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Gene Review

ICK  -  intestinal cell (MAK-like) kinase

Homo sapiens

Synonyms: ECO, Intestinal cell kinase, KIAA0936, LCK2, Laryngeal cancer kinase 2, ...
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Disease relevance of ICK

  • With regard to other carcinomas, ICK (50.0%) and SCK (47.1%) gave better results than did RCK (30.6%) [1].

High impact information on ICK

  • MAK and MRK require dual phosphorylation in a TDY motif catalyzed by an unidentified human threonine kinase and tyrosine autophosphorylation [2].
  • MRK preferentially phosphorylates R-P-X-S/T-P sites, with the preference for arginine at position -3 (P-3) being more stringent than for prolines at P-2 and P+1 [2].
  • The calculated structure of Ptu1 belongs to the inhibitory cystin knot structural family (ICK) that consists of a compact disulfide-bonded core from which four loops emerge [3].
  • Although the C-terminal double-stranded beta-sheet cross-linked by two disulfide bonds (II-V and IV-VI in HWTX-II, II-V and III-VI in the ICK molecules) is conserved both in HWTX-II and the ICK molecules, the structure of HWTX-II is unexpected absence of the cystine knot because of its unique disulfide linkage [4].
  • Using CLSM a strong fluorescence on the apical side of Caco-2 cell monolayers was observed, as a result of incubation with MRK 16 as primary and IgG Cy5 as secondary antibody [5].

Biological context of ICK


Anatomical context of ICK

  • The full-length hMRK protein was fused to C-terminal of GFP and expressed in Hela cells [6].
  • The hMRK was generally expressed a single approximately 6.3 kb transcript at a low level in a variety of tissues except at a high level in testis [6].
  • The depressed monocyte function (20.58 +/- 5% phago and 41.24 +/- 12.19% ICK; P < 0.05) was observed indicating a compromised host defense [7].
  • Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord [9].
  • This communication describes the cellular and ultrastructural localization in the central nervous system of P-glycoprotein (P-GP) recognized by a murine monoclonal antibody, MRK 16 [9].

Associations of ICK with chemical compounds

  • Thalidomide and ICK reduced in CBDL-rats significantly the BT rate (63% vs. 18%, 63% vs. 30%, P<0.01) [10].
  • Likewise, Curcumin and ICK suppressed NF-kappaB activation, but this did not reach significance in this experiment [10].
  • The following information was collected: hours between pain onset and streptokinase administration (TS), hours of pain after streptokinase administration (DP), initial and peak creatine phosphokinase levels (ICK and PCK), time to peak creatine phosphokinase, time to electrocardiographic ST segment resolution [11].

Analytical, diagnostic and therapeutic context of ICK


  1. Carcinoembryonic antigen and cancer: a comparative study. Azzolina, L.S., Fracastoro, G., Pisarri, N., Lievore, R., Cordiano, C., Tridente, G. Tumori. (1978) [Pubmed]
  2. Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase. Fu, Z., Larson, K.A., Chitta, R.K., Parker, S.A., Turk, B.E., Lawrence, M.W., Kaldis, P., Galaktionov, K., Cohn, S.M., Shabanowitz, J., Hunt, D.F., Sturgill, T.W. Mol. Cell. Biol. (2006) [Pubmed]
  3. Solution structure of Ptu1, a toxin from the assassin bug Peirates turpis that blocks the voltage-sensitive calcium channel N-type. Bernard, C., Corzo, G., Mosbah, A., Nakajima, T., Darbon, H. Biochemistry (2001) [Pubmed]
  4. The structure of spider toxin huwentoxin-II with unique disulfide linkage: evidence for structural evolution. Shu, Q., Lu, S.Y., Gu, X.C., Liang, S.P. Protein Sci. (2002) [Pubmed]
  5. P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels. Anderle, P., Niederer, E., Rubas, W., Hilgendorf, C., Spahn-Langguth, H., Wunderli-Allenspach, H., Merkle, H.P., Langguth, P. Journal of pharmaceutical sciences. (1998) [Pubmed]
  6. The identification and subcellular localization of human MRK. Yang, T., Jiang, Y., Chen, J. Biomol. Eng. (2002) [Pubmed]
  7. Quantitation of microbicidal activity of mononuclear phagocytes: an in vitro technique. Rege, N.N., Dahanukar, S.A. Journal of postgraduate medicine. (1993) [Pubmed]
  8. Expression of the multiple drug resistance gene (mdr-1) and epitope masking in chronic lymphatic leukaemia. Cumber, P.M., Jacobs, A., Hoy, T., Fisher, J., Whittaker, J.A., Tsuruo, T., Padua, R.A. Br. J. Haematol. (1990) [Pubmed]
  9. Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord. Sugawara, I., Hamada, H., Tsuruo, T., Mori, S. Jpn. J. Cancer Res. (1990) [Pubmed]
  10. The role of nuclear factor-kappa B in bacterial translocation in cholestatic rats. Weber-Mzell, D., Zaupa, P., Petnehazy, T., Kobayashi, H., Schimpl, G., Feierl, G., Kotanko, P., Höllwarth, M. Pediatr. Surg. Int. (2006) [Pubmed]
  11. Early prediction of left ventricular function in streptokinase-treated acute myocardial infarction. Fine, D.G., Weiss, A.T., Welber, S., Sapoznikov, D., Lotan, C., Applebaum, D., Ben-David, Y., Hasin, Y., Gotsman, M.S. Cardiology (1988) [Pubmed]
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