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Gene Review

WDTC1  -  WD and tetratricopeptide repeats 1

Homo sapiens

Synonyms: ADP, DCAF9, KIAA1037, WD and tetratricopeptide repeats protein 1
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Disease relevance of WDTC1

  • Further subclassification of cortical thymomas into organoid thymoma, conventional thymoma, and WDTC did not provide more information about clinical behavior [1].
  • CONCLUSIONS: In patients with WDTC and locoregional recurrence, US and US-FNB are the most sensitive methods in detecting local recurrence or regional lymph node metastases [2].
  • CONCLUSION: MR imaging is a sensitive and accurate technique for the detection of WDTC, particularly papillary carcinoma, metastatic to cervical lymph nodes [3].
  • BACKGROUND AND OBJECTIVE: Well-differentiated thyroid carcinoma (WDTC) is diagnosed in approximately 1.5% of thyroglossal duct cysts (TGDC) [4].
  • Five of seven relapses and six of seven deaths from thymoma occurred in patients with WDTC [5].

Psychiatry related information on WDTC1

  • CONCLUSION: These results suggest that QOL is not significantly impacted by the extent of surgery and that QOL should not be a factor in the decision-making process for the treatment of low-risk WDTC [6].

High impact information on WDTC1

  • The apoptotic indices of the thymomas and WDTCs were significantly lower than those of the HGTCs (P < .001), but there was no significant difference among each type of thymoma and the WDTCs. bcl-2 protein was expressed in the tumor cells of the medullary-type thymomas and of the HGTCs but not in the other types of thymoma or WDTC [7].
  • The former was further subclassified into organoid thymoma, conventional cortical thymoma, and well differentiated thymic carcinoma (WDTC) according to the systems of Pescarmona and Kirchner [1].
  • Current treatment strategies for pediatric patients with nonmedullary, well-differentiated thyroid carcinoma (WDTC) are derived from single-institution clinical cohorts, reports of extensive personal experience, and extrapolation of several common therapeutic practices for this tumor in adults [8].
  • (131)I is no longer a routine diagnostic modality, but it is widely used for remnant ablation after thyroidectomy for WDTC > 1 cm, under conditions of thyroxine withdrawal [9].
  • This case highlights the safety and effectiveness of rhTSH stimulated radioablation in pediatric WDTC, and proposes to invite controlled studies to further investigate pediatric rhTSH use, particularly in patients in whom thyroid hormone withdrawal is not a viable option [10].

Chemical compound and disease context of WDTC1


Anatomical context of WDTC1

  • In cases of WDTC admixed with cortical type, we observed increasing expression of E-CD as the tumor epithelium forms cohesive sheets [13].
  • Well-differentiated thymic carcinoma (WDTC) is a recently described epithelial tumour of the thymus previously classified as cortical or predominantly epithelial thymoma [14].

Analytical, diagnostic and therapeutic context of WDTC1

  • METHODS: The authors prospectively analyzed 24 patients with WDTC, negative results of whole-body (131)I scintigraphy, and elevated serum thyroglobulin concentrations [15].
  • OBJECTIVE: To assess the utility of 2-[(18)F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) to detect recurrent disease in the follow-up of patients with well-differentiated thyroid cancer (WDTC) who have negative diagnostic (131)I scans and abnormal thyroglobulin levels [15].
  • For the majority of patients, total/near-total thyroidectomy is currently recommended as the standard initial therapy for WDTC [8].
  • In the present study, we assess the efficacy of shortening the time of T4 withdrawal to only 3 weeks for detecting residual/recurrent WDTC as a sufficient serum TSH stimulus for obtaining a positive serum Tg result without a routine diagnostic whole body scan (WBS) [16].
  • We review the history, physical examination, laboratory, and radiographic evaluations that optimally prepare the surgeon to determine the ideal surgical thyroid and neck treatment for patients with WDTC [17].


  1. The clinicopathological correlation of epithelial subtyping in thymoma: a study of 112 consecutive cases. Pan, C.C., Wu, H.P., Yang, C.F., Chen, W.Y., Chiang, H. Hum. Pathol. (1994) [Pubmed]
  2. Value of preoperative diagnostic modalities in patients with recurrent thyroid carcinoma. Frilling, A., Görges, R., Tecklenborg, K., Gassmann, P., Bockhorn, M., Clausen, M., Broelsch, C.E. Surgery (2000) [Pubmed]
  3. MRI detection of cervical metastasis from differentiated thyroid carcinoma. Gross, N.D., Weissman, J.L., Talbot, J.M., Andersen, P.E., Wax, M.K., Cohen, J.I. Laryngoscope (2001) [Pubmed]
  4. Management of well-differentiated thyroid carcinoma presenting within a thyroglossal duct cyst. Patel, S.G., Escrig, M., Shaha, A.R., Singh, B., Shah, J.P. Journal of surgical oncology. (2002) [Pubmed]
  5. Thymoma. Histologic subclassification is an independent prognostic factor. Quintanilla-Martinez, L., Wilkins, E.W., Choi, N., Efird, J., Hug, E., Harris, N.L. Cancer (1994) [Pubmed]
  6. Quality of life in patients undergoing thyroid surgery. Shah, M.D., Witterick, I.J., Eski, S.J., Pinto, R., Freeman, J.L. The Journal of otolaryngology (2006) [Pubmed]
  7. Apoptosis, bcl-2 protein, and Fas antigen in thymic epithelial tumors. Tateyama, H., Eimoto, T., Tada, T., Inagaki, H., Hattori, H., Takino, H. Mod. Pathol. (1997) [Pubmed]
  8. Current controversies in the management of pediatric patients with well-differentiated nonmedullary thyroid cancer: a review. Hung, W., Sarlis, N.J. Thyroid (2002) [Pubmed]
  9. Role of 131I in the treatment of well differentiated thyroid cancer. Woodrum, D.T., Gauger, P.G. Journal of surgical oncology. (2005) [Pubmed]
  10. Successful use of recombinant human thyrotropin in the therapy of pediatric well-differentiated thyroid cancer. Ralli, M., Cohan, P., Lee, K. J. Endocrinol. Invest. (2005) [Pubmed]
  11. Bone mineral density in well-differentiated thyroid cancer patients treated with suppressive thyroxine: a systematic overview of the literature. Quan, M.L., Pasieka, J.L., Rorstad, O. Journal of surgical oncology. (2002) [Pubmed]
  12. Positron emission tomography for detecting iodine-131 nonvisualized metastasis of well-differentiated thyroid carcinoma: two case reports. Huang, T.S., Chieng, P.U., Chang, C.C., Yen, R.F. J. Endocrinol. Invest. (1998) [Pubmed]
  13. E-cadherin expression in thymomas. Yang, W.I., Yang, K.M., Hong, S.W., Kim, K.D. Yonsei Med. J. (1998) [Pubmed]
  14. Well-differentiated thymic carcinoma: a clinico-pathological study. Pescarmona, E., Rosati, S., Rendina, E.A., Venuta, F., Baroni, C.D. Virchows Archiv. A, Pathological anatomy and histopathology. (1992) [Pubmed]
  15. Preoperative diagnostic value of [(18)F] fluorodeoxyglucose positron emission tomography in patients with radioiodine-negative recurrent well-differentiated thyroid carcinoma. Frilling, A., Tecklenborg, K., Görges, R., Weber, F., Clausen, M., Broelsch, E.C. Ann. Surg. (2001) [Pubmed]
  16. Three-week thyroxine withdrawal thyroglobulin stimulation screening test to detect low-risk residual/recurrent well-differentiated thyroid carcinoma. Golger, A., Fridman, T.R., Eski, S., Witterick, I.J., Freeman, J.L., Walfish, P.G. J. Endocrinol. Invest. (2003) [Pubmed]
  17. Workup of well-differentiated thyroid carcinoma. Slough, C.M., Randolph, G.W. Cancer control : journal of the Moffitt Cancer Center. (2006) [Pubmed]
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