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Slc8a1  -  solute carrier family 8 (sodium/calcium...

Mus musculus

Synonyms: AI852629, AV344025, D930008O12Rik, Na(+)/Ca(2+)-exchange protein 1, Ncx, ...
 
 
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Disease relevance of Slc8a1

 

High impact information on Slc8a1

 

Biological context of Slc8a1

 

Anatomical context of Slc8a1

  • Ultrastructural analysis revealed gross anomalies in the Ncx1-null contractile apparatus, but physiologic analysis showed normal field-stimulated Ca(2+) transients, suggesting that Ncx-1 function may not be critical for Ca(2+) extrusion from the cytosol as previously thought [4].
  • Ultrastructual analysis demonstrated that Ncx1-deficient mice showed severe disorganization of myofibrils, a lack of Z-lines and swelling of mitochondria in cardiomyocytes [5].
  • 5. Since its expression is restricted to tissues derived from neural crest cells, Ncx may play a role in differentiation and proliferation of neural crest lineage cells [7].
 

Associations of Slc8a1 with chemical compounds

  • There was no response to histamine and serotonin by any part of the bowel, and the response to BaCl2 was the same for both Ncx-/- mice and controls [6].
 

Analytical, diagnostic and therapeutic context of Slc8a1

References

  1. A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient mice. Hatano, M., Aoki, T., Dezawa, M., Yusa, S., Iitsuka, Y., Koseki, H., Taniguchi, M., Tokuhisa, T. J. Clin. Invest. (1997) [Pubmed]
  2. Oncogene amplification in the proximal part of chromosome 6 in rat endometrial adenocarcinoma as revealed by combined BAC/PAC FISH, chromosome painting, zoo-FISH, and allelotyping. Adamovic, T., Trossö, F., Roshani, L., Andersson, L., Petersen, G., Rajaei, S., Helou, K., Levan, G. Genes Chromosomes Cancer (2005) [Pubmed]
  3. Vesicourethral sphincter dysfunction in ncx deficient mice with an increased neuronal cell number in vesical ganglia. Jusuf, A.A., Kojima, S., Matsuo, M., Tokuhisa, T., Hatano, M. J. Urol. (2001) [Pubmed]
  4. Role of sodium-calcium exchanger (Ncx1) in embryonic heart development: a transgenic rescue? Conway, S.J., Kruzynska-Frejtag, A., Wang, J., Rogers, R., Kneer, P.L., Chen, H., Creazzo, T., Menick, D.R., Koushik, S.V. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  5. Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes. Wakimoto, K., Fujimura, H., Iwamoto, T., Oka, T., Kobayashi, K., Kita, S., Kudoh, S., Kuro-o, M., Nabeshima, Y., Shigekawa, M., Imai, Y., Komuro, I. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2003) [Pubmed]
  6. Acetylcholine-related bowel dysmotility in homozygous mutant NCX/HOX11L.1-deficient (NCX-/-) mice-evidence that acetylcholine is implicated in causing intestinal neuronal dysplasia. Yanai, T., Kobayashi, H., Yamataka, A., Lane, G.J., Miyano, T., Hayakawa, T., Satoh, K., Kase, Y., Hatano, M. J. Pediatr. Surg. (2004) [Pubmed]
  7. Ncx, a Hox11 related gene, is expressed in a variety of tissues derived from neural crest cells. Hatano, M., Iitsuka, Y., Yamamoto, H., Dezawa, M., Yusa, S., Kohno, Y., Tokuhisa, T. Anat. Embryol. (1997) [Pubmed]
  8. Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat. Wakimoto, K., Kobayashi, K., Kuro-O, M., Yao, A., Iwamoto, T., Yanaka, N., Kita, S., Nishida, A., Azuma, S., Toyoda, Y., Omori, K., Imahie, H., Oka, T., Kudoh, S., Kohmoto, O., Yazaki, Y., Shigekawa, M., Imai, Y., Nabeshima, Y., Komuro, I. J. Biol. Chem. (2000) [Pubmed]
 
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