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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Organoids


High impact information on Organoids

  • To determine the adhesion molecules involved in organoid formation we attempted to block this process by single cell suspensions of LIM 1863 reseeded in the presence of monoclonal antibodies [6].
  • Endothelium-dependent relaxations were also studied after incubation with L-arginine, L-sepiapterin, and liposome-entrapped superoxide dismutase (SOD) and after organoid culture with cis-vaccenic acid [7].
  • Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo [8].
  • Several EGFR agonists also stimulated Adam17(-/-) mammary organoid growth in culture, but only AREG was expressed abundantly in the developing ductal system in vivo [9].
  • HFH cultures maintained for 9 to 12 months produced grossly visible organoids containing ductular structures that stained for CK18, CK19, and AFP [10].

Biological context of Organoids


Anatomical context of Organoids


Associations of Organoids with chemical compounds

  • By contrast, no effect of estradiol could be evidenced on the [35S]methionine-labeled proteins released into the medium by the organoids [21].
  • Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids [22].
  • Sorted RMEC subpopulations, unsorted mixed cells, and undispersed organoids were seeded in Matrigel and cultured in either a complete hormone medium (CHM) with 10% fetal bovine serum, progesterone, estradiol, hydrocortisone, insulin, and prolactin or a serum-free medium containing EGF, insulin, hydrocortisone, and human transferrin [23].
  • The stimulatory effect of Ang II was much more pronounced in intact organoids that in endothelium-denuded organoids, indicating synergistic growth regulation by Ang II and endothelium-derived factors [24].
  • However, for endothelium-denuded organoids, medial [3H]-thymidine incorporation in the combined presence of Ang II and cilazaprilat was not significantly different from that in untreated controls [24].

Gene context of Organoids

  • Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids [25].
  • We further demonstrated that MDCK cells that express mutant EGFR that are competent in c-Src recruitment lose epithelial polarity in organoid cultures, whereas cells overexpressing the wild-type EGFR retain a polarized phenotype [26].
  • Microscopic examination revealed a fibroepithelial tumor formed by an organoid pattern of ductal structures with a very striking stromal appearance composed of extensive vascular proliferation and that demonstrated strong immunoreactivity for CD31, CD34, and Factor VIII [27].
  • Short term organoid cultures of both normal veins and human arteriosclerotic plaque also expressed tissue-associated IL1 activity upon stimulation with LPS but did not release significant soluble IL1 activity [28].
  • Isolated mammary organoids produced a 'stellate' type colony when PRL + P were present in the culture medium [29].

Analytical, diagnostic and therapeutic context of Organoids


  1. E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture. Spancake, K.M., Anderson, C.B., Weaver, V.M., Matsunami, N., Bissell, M.J., White, R.L. Cancer Res. (1999) [Pubmed]
  2. Stage III thymoma: pattern of failure after surgery and postoperative radiotherapy and its implication for future study. Myojin, M., Choi, N.C., Wright, C.D., Wain, J.C., Harris, N., Hug, E.B., Mathisen, D.J., Lynch, T., Carey, R.W., Grossbard, M., Finkelstein, D.M., Grillo, H.C. Int. J. Radiat. Oncol. Biol. Phys. (2000) [Pubmed]
  3. Inhibition of VEGFR2 prevents DMBA-induced mammary tumor formation. Heffelfinger, S.C., Yan, M., Gear, R.B., Schneider, J., LaDow, K., Warshawsky, D. Lab. Invest. (2004) [Pubmed]
  4. Mucin histochemistry of pancreatic duct cell carcinoma, with special reference to organoid differentiation simulating gastric pyloric mucosa. Matsuzawa, K., Akamatsu, T., Katsuyama, T. Hum. Pathol. (1992) [Pubmed]
  5. Thymoma--morphologic subclassification correlates with invasiveness and immunohistologic features: a study of 122 cases. Quintanilla-Martinez, L., Wilkins, E.W., Ferry, J.A., Harris, N.L. Hum. Pathol. (1993) [Pubmed]
  6. Apoptosis induced by inhibition of intercellular contact. Bates, R.C., Buret, A., van Helden, D.F., Horton, M.A., Burns, G.F. J. Cell Biol. (1994) [Pubmed]
  7. Superoxide production, risk factors, and endothelium-dependent relaxations in human internal mammary arteries. Huraux, C., Makita, T., Kurz, S., Yamaguchi, K., Szlam, F., Tarpey, M.M., Wilcox, J.N., Harrison, D.G., Levy, J.H. Circulation (1999) [Pubmed]
  8. Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo. Thompson, J.A., Haudenschild, C.C., Anderson, K.D., DiPietro, J.M., Anderson, W.F., Maciag, T. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Sternlicht, M.D., Sunnarborg, S.W., Kouros-Mehr, H., Yu, Y., Lee, D.C., Werb, Z. Development (2005) [Pubmed]
  10. Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes. Lázaro, C.A., Croager, E.J., Mitchell, C., Campbell, J.S., Yu, C., Foraker, J., Rhim, J.A., Yeoh, G.C., Fausto, N. Hepatology (2003) [Pubmed]
  11. Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium. Taylor-Papadimitriou, J., Stampfer, M., Bartek, J., Lewis, A., Boshell, M., Lane, E.B., Leigh, I.M. J. Cell. Sci. (1989) [Pubmed]
  12. Characterization of rabbit kappa-casein cDNA: control of kappa-casein gene expression in vivo and in vitro. Bösze, Z., Devinoy, E., Puissant, C., Fontaine, M.L., Houdebine, L.M. J. Mol. Endocrinol. (1993) [Pubmed]
  13. Fibroblast growth factor 7, secreted by breast fibroblasts, is an interleukin-1beta-induced paracrine growth factor for human breast cells. Palmieri, C., Roberts-Clark, D., Assadi-Sabet, A., Coope, R.C., O'Hare, M., Sunters, A., Hanby, A., Slade, M.J., Gomm, J.J., Lam, E.W., Coombes, R.C. J. Endocrinol. (2003) [Pubmed]
  14. Dexamethasone induces chondrogenesis in organoid culture of cell mixtures from mouse embryos. Zimmermann, B., Cristea, R. Anat. Embryol. (1993) [Pubmed]
  15. Heterogeneity of so-called neuroendocrine lung tumors. Yesner, R. Exp. Mol. Pathol. (2001) [Pubmed]
  16. Three-dimensional polarization sensitizes hepatocytes to Fas/CD95 apoptotic signalling. Haouzi, D., Baghdiguian, S., Granier, G., Travo, P., Mangeat, P., Hibner, U. J. Cell. Sci. (2005) [Pubmed]
  17. Constitutive telomerase activity in cells with tissue-renewing potential from estrogen-regulated rat tissues. Bednarek, A.K., Chu, Y., Aldaz, C.M. Oncogene (1998) [Pubmed]
  18. Primary murine small intestinal epithelial cells, maintained in long-term culture, are susceptible to rotavirus infection. Macartney, K.K., Baumgart, D.C., Carding, S.R., Brubaker, J.O., Offit, P.A. J. Virol. (2000) [Pubmed]
  19. Induction of the endogenous whey acidic protein (Wap) gene and a Wap-myc hybrid gene in primary murine mammary organoids. Schoenenberger, C.A., Zuk, A., Groner, B., Jones, W., Andres, A.C. Dev. Biol. (1990) [Pubmed]
  20. Outcome of subcutaneous islet transplantation improved by polymer device. Juang, J.H., Bonner-Weir, S., Ogawa, Y., Vacanti, J.P., Weir, G.C. Transplantation (1996) [Pubmed]
  21. Effect of estradiol on nonmalignant human mammary cells in primary culture. Chambon, M., Cavalie-Barthez, G., Veith, F., Vignon, F., Hallowes, R., Rochefort, H. Cancer Res. (1984) [Pubmed]
  22. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Bates, R.C., Mercurio, A.M. Mol. Biol. Cell (2003) [Pubmed]
  23. Primary culture of flow cytometry-sorted rat mammary epithelial cell (RMEC) subpopulations in a reconstituted basement membrane, Matrigel. Kim, N.D., Oberley, T.D., Clifton, K.H. Exp. Cell Res. (1993) [Pubmed]
  24. Endothelium-modulated proliferation of medial smooth muscle cells: influence of angiotensin II and converting enzyme inhibition. Hahn, A.W., Schmidt, R., Kern, F., Resink, T.J., Bühler, F.R. Eur. Heart J. (1995) [Pubmed]
  25. Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Bates, R.C., Goldsmith, J.D., Bachelder, R.E., Brown, C., Shibuya, M., Oettgen, P., Mercurio, A.M. Curr. Biol. (2003) [Pubmed]
  26. The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation. Kim, H., Chan, R., Dankort, D.L., Zuo, D., Najoukas, M., Park, M., Muller, W.J. Oncogene (2005) [Pubmed]
  27. Aggressive giant fibroepithelial lesion with unusual vascular stroma--a case report. Hanna, W., AL-Maghrabi, J., Malik, A. Mod. Pathol. (2003) [Pubmed]
  28. Functional significance of human vascular smooth muscle cell-derived interleukin 1 in paracrine and autocrine regulation pathways. Loppnow, H., Libby, P. Exp. Cell Res. (1992) [Pubmed]
  29. Differential response of normal rat mammary epithelial cells to mammogenic hormones and EGF. McGrath, M., Palmer, S., Nandi, S. J. Cell. Physiol. (1985) [Pubmed]
  30. Galectin 1 is involved in vascular smooth muscle cell proliferation. Moiseeva, E.P., Javed, Q., Spring, E.L., de Bono, D.P. Cardiovasc. Res. (2000) [Pubmed]
  31. Three-dimensional mammary primary culture model systems. Ip, M.M., Darcy, K.M. Journal of mammary gland biology and neoplasia. (1996) [Pubmed]
  32. Inward remodeling follows chronic vasoconstriction in isolated resistance arteries. Bakker, E.N., van der Meulen, E.T., van den Berg, B.M., Everts, V., Spaan, J.A., VanBavel, E. J. Vasc. Res. (2002) [Pubmed]
  33. Characteristics of bovine parathyroid cell organoids in culture. Ridgeway, R.D., Hamilton, J.W., MacGregor, R.R. In Vitro Cell. Dev. Biol. (1986) [Pubmed]
  34. A case of synchronous double primary lung cancer with neuroendocrine features. Niho, S., Yokose, T., Nagai, K., Nishiwaki, Y., Kodama, T., Mukai, K. Jpn. J. Clin. Oncol. (1999) [Pubmed]
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