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Gene Review

Sncg  -  synuclein, gamma

Mus musculus

Synonyms: C79089, Gamma-synuclein, Persyn, persyn
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Disease relevance of Sncg


Psychiatry related information on Sncg


High impact information on Sncg


Biological context of Sncg


Anatomical context of Sncg

  • However, neither beta- nor gamma-synuclein has been detected in Lewy bodies, and thus it is unclear whether these isoforms contribute to neurological pathology [7].
  • We studied the effect of inactivation of gamma-synuclein gene on mouse midbrain dopaminergic neurones [1].
  • Alpha-synucleins and beta-synucleins are present predominantly in the inner plexiform layer, whereas gamma-synuclein is in the nerve fiber layer [2].
  • Under stress conditions a translocation of gamma-synuclein from the perinuclear area to the nucleus occurs exhibiting nucleocytoplasmic shuttling. gamma-Synuclein overexpression reduces neurite outgrowth in a greater extent then alpha-synuclein overexpression [6].

Other interactions of Sncg

  • Given that UCH-L1 deficiency results in axonal degeneration and spheroid formation, our findings suggest that beta- and gamma-synuclein participate in the pathogenesis of axonal swelling in gad mice [7].

Analytical, diagnostic and therapeutic context of Sncg

  • In this paper we present data on the localization and properties of gamma-synuclein in several neuronal and nonneuronal cell cultures [6].


  1. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. Robertson, D.C., Schmidt, O., Ninkina, N., Jones, P.A., Sharkey, J., Buchman, V.L. J. Neurochem. (2004) [Pubmed]
  2. Synucleins in ocular tissues. Surguchov, A., McMahan, B., Masliah, E., Surgucheva, I. J. Neurosci. Res. (2001) [Pubmed]
  3. Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene. Ninkina, N., Papachroni, K., Robertson, D.C., Schmidt, O., Delaney, L., O'Neill, F., Court, F., Rosenthal, A., Fleetwood-Walker, S.M., Davies, A.M., Buchman, V.L. Mol. Cell. Biol. (2003) [Pubmed]
  4. Genomic structure and chromosomal localization of the mouse persyn gene. Alimova-Kost, M.V., Ninkina, N.N., Imreh, S., Gnuchev, N.V., Adu, J., Davies, A.M., Buchman, V.L. Genomics (1999) [Pubmed]
  5. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. Specht, C.G., Schoepfer, R. BMC neuroscience [electronic resource]. (2001) [Pubmed]
  6. gamma-synuclein has a dynamic intracellular localization. Surgucheva, I., McMahon, B., Surguchov, A. Cell Motil. Cytoskeleton (2006) [Pubmed]
  7. Accumulation of beta- and gamma-synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse. Wang, Y.L., Takeda, A., Osaka, H., Hara, Y., Furuta, A., Setsuie, R., Sun, Y.J., Kwon, J., Sato, Y., Sakurai, M., Noda, M., Yoshikawa, Y., Wada, K. Brain Res. (2004) [Pubmed]
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