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Gene Review

Hrh2  -  histamine receptor H2

Mus musculus

Synonyms: Gastric receptor I, H2R, H2r, HH2R, Histamine H2 receptor
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Disease relevance of Hrh2


High impact information on Hrh2


Chemical compound and disease context of Hrh2


Biological context of Hrh2


Anatomical context of Hrh2


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Regulatory relationships of Hrh2


Other interactions of Hrh2


Analytical, diagnostic and therapeutic context of Hrh2


  1. Inducible histamine protects mice from P. acnes-primed and LPS-induced hepatitis through H2-receptor stimulation. Yokoyama, M., Yokoyama, A., Mori, S., Takahashi, H.K., Yoshino, T., Watanabe, T., Watanabe, T., Ohtsu, H., Nishibori, M. Gastroenterology (2004) [Pubmed]
  2. Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells. Teuscher, C., Poynter, M.E., Offner, H., Zamora, A., Watanabe, T., Fillmore, P.D., Zachary, J.F., Blankenhorn, E.P. Am. J. Pathol. (2004) [Pubmed]
  3. Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. Kobayashi, T., Tonai, S., Ishihara, Y., Koga, R., Okabe, S., Watanabe, T. J. Clin. Invest. (2000) [Pubmed]
  4. Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment. Ashida, Y., Denda, M., Hirao, T. J. Invest. Dermatol. (2001) [Pubmed]
  5. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Jutel, M., Watanabe, T., Klunker, S., Akdis, M., Thomet, O.A., Malolepszy, J., Zak-Nejmark, T., Koga, R., Kobayashi, T., Blaser, K., Akdis, C.A. Nature (2001) [Pubmed]
  6. Ranitidine. Strum, W.B. JAMA (1983) [Pubmed]
  7. The H1 histamine receptor regulates allergic lung responses. Bryce, P.J., Mathias, C.B., Harrison, K.L., Watanabe, T., Geha, R.S., Oettgen, H.C. J. Clin. Invest. (2006) [Pubmed]
  8. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Takaishi, S., Cui, G., Frederick, D.M., Carlson, J.E., Houghton, J., Varro, A., Dockray, G.J., Ge, Z., Whary, M.T., Rogers, A.B., Fox, J.G., Wang, T.C. Gastroenterology (2005) [Pubmed]
  9. Role of histamine in natural killer cell-mediated resistance against tumor cells. Hellstrand, K., Asea, A., Hermodsson, S. J. Immunol. (1990) [Pubmed]
  10. Pharmacodynamic basis for the interaction of cimetidine with the bone marrow stem cells (CFUS). Byron, J.W. Exp. Hematol. (1980) [Pubmed]
  11. The relationship of histamine H2 receptor-bearing suppressor cells with the growth and metastasis of FANFT-induced bladder cancer. Babayan, R.K., Osband, M.E., Carpinito, G.A., Ho, Z.S., Cohen, E.B., Krane, R.J. Journal of surgical oncology. (1983) [Pubmed]
  12. Effects of SK&F 93479 on experimentally induced ventricular arrhythmias in dogs, rats and mice. Dai, S. Agents Actions (1984) [Pubmed]
  13. Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine decarboxylase knockout mice. Fitzsimons, C.P., Lazar-Molnar, E., Tomoskozi, Z., Buzás, E., Rivera, E.S., Falus, A. FEBS Lett. (2001) [Pubmed]
  14. Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene. Kobayashi, T., Inoue, I., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Watanabe, T. Genomics (1996) [Pubmed]
  15. GM-CSF in association with IL-1 triggers day-8 CFU-S into cell cycle: role of histamine. Piquet-Pellorce, C., Schneider, E., Dy, M. J. Cell. Physiol. (1991) [Pubmed]
  16. Prolonged histamine deficiency in histidine decarboxylase gene knockout mice affects leydig cell function. Mondillo, C., Falus, A., Pignataro, O., Pap, E. J. Androl. (2007) [Pubmed]
  17. Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice. Fukushima, Y., Shindo, T., Anai, M., Saitoh, T., Wang, Y., Fujishiro, M., Ohashi, Y., Ogihara, T., Inukai, K., Ono, H., Sakoda, H., Kurihara, Y., Honda, M., Shojima, N., Fukushima, H., Haraikawa-Onishi, Y., Katagiri, H., Shimizu, Y., Ichinose, M., Ishikawa, T., Omata, M., Nagai, R., Kurihara, H., Asano, T. Eur. J. Pharmacol. (2003) [Pubmed]
  18. T-cell suppression and contrasuppression induced by histamine H2 and H1 receptor agonists, respectively. Siegel, J.N., Schwartz, A., Askenase, P.W., Gershon, R.K. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  19. Evidence for the existence of a histamine H2-receptor in the mouse thyroid. Onaya, T., Hashizume, K., Sato, A., Takazawa, K., Akasu, F. Endocrinology (1977) [Pubmed]
  20. Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. Mobarakeh, J.I., Takahashi, K., Sakurada, S., Kuramasu, A., Yanai, K. Neuropharmacology (2006) [Pubmed]
  21. Crucial role of histamine for regulation of gastric acid secretion ascertained by histidine decarboxylase-knockout mice. Furutani, K., Aihara, T., Nakamura, E., Tanaka, S., Ichikawa, A., Ohtsu, H., Okabe, S. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  22. Involvement of histamine in growth of mouse and rat tumors: antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase. Bartholeyns, J., Bouclier, M. Cancer Res. (1984) [Pubmed]
  23. Histamine increases anti-CD3 induced IL-5 production of TH2-type T cells via histamine H2-receptors. Schmidt, J., Fleissner, S., Heimann-Weitschat, I., Lindstaedt, R., Szelenyi, I. Agents Actions (1994) [Pubmed]
  24. Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice. Mobarakeh, J.I., Takahashi, K., Sakurada, S., Nishino, S., Watanabe, H., Kato, M., Naghdi, N., Yanai, K. Pain (2005) [Pubmed]
  25. Involvement of the histaminergic system in the nociceptin-induced pain-related behaviors in the mouse spinal cord. Sakurada, S., Watanabe, H., Mizoguchi, H., Yonezawa, A., Orito, T., Katsuyama, S., Kuramasu, A., Sakurada, C., Yanai, K., Sakurada, T. Pain (2004) [Pubmed]
  26. Histamine H1 receptors are involved in mouse nasal allergic responses: a demonstration with H1 receptor-deficient mice. Kayasuga, R., Sugimoto, Y., Watanabe, T., Kamei, C. Int. Immunopharmacol. (2002) [Pubmed]
  27. Regulation of Con A-dependent cytokine production from CD4+ and CD8+ T lymphocytes by autosecretion of histamine. Sonobe, Y., Nakane, H., Watanabe, T., Nakano, K. Inflamm. Res. (2004) [Pubmed]
  28. Histamine receptors of the microvascular endothelium revealed in situ with a histamine-ferritin conjugate: characteristic high-affinity binding sites in venules. Heltianu, C., Simionescu, M., Simionescu, N. J. Cell Biol. (1982) [Pubmed]
  29. The effect of histamine receptor antagonists on specific and nonspecific suppression of experimental contact sensitivity. Mekori, Y.A., Bender, E.M., Zapata-Sirvent, R., Hansbrough, J.F., Claman, H.N. J. Allergy Clin. Immunol. (1985) [Pubmed]
  30. Blocking of histamine H2 receptors enhances parietal cell degeneration in the mouse stomach. Karam, S.M., Alexander, G. Histol. Histopathol. (2001) [Pubmed]
  31. Effects of histamine on functional maturation of dendritic cells. Pavlinkova, G., Yanagawa, Y., Kikuchi, K., Iwabuchi, K., Onoé, K. Immunobiology (2003) [Pubmed]
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