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Gene Review

Snapin  -  SNAP-associated protein

Mus musculus

Synonyms: 25kDa, AA407989, AV026596, BLOC-1 subunit 7, Biogenesis of lysosome-related organelles complex 1 subunit 7, ...
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Disease relevance of Snapap


High impact information on Snapap


Biological context of Snapap


Anatomical context of Snapap


Other interactions of Snapap

  • We found that the association of synaptotagmin-1 with SNAP-25 in brain homogenates of snapin mutant mice is impaired [4].
  • Interaction between Snapin and G-CSF receptor [8].
  • Exo70 competes with SNAP23 for Snapin binding, suggesting that Snapin does not provide a direct link between the exocyst and the SNARE complex but, rather, mediates cross-talk between the two complexes by sequential interactions [9].

Analytical, diagnostic and therapeutic context of Snapap

  • Here, the interaction of GCSF-R and Snapin was found by yeast two-hybrid experiment, and the interaction of the two proteins was further confirmed by GST pull-down experiment, mammalian two-hybrid experiment and co-immunoprecipitation study [8].


  1. Molecular characterization of MPT83: a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70. Hewinson, R.G., Michell, S.L., Russell, W.P., McAdam, R.A., Jacobs, W.R. Scand. J. Immunol. (1996) [Pubmed]
  2. Snapin: a SNARE-associated protein implicated in synaptic transmission. Ilardi, J.M., Mochida, S., Sheng, Z.H. Nat. Neurosci. (1999) [Pubmed]
  3. Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex. Chheda, M.G., Ashery, U., Thakur, P., Rettig, J., Sheng, Z.H. Nat. Cell Biol. (2001) [Pubmed]
  4. The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. Tian, J.H., Wu, Z.X., Unzicker, M., Lu, L., Cai, Q., Li, C., Schirra, C., Matti, U., Stevens, D., Deng, C., Rettig, J., Sheng, Z.H. J. Neurosci. (2005) [Pubmed]
  5. The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Fukui, K., Yang, Q., Cao, Y., Takahashi, N., Hatakeyama, H., Wang, H., Wada, J., Zhang, Y., Marselli, L., Nammo, T., Yoneda, K., Onishi, M., Higashiyama, S., Matsuzawa, Y., Gonzalez, F.J., Weir, G.C., Kasai, H., Shimomura, I., Miyagawa, J., Wollheim, C.B., Yamagata, K. Cell metabolism. (2005) [Pubmed]
  6. Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. Buxton, P., Zhang, X.M., Walsh, B., Sriratana, A., Schenberg, I., Manickam, E., Rowe, T. Biochem. J. (2003) [Pubmed]
  7. Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin. Talbot, K., Cho, D.S., Ong, W.Y., Benson, M.A., Han, L.Y., Kazi, H.A., Kamins, J., Hahn, C.G., Blake, D.J., Arnold, S.E. Hum. Mol. Genet. (2006) [Pubmed]
  8. Interaction between Snapin and G-CSF receptor. Yuan, X., Shan, Y., Zhao, Z., Chen, J., Cong, Y. Cytokine (2006) [Pubmed]
  9. Snapin interacts with the Exo70 subunit of the exocyst and modulates GLUT4 trafficking. Bao, Y., Lopez, J.A., James, D.E., Hunziker, W. J. Biol. Chem. (2008) [Pubmed]
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