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Gene Review

MPEG1  -  macrophage expressed 1

Homo sapiens

Synonyms: MPG1, MPS1, Macrophage gene 1 protein, Macrophage-expressed gene 1 protein, Mpg-1
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Disease relevance of MPEG1

  • In addition, MPEG-TNF-alpha drastically inhibited the metastatic colony formation of B16-BL6 melanoma [1].
  • THOPP-MPEG was injected intraperitoneally (0.5 micrograms/g body weight) into the mice 6-8 days after tumor transplantation [2].
  • The purpose of this study was to evaluate the recently developed photosensitizing drug THOPP-MPEG for its efficacy as photosensitizer for LIFD and PDT of renal cell carcinoma [2].
  • No THOPP-MPEG phototoxicity in normal surrounding tissue at a dose of up to 100 mg/kg body weight was seen [2].

High impact information on MPEG1

  • Aqueous solutions of 1 were optically clear, but NMR signals were seen only from the MPEG portion and none from the tetrapyrrole, consistent with dissolved assemblies containing aggregated bilirubin cores within mobile polyether chains [3].
  • B exploiting these orthogonal protecting groups and a novel phenolic ester linker, a series of oligosaccharide of biological importance, Le(x), H-type 2, and Le(y), were synthesized on the polytheylene glycol resin MPEG (Mw 5000) [4].
  • Thus, folate-mediated nanospheres composed of MPEG and PCL are potentially new drug carriers for tumor cell-selective targeting treatments [5].
  • Biodegradable methoxy poly(ethylene glycol)/poly(-caprolactone) (MPEG/PCL) amphiphilic block copolymer nanospheres coupled to folic acid have been designed to target a folate-binding protein that is overexpressed on the surface of many tumoral cells [5].
  • Folate-mediated MPEG/PCL nanospheres were compared with hydroxyl- and amino-terminated nanospheres in terms of their size, surface characteristics, and drug-loading efficiency [5].

Biological context of MPEG1

  • The procedure involves MPEG activation by p-nitrophenylchloroformate for the amino acid or peptide coupling that is in turn activated for the protein binding [6].
  • Advances in data compression technology, including JPEG and MPEG techniques, will significantly affect digital archival and transmission of echocardiograms, which also have clinical implications, particularly in the expanding use of telemedicine [7].

Anatomical context of MPEG1

  • We have demonstrated the specificity of this IACP method by showing that MPEG-modified anti-human red blood cell antibody increases the partition of human erythrocytes from the interface to the PEG-rich top phase (up to 100%) but not the partitioning of either neutrophils or HL60 cells [8].

Associations of MPEG1 with chemical compounds

  • For this purpose, hydroxy groups terminated on the MPEG/PCL copolymer were converted into primary amino groups, which were used to conjugate with the carboxylic group of folic acid [5].
  • Reduction of the amount of data can be accomplished with image compression, in particular MPEG-1 (Moving Pictures Expert Group), which is designed for dynamic image sequences [9].
  • Results demonstrate that vesicles containing PE-DTTA and without PE-MPEG can be lyophilized and rehydrated with no change in average size or size distribution so long as the external sucrose concentration is greater than approx. 250 mM [10].
  • The effect of different 2-acrylamido-2-methylpropanesulfonic acid sodium salt (AMPS)-methoxypolyethyleneglycol methacrylate (MPEG) comb-like copolymers on the adsorption behavior, electrokinetic and rheological properties of alumina suspensions has been investigated [11].
  • It was found that polymerization of 2-hydroxyethyl methacrylate in the presence of poly (ethylene glycol) methyl ether (MPEG) enabled the more porous and swellable matrics to be obtained, the higher the molecular weight of MPEG [12].

Regulatory relationships of MPEG1


Other interactions of MPEG1

  • In the first telesurgery procedure we used M-JPEG compression and transmitted the data using fibre optic connections (ATM OC-3) at a bandwidth of 155 Mbit/s. In the second telesurgery procedure video images were transmitted over four E1 digital lines, amounting to about 8 Mbit/s of bandwidth, with better compression standards, such as MPEG1 and 2 [14].

Analytical, diagnostic and therapeutic context of MPEG1

  • The reduced rate of systemic reaction and rapid rise in IgG antibody that was noted with MPEG conjugates make them worth further exploration as agents for immunotherapy [15].
  • The ability to correctly identify regional wall motion abnormalities did not decrease until compression ratios of 1:200 or higher were used.Digital echocardiography loops, MPEG-1-compressed at an effective ratio of 200:1, demonstrate no degradation in endocardial visualization quality or diagnostic content [9].
  • Two melting points from MPEG block and poly(L-alanine), respectively, could be observed in differential scanning calorimetry curves of the co-polymers, suggesting that a micro-domain phase separation appeared in their bulky states [16].
  • PRIMARY OBJECTIVES: The objective of this study was to compare the clinical usefulness, in the field of epileptology, of digital moving images and electroencephalogram (EEG) waveforms by Motion Pictures Expert Group compression algorithms (MPEG-1 and MPEG-2) to that of conventional analogue recording [17].


  1. In vivo anti-tumor efficacy of polyethylene glycol-modified tumor necrosis factor-alpha against tumor necrosis factor-resistant tumors. Tsutsumi, Y., Tsunoda, S., Kaneda, Y., Kamada, H., Kihira, T., Nakagawa, S., Yamamoto, Y., Horisawa, Y., Mayumi, T. Jpn. J. Cancer Res. (1996) [Pubmed]
  2. Laser-induced fluorescence diagnosis and photodynamic therapy of human renal cell carcinoma. Pomer, S., Grashev, G., Sinn, H., Kälble, T., Staehler, G. Urologia internationalis. (1995) [Pubmed]
  3. pKa and aggregation of bilirubin: titrimetric and ultracentrifugation studies on water-soluble pegylated conjugates of bilirubin and fatty acids. Boiadjiev, S.E., Watters, K., Wolf, S., Lai, B.N., Welch, W.H., McDonagh, A.F., Lightner, D.A. Biochemistry (2004) [Pubmed]
  4. A highly efficient synthetic strategy for polymeric support synthesis of Le(x), Le(y), and H-type 2 oligosaccharides. Zhu, T., Boons, G.J. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
  5. Preparation and characterization of methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs. Park, E.K., Lee, S.B., Lee, Y.M. Biomaterials (2005) [Pubmed]
  6. Enzyme modification by MPEG with an amino acid or peptide as spacer arms. Sartore, L., Caliceti, P., Schiavon, O., Veronese, F.M. Appl. Biochem. Biotechnol. (1991) [Pubmed]
  7. Update on new technologies in pediatric echocardiography. Bezold, L.I., Lewin, M.B., Vick, G.W., Pignatelli, R. Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. (1997) [Pubmed]
  8. Separation of cell mixtures by immunoaffinity cell partitioning: strategies for low abundance cells. Delgado, C., Anderson, R.J., Francis, G.E., Fisher, D. Anal. Biochem. (1991) [Pubmed]
  9. Effects of MPEG compression on the quality and diagnostic accuracy of digital echocardiography studies. Spencer, K., Solomon, L., Mor-Avi, V., Dean, K., Weinert, L., Gulati, M., Herle, A., Spiegel, A., Balasia, B., Pionke, T., Sieb, L., Lang, R.M. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. (2000) [Pubmed]
  10. Lyophilization and rehydration of polymer-coated lipid vesicles containing a lipophilic chelator in the presence of sucrose: labeling with 99mTc and biodistribution studies. Szucs, M., Tilcock, C. Nucl. Med. Biol. (1995) [Pubmed]
  11. Alumina interaction with AMPS-MPEG random copolymers III. Effect of PEG segment length on adsorption, electrokinetic and rheological behavior. Bouhamed, H., Magnin, A., Boufi, S. Journal of colloid and interface science. (2006) [Pubmed]
  12. Controlled release of proteins and peptides from hydrogels synthesized by gamma ray-induced polymerization. Caliceti, P., Veronese, F., Schiavon, O., Lora, S., Carenza, M. Farmaco (1992) [Pubmed]
  13. Linked chromosome 16q13 chemokines, macrophage-derived chemokine, fractalkine, and thymus- and activation-regulated chemokine, are expressed in human atherosclerotic lesions. Greaves, D.R., Häkkinen, T., Lucas, A.D., Liddiard, K., Jones, E., Quinn, C.M., Senaratne, J., Green, F.R., Tyson, K., Boyle, J., Shanahan, C., Weissberg, P.L., Gordon, S., Ylä-Hertualla, S. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  14. Realtime transfer of live video images in parallel with three-dimensional modelling of the surgical field in computer-assisted telesurgery. Klapan, I., Simicić, L.j., Pasarić, K., Vlahusić, A., Risavi, R., Sruk, V., Schwarz, D., Barisić, J. Journal of telemedicine and telecare. (2002) [Pubmed]
  15. Immunologic responses to conjugates of antigen E in patients with ragweed hay fever. Norman, P.S., King, T.P., Alexander, J.F., Kagey-Sobotka, A., Lichtenstein, L.M. J. Allergy Clin. Immunol. (1984) [Pubmed]
  16. Synthesis and characterization of poly(L-alanine)-block-poly(ethylene glycol) monomethyl ether as amphiphilic biodegradable co-polymers. Zhang, G., Ma, J., Li, Y., Wang, Y. Journal of biomaterials science. Polymer edition. (2003) [Pubmed]
  17. MPEG digital compression and analogue videotape: a comparison of moving images and electroencephalogram data in epileptic patients. Akazawa, K., Kameyama, S., Mase, R., Yamayaka, T., Hashiba, M. Medical informatics and the Internet in medicine. (2004) [Pubmed]
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