Disease relevance of SWAP70

• Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency [1].
• SWAP-70 was also detected on the surface of HIV-1 infected cells by flow cytometric analysis [2].
• Expression of the diffuse B-cell lymphoma family molecule SWAP-70 in human B-cell neoplasms: immunohistochemical study of 86 cases [3].

High impact information on SWAP70

• On stimulation by growth factors, cytoplasmic SWAP-70, which is dependent on PI(3)K but independent of Ras, moved to cell membrane rearrangements known as ruffles [4].
• Trans-acting factors - Ku70, Ku80 and possibly SWAP-70 - have been identified for the temporally related but not mechanistically related immunoglobulin heavy-chain class-switch [5].
• Association of SWAP-70 with the B cell antigen receptor complex [6].
• We suggest that SWAP-70 is involved not only in nuclear events but also in signaling in B cell activation [6].
• SWAP-70 identifies a transitional subset of actin filaments in motile cells [7].

Biological context of SWAP70

• Mapping of the SWAP70 gene to mouse chromosome 7 and human chromosome 11p15 [8].
• The results demonstrated that SWAP-70 consists of 12 exons spread over 89 kb at chromosome 11p15 [1].
• 2. SSCP analysis of the patient population revealed five polymorphic variants in the gene, one of which (Q505E) is an amino acid substitution in the putative nuclear export signal of SWAP-70 [1].
• In resting B cells, SWAP-70 is found in the cytoplasm; upon B-cell activation, it is transported both into the nucleus and to the cell membrane, where it is associated with the B-cell receptor complex and may play a role in signal transduction [8].
• SWAP-70 mediates lipid second-messenger signals to the cytoskeletal-organizing GTPase Rac, functioning as a guanine-nucleotide exchange factor [3].

Anatomical context of SWAP70

• We propose that SWAP-70 regulates the actin cytoskeleton as an effector or adaptor protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion [7].
• Here we report that the protein SWAP-70 associates transiently with macropinosomes in dendritic cells and NIH/3T3 fibroblasts [9].
• IBP is broadly expressed in the immune system and can be detected in both T and B cell compartments in contrast to SWAP-70 whose expression is primarily restricted to B cells [10].
• Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells [2].
• Differential regulation of germinal center genes, BCL6 and SWAP-70, during the course of MAIDS [11].

Associations of SWAP70 with chemical compounds

• These results identify SWAP-70 as a phosphoinositide 3-kinase signaling-dependent marker for a distinct, hitherto unrecognized, array of actin filaments [7].

Other interactions of SWAP70

• PNA-reactive cells decreased in concert with BCL6 while CD38 staining increased with SWAP-70 [11].

References