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Disease relevance of Schizophrenia


Psychiatry related information on Schizophrenia


High impact information on Schizophrenia


Chemical compound and disease context of Schizophrenia


Biological context of Schizophrenia


Anatomical context of Schizophrenia


Gene context of Schizophrenia

  • In contrast with two previous western reports, a recent study on a Chinese population found an association for allele 12 of the variable number tandem repeat (VNTR) in the second intron of the serotonin transporter (5-HTT) gene and schizophrenic disorders [17].
  • In 22 evaluable patients with a schizophrenic disorder chronically using clozapine, the CYP1A2 activity and the clozapine clearance were estimated [21].
  • Our results suggest that APOE alleles seem to be operative in the pathogenesis of schizophrenic disorders [22].
  • On the other hand, the Hp 2-2 value is not increased in the systematic schizophrenias, but it displays a relative overplus in the unsystematic forms [23].
  • By the study of hereditary serum protein markers in psychotic patients and normal controls, a surplus of Gc 1-1 (p less than 0.01) and transferrin B variants (p less than 0.0027) has been established in schizophrenias [23].
  • Schizophrenia susceptibility gene candidates  

Schizophrenia environmental risk factors

  • Risk and protective factor database  

Analytical, diagnostic and therapeutic context of Schizophrenia


  1. Autoantibodies against four kinds of neurotransmitter receptors in psychiatric disorders. Tanaka, S., Matsunaga, H., Kimura, M., Tatsumi, K., Hidaka, Y., Takano, T., Uema, T., Takeda, M., Amino, N. J. Neuroimmunol. (2003) [Pubmed]
  2. Multivariate modelling and the Defence Mechanism Test: a comparative study of defensive structures in borderline, other personality disorders and schizophrenic disorder. Sundbom, E., Kullgren, G. Acta psychiatrica Scandinavica. (1992) [Pubmed]
  3. Abnormal phosphatidylinositol-cycle of platelet membrane in schizophrenia--a preliminary study. Kaiya, H., Takeuchi, K., Namba, M., Imai, A., Nakashima, S., Nozawa, Y. Folia psychiatrica et neurologica japonica. (1984) [Pubmed]
  4. Use of the Booklet Category Test to assess abstract concept formation in schizophrenic disorders. Steindl, S.R., Boyle, G.J. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. (1995) [Pubmed]
  5. Experiences of a psychiatric outpatient team in Nicaragua. Mental health problems seen in a primary care setting. Penayo, U. Social psychiatry and psychiatric epidemiology. (1989) [Pubmed]
  6. Costs and benefits of two doses of fluphenazine. Marder, S.R., Van Putten, T., Mintz, J., McKenzie, J., Lebell, M., Faltico, G., May, P.R. Arch. Gen. Psychiatry (1984) [Pubmed]
  7. Dopaminergic mechanisms in the pathogenesis of schizophrenia. Goldstein, M., Deutch, A.Y. FASEB J. (1992) [Pubmed]
  8. Backward-masking deficit in adolescents with schizophrenic disorders or attention deficit hyperactivity disorder. Rund, B.R., Oie, M., Sundet, K. The American journal of psychiatry. (1996) [Pubmed]
  9. Physostigmine and lithium response in the schizophrenias. Edelstein, P., Schultz, J.R., Hirschowitz, J., Kanter, D.R., Garver, D.L. The American journal of psychiatry. (1981) [Pubmed]
  10. Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families. Schwab, S.G., Hoefgen, B., Hanses, C., Hassenbach, M.B., Albus, M., Lerer, B., Trixler, M., Maier, W., Wildenauer, D.B. Biol. Psychiatry (2005) [Pubmed]
  11. Dexamethasone suppression test and noradrenergic function in affective and schizophrenic disorders. Sora, I., Nishimon, K., Otsuki, S. Biol. Psychiatry (1986) [Pubmed]
  12. Plasma prostaglandin E2 metabolite--measured as 11-deoxy-15-keto-13,14-dihydro-11 beta,16 xi-cyclo-PGE2--in twins with schizophrenic disorder. Mathé, A.A., Eberhard, G., Sääf, J., Wetterberg, L. Biol. Psychiatry (1986) [Pubmed]
  13. Hyperasparaginemia in a schizophrenic patient. Perry, T.L., Wright, J.M., Hansen, S. Biol. Psychiatry (1983) [Pubmed]
  14. Effects of carbamazepine and valproate on haloperidol plasma levels and on psychopathologic outcome in schizophrenic patients. Hesslinger, B., Normann, C., Langosch, J.M., Klose, P., Berger, M., Walden, J. Journal of clinical psychopharmacology. (1999) [Pubmed]
  15. The use of benzodiazepines in the treatment of manic-depressive illness. Chouinard, G. The Journal of clinical psychiatry. (1988) [Pubmed]
  16. Association between tryptophan hydroxylase gene polymorphism (A218C) and schizophrenic disorders. Hong, C.J., Tsai, S.J., Wang, Y.C. Schizophr. Res. (2001) [Pubmed]
  17. Association for serotonin transporter gene variable number tandem repeat polymorphism and schizophrenic disorders. Tsai, S.J., Ouyang, W.C., Hong, C.J. Neuropsychobiology (2002) [Pubmed]
  18. Association study of onset age, attempted suicide, aggressive behavior, and schizophrenia with a serotonin 1B receptor (A-161T) genetic polymorphism. Hong, C.J., Pan, G.M., Tsai, S.J. Neuropsychobiology (2004) [Pubmed]
  19. Psychiatric aspects of epilepsy. Stevens, J.R. The Journal of clinical psychiatry. (1988) [Pubmed]
  20. Dysfunction of protein kinase FA/GSK-3 alpha in lymphocytes of patients with schizophrenic disorder. Yang, S.D., Yu, J.S., Lee, T.T., Yang, C.C., Ni, M.H., Yang, Y.Y. J. Cell. Biochem. (1995) [Pubmed]
  21. CYP1A2 activity is an important determinant of clozapine dosage in schizophrenic patients. Doude van Troostwijk, L.J., Koopmans, R.P., Vermeulen, H.D., Guchelaar, H.J. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2003) [Pubmed]
  22. Apolipoprotein E genotype in Korean schizophrenic patients. Lee, M.K., Park, A.J., Nam, B.Y., Min, K.J., Kee, B.S., Park, D.B. J. Korean Med. Sci. (2001) [Pubmed]
  23. Genetic markers for schizophrenic subgroups. Lange, V. Psychiatria clinica. (1982) [Pubmed]
  24. Attentional disturbances in patients with unipolar psychotic depression: a selective and sustained attention study. Politis, A., Lykouras, L., Mourtzouchou, P., Christodoulou, G.N. Comprehensive psychiatry. (2004) [Pubmed]
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