1995)