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Kcnc2  -  potassium voltage gated channel, Shaw...

Mus musculus

Synonyms: AW047325, B230117I07, KShIIIA, Kv3.2, Potassium voltage-gated channel subfamily C member 2, ...
 
 
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Disease relevance of Kcnc2

  • Moreover, we found that Kv3.2 -/- mice showed specific alterations in their cortical EEG patterns and an increased susceptibility to epileptic seizures consistent with an impairment of cortical inhibitory mechanisms [1].
 

High impact information on Kcnc2

 

Biological context of Kcnc2

 

Anatomical context of Kcnc2

 

Associations of Kcnc2 with chemical compounds

  • Moreover, in Kv3.1/Kv3.2 double knock-out (DKO) mice, the large effects of TEA were absent, spike-evoked GABA release was larger, and the PPR was lower than in wild-type mice [8].
 

Other interactions of Kcnc2

 

Analytical, diagnostic and therapeutic context of Kcnc2

  • The developmental expression of the voltage-gated potassium channel subunit, Kv3.2, and its localization within specific mouse hippocampal inhibitory interneuron populations were determined using immunoblotting and immunohistochemical techniques [5].
  • Using double immunofluorescence, Kv3.2 subunit expression was detected on subpopulations of GABAergic inhibitory interneurons [5].
  • We therefore generated mouse lines in which one of the Kv3 genes, Kv3.2, was disrupted by gene-targeting methods [1].
  • Western blot results showed that Kv3.2 expression became detectable in the lumbar cord from postnatal day 12, and increased steadily until reaching an adult level at postnatal day 28 [9].

References

  1. Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. Lau, D., Vega-Saenz de Miera, E.C., Contreras, D., Ozaita, A., Harvey, M., Chow, A., Noebels, J.L., Paylor, R., Morgan, J.I., Leonard, C.S., Rudy, B. J. Neurosci. (2000) [Pubmed]
  2. H2 histamine receptor-phosphorylation of Kv3.2 modulates interneuron fast spiking. Atzori, M., Lau, D., Tansey, E.P., Chow, A., Ozaita, A., Rudy, B., McBain, C.J. Nat. Neurosci. (2000) [Pubmed]
  3. The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells. Grissmer, S., Ghanshani, S., Dethlefs, B., McPherson, J.D., Wasmuth, J.J., Gutman, G.A., Cahalan, M.D., Chandy, K.G. J. Biol. Chem. (1992) [Pubmed]
  4. Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels. Yan, L., Herrington, J., Goldberg, E., Dulski, P.M., Bugianesi, R.M., Slaughter, R.S., Banerjee, P., Brochu, R.M., Priest, B.T., Kaczorowski, G.J., Rudy, B., Garcia, M.L. Mol. Pharmacol. (2005) [Pubmed]
  5. Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons. Tansey, E.P., Chow, A., Rudy, B., McBain, C.J. Hippocampus. (2002) [Pubmed]
  6. Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons. Erisir, A., Lau, D., Rudy, B., Leonard, C.S. J. Neurophysiol. (1999) [Pubmed]
  7. A unique role for Kv3 voltage-gated potassium channels in starburst amacrine cell signaling in mouse retina. Ozaita, A., Petit-Jacques, J., Völgyi, B., Ho, C.S., Joho, R.H., Bloomfield, S.A., Rudy, B. J. Neurosci. (2004) [Pubmed]
  8. Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse. Goldberg, E.M., Watanabe, S., Chang, S.Y., Joho, R.H., Huang, Z.J., Leonard, C.S., Rudy, B. J. Neurosci. (2005) [Pubmed]
  9. Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells. Song, Z.M., Hu, J., Rudy, B., Redman, S.J. Neuroscience (2006) [Pubmed]
 
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