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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Organoids

 
 
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Disease relevance of Organoids

 

High impact information on Organoids

  • To determine the adhesion molecules involved in organoid formation we attempted to block this process by single cell suspensions of LIM 1863 reseeded in the presence of monoclonal antibodies [6].
  • Endothelium-dependent relaxations were also studied after incubation with L-arginine, L-sepiapterin, and liposome-entrapped superoxide dismutase (SOD) and after organoid culture with cis-vaccenic acid [7].
  • Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo [8].
  • Several EGFR agonists also stimulated Adam17(-/-) mammary organoid growth in culture, but only AREG was expressed abundantly in the developing ductal system in vivo [9].
  • HFH cultures maintained for 9 to 12 months produced grossly visible organoids containing ductular structures that stained for CK18, CK19, and AFP [10].
 

Biological context of Organoids

 

Anatomical context of Organoids

 

Associations of Organoids with chemical compounds

  • By contrast, no effect of estradiol could be evidenced on the [35S]methionine-labeled proteins released into the medium by the organoids [21].
  • Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids [22].
  • Sorted RMEC subpopulations, unsorted mixed cells, and undispersed organoids were seeded in Matrigel and cultured in either a complete hormone medium (CHM) with 10% fetal bovine serum, progesterone, estradiol, hydrocortisone, insulin, and prolactin or a serum-free medium containing EGF, insulin, hydrocortisone, and human transferrin [23].
  • The stimulatory effect of Ang II was much more pronounced in intact organoids that in endothelium-denuded organoids, indicating synergistic growth regulation by Ang II and endothelium-derived factors [24].
  • However, for endothelium-denuded organoids, medial [3H]-thymidine incorporation in the combined presence of Ang II and cilazaprilat was not significantly different from that in untreated controls [24].
 

Gene context of Organoids

  • Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids [25].
  • We further demonstrated that MDCK cells that express mutant EGFR that are competent in c-Src recruitment lose epithelial polarity in organoid cultures, whereas cells overexpressing the wild-type EGFR retain a polarized phenotype [26].
  • Microscopic examination revealed a fibroepithelial tumor formed by an organoid pattern of ductal structures with a very striking stromal appearance composed of extensive vascular proliferation and that demonstrated strong immunoreactivity for CD31, CD34, and Factor VIII [27].
  • Short term organoid cultures of both normal veins and human arteriosclerotic plaque also expressed tissue-associated IL1 activity upon stimulation with LPS but did not release significant soluble IL1 activity [28].
  • Isolated mammary organoids produced a 'stellate' type colony when PRL + P were present in the culture medium [29].
 

Analytical, diagnostic and therapeutic context of Organoids

References

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  7. Superoxide production, risk factors, and endothelium-dependent relaxations in human internal mammary arteries. Huraux, C., Makita, T., Kurz, S., Yamaguchi, K., Szlam, F., Tarpey, M.M., Wilcox, J.N., Harrison, D.G., Levy, J.H. Circulation (1999) [Pubmed]
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  9. Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Sternlicht, M.D., Sunnarborg, S.W., Kouros-Mehr, H., Yu, Y., Lee, D.C., Werb, Z. Development (2005) [Pubmed]
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  12. Characterization of rabbit kappa-casein cDNA: control of kappa-casein gene expression in vivo and in vitro. Bösze, Z., Devinoy, E., Puissant, C., Fontaine, M.L., Houdebine, L.M. J. Mol. Endocrinol. (1993) [Pubmed]
  13. Fibroblast growth factor 7, secreted by breast fibroblasts, is an interleukin-1beta-induced paracrine growth factor for human breast cells. Palmieri, C., Roberts-Clark, D., Assadi-Sabet, A., Coope, R.C., O'Hare, M., Sunters, A., Hanby, A., Slade, M.J., Gomm, J.J., Lam, E.W., Coombes, R.C. J. Endocrinol. (2003) [Pubmed]
  14. Dexamethasone induces chondrogenesis in organoid culture of cell mixtures from mouse embryos. Zimmermann, B., Cristea, R. Anat. Embryol. (1993) [Pubmed]
  15. Heterogeneity of so-called neuroendocrine lung tumors. Yesner, R. Exp. Mol. Pathol. (2001) [Pubmed]
  16. Three-dimensional polarization sensitizes hepatocytes to Fas/CD95 apoptotic signalling. Haouzi, D., Baghdiguian, S., Granier, G., Travo, P., Mangeat, P., Hibner, U. J. Cell. Sci. (2005) [Pubmed]
  17. Constitutive telomerase activity in cells with tissue-renewing potential from estrogen-regulated rat tissues. Bednarek, A.K., Chu, Y., Aldaz, C.M. Oncogene (1998) [Pubmed]
  18. Primary murine small intestinal epithelial cells, maintained in long-term culture, are susceptible to rotavirus infection. Macartney, K.K., Baumgart, D.C., Carding, S.R., Brubaker, J.O., Offit, P.A. J. Virol. (2000) [Pubmed]
  19. Induction of the endogenous whey acidic protein (Wap) gene and a Wap-myc hybrid gene in primary murine mammary organoids. Schoenenberger, C.A., Zuk, A., Groner, B., Jones, W., Andres, A.C. Dev. Biol. (1990) [Pubmed]
  20. Outcome of subcutaneous islet transplantation improved by polymer device. Juang, J.H., Bonner-Weir, S., Ogawa, Y., Vacanti, J.P., Weir, G.C. Transplantation (1996) [Pubmed]
  21. Effect of estradiol on nonmalignant human mammary cells in primary culture. Chambon, M., Cavalie-Barthez, G., Veith, F., Vignon, F., Hallowes, R., Rochefort, H. Cancer Res. (1984) [Pubmed]
  22. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Bates, R.C., Mercurio, A.M. Mol. Biol. Cell (2003) [Pubmed]
  23. Primary culture of flow cytometry-sorted rat mammary epithelial cell (RMEC) subpopulations in a reconstituted basement membrane, Matrigel. Kim, N.D., Oberley, T.D., Clifton, K.H. Exp. Cell Res. (1993) [Pubmed]
  24. Endothelium-modulated proliferation of medial smooth muscle cells: influence of angiotensin II and converting enzyme inhibition. Hahn, A.W., Schmidt, R., Kern, F., Resink, T.J., Bühler, F.R. Eur. Heart J. (1995) [Pubmed]
  25. Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Bates, R.C., Goldsmith, J.D., Bachelder, R.E., Brown, C., Shibuya, M., Oettgen, P., Mercurio, A.M. Curr. Biol. (2003) [Pubmed]
  26. The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation. Kim, H., Chan, R., Dankort, D.L., Zuo, D., Najoukas, M., Park, M., Muller, W.J. Oncogene (2005) [Pubmed]
  27. Aggressive giant fibroepithelial lesion with unusual vascular stroma--a case report. Hanna, W., AL-Maghrabi, J., Malik, A. Mod. Pathol. (2003) [Pubmed]
  28. Functional significance of human vascular smooth muscle cell-derived interleukin 1 in paracrine and autocrine regulation pathways. Loppnow, H., Libby, P. Exp. Cell Res. (1992) [Pubmed]
  29. Differential response of normal rat mammary epithelial cells to mammogenic hormones and EGF. McGrath, M., Palmer, S., Nandi, S. J. Cell. Physiol. (1985) [Pubmed]
  30. Galectin 1 is involved in vascular smooth muscle cell proliferation. Moiseeva, E.P., Javed, Q., Spring, E.L., de Bono, D.P. Cardiovasc. Res. (2000) [Pubmed]
  31. Three-dimensional mammary primary culture model systems. Ip, M.M., Darcy, K.M. Journal of mammary gland biology and neoplasia. (1996) [Pubmed]
  32. Inward remodeling follows chronic vasoconstriction in isolated resistance arteries. Bakker, E.N., van der Meulen, E.T., van den Berg, B.M., Everts, V., Spaan, J.A., VanBavel, E. J. Vasc. Res. (2002) [Pubmed]
  33. Characteristics of bovine parathyroid cell organoids in culture. Ridgeway, R.D., Hamilton, J.W., MacGregor, R.R. In Vitro Cell. Dev. Biol. (1986) [Pubmed]
  34. A case of synchronous double primary lung cancer with neuroendocrine features. Niho, S., Yokose, T., Nagai, K., Nishiwaki, Y., Kodama, T., Mukai, K. Jpn. J. Clin. Oncol. (1999) [Pubmed]
 
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