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Gene Review

Pvalb  -  parvalbumin

Mus musculus

Synonyms: PV, Parv, Parvalbumin alpha, Pva
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Disease relevance of Pvalb


Psychiatry related information on Pvalb


High impact information on Pvalb

  • This correlated with a loss of parvalbumin and carbonic anhydrase-positive neurons in the dorsal root ganglion [9].
  • Fluorescently labeled troponin C and parvalbumin did not bind to mitochondria on any other cellular organelle [10].
  • This reduction preferentially affects calretinin(+) (bipolar cells) and somatostatin(+) subtypes (for example, bitufted cells), whereas parvalbumin(+) subpopulations (basket cells and chandelier cells) seem to be unaffected [11].
  • Here we report that Runx3-deficient (Runx3(-/-)) mice displayed severe motor uncoordination and that few DRG neurons synthesized the proprioceptive neuronal marker parvalbumin [12].
  • In Bax(-/-)/NT3(-/-) mice, NT3-dependent neurons survived and expressed the proprioceptive neuronal marker parvalbumin [13].

Chemical compound and disease context of Pvalb


Biological context of Pvalb

  • However, similar to PV, delayed binding by CB leads to biphasic Ca2+ decay kinetics [16].
  • Calbindin, calretinin, or parvalbumin and 5-bromo-2'-deoxyuridine (BrdU) double labeling showed that calcium binding protein immunopositive neurons in gliotic CA1 area at 60 days were surviving instead of newly generated neurons [3].
  • Gene locus homology between chromosome 15 of the mouse and chromosome 22 of man (which carries the human PV gene) is discussed [17].
  • The restriction fragment patterns of DNA samples from 65 individual offspring of (C57BL/6 x SPE)F1 x C57BL/6 backcrosses were tested with the PV probe and matched, for linkage detection, to pre-existing patterns established with various RFLP probes on the same samples [17].
  • A cDNA derived from the 1100 nucleotide parvalbumin transcript was cloned and the sequence for the as yet unknown 3' extended trailer, generated by alternative polyadenylation, was determined [18].

Anatomical context of Pvalb

  • Parvalbumin immunostaining in interneurons was well preserved in all groups [19].
  • In the cerebella of 8-, 9-, and 12-week-old TM-B05 there was a progressive decrease in PV IR in Purkinje cells compared with nTM and TM-A02 [19].
  • In double knock-out mice, the absence of both PV and CB entailed a doubling of spine length, an increase in spine volume and spine surface, a higher spine density along the dendrites, as well as a more clustered spine distribution [20].
  • GABAergic neurons containing both PV and nNOS, i.e., PV-immunoreactive (-IR)/nNOS-IR neurons, were rare in Ammon's horn but frequent in the dentate gyrus (DG) [21].
  • The density of CB+ cells gradually increased in the pallial amygdala until the first postnatal week and appeared to decrease later, coinciding with the postnatal appearance of parvalbumin cells and raising the possibility of a partial phenotypic shift [22].

Associations of Pvalb with chemical compounds

  • Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex [23].
  • Undifferentiated P19-cells were stably transfected with the cDNA for CR, CB or PV, induced to differentiate, and then exposed to NMDA, a glutamate-receptor agonist [24].
  • Two of the three PV-transfected clones raised were vulnerable to NMDA-induced excitotoxicity; the third, which expressed the lowest level of PV, was protected to a similar degree as that found for the CR- and CB-transfected clones [24].
  • The cultures treated for 24 h with antisense oligos (CaB+PV) showed a significant decrease in [3H]-GABA uptake as compared with the cultures treated with lipofectin alone or with lipofectin + mismatched antisense oligos to CaB and PV mRNA [25].
  • The cells at different days in vitro were treated with antisense or mismatched antisense phosphorothioate oligonucleotides for CaB and PV mRNA (complexed with lipofectin) [25].
  • NaCl supplementation of Pvalb(-/-) mice increased calciuria at baseline and after furosemide [26].

Regulatory relationships of Pvalb


Other interactions of Pvalb

  • In the present study we determined PV and CaB expression (by immunohistochemical and immunoblot analyses) in Purkinje cells of transgenic mice (TM) expressing the human SCA-1 gene with an expanded (line B05) and normal (line A02) CAG tract, as well as in age-matched nontransgenic mice (nTM) [19].
  • This enhanced susceptibility was specific for enkephalin- and tachykinin-positive projection neurons, and also for parvalbumin-positive interneurons [31].
  • Thus, the structural gene for PV, designated Pva, maps to chromosome 15 of the mouse whereas the adr mutation shows no linkage with markers on this chromosome [17].
  • Cerebellar Purkinje cells of 6-week-old TM-B05, which exhibit no ataxia and even lack demonstrable Purkinje cell loss, also revealed reduction in PV IR [19].
  • Of these, mRNAs for parvalbumin and myosin heavy chain IIB were drastically downregulated in myotonic muscle (to < 10% of control) [18].

Analytical, diagnostic and therapeutic context of Pvalb


  1. Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system. Ringstedt, T., Kucera, J., Lendahl, U., Ernfors, P., Ibáñez, C.F. Development (1997) [Pubmed]
  2. Severe, early and selective loss of a subpopulation of GABAergic inhibitory neurons in experimental transmissible spongiform encephalopathies. Guentchev, M., Groschup, M.H., Kordek, R., Liberski, P.P., Budka, H. Brain Pathol. (1998) [Pubmed]
  3. Calcium binding protein containing neurons in the gliotic mouse hippocampus with special reference to their afferents from the medial septum and the entorhinal cortex. Tang, F.R., Chia, S.C., Jiang, F.L., Ma, D.L., Chen, P.M., Tang, Y.C. Neuroscience (2006) [Pubmed]
  4. Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures. Schwaller, B., Tetko, I.V., Tandon, P., Silveira, D.C., Vreugdenhil, M., Henzi, T., Potier, M.C., Celio, M.R., Villa, A.E. Mol. Cell. Neurosci. (2004) [Pubmed]
  5. Cortical neurons containing somatostatin- or parvalbumin-like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro. Weiss, J.H., Koh, J., Baimbridge, K.G., Choi, D.W. Neurology (1990) [Pubmed]
  6. Vermectomy enhances parvalbumin expression and improves motor performance in weaver mutant mice: an animal model for cerebellar ataxia. Grüsser-Cornehls, U., Grüsser, C., Bäurle, J. Neuroscience (1999) [Pubmed]
  7. Major effects of sensory experiences on the neocortical inhibitory circuits. Jiao, Y., Zhang, C., Yanagawa, Y., Sun, Q.Q. J. Neurosci. (2006) [Pubmed]
  8. Pharmacodynamic studies on Polypodium vulgare (Linn.). Mannan, A., Khan, R.A., Asif, M. Indian J. Exp. Biol. (1989) [Pubmed]
  9. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Ernfors, P., Lee, K.F., Kucera, J., Jaenisch, R. Cell (1994) [Pubmed]
  10. The identification of calmodulin-binding sites on mitochondria in cultured 3T3 cells. Pardue, R.L., Kaetzel, M.A., Hahn, S.H., Brinkley, B.R., Dedman, J.R. Cell (1981) [Pubmed]
  11. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Cobos, I., Calcagnotto, M.E., Vilaythong, A.J., Thwin, M.T., Noebels, J.L., Baraban, S.C., Rubenstein, J.L. Nat. Neurosci. (2005) [Pubmed]
  12. Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Inoue, K., Ozaki, S., Shiga, T., Ito, K., Masuda, T., Okado, N., Iseda, T., Kawaguchi, S., Ogawa, M., Bae, S.C., Yamashita, N., Itohara, S., Kudo, N., Ito, Y. Nat. Neurosci. (2002) [Pubmed]
  13. Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. Patel, T.D., Kramer, I., Kucera, J., Niederkofler, V., Jessell, T.M., Arber, S., Snider, W.D. Neuron (2003) [Pubmed]
  14. Expression of the mutant thyroid hormone receptor PV in the pituitary of transgenic mice leads to weight reduction. Zhu, X.G., Kaneshige, M., Parlow, A.F., Chen, E., Hunziker, R.D., McDonald, M.P., Cheng, S.Y. Thyroid (1999) [Pubmed]
  15. Ifenprodil attenuates the loss of parietal cortical parvalbumin immunoreactivity after focal cerebral ischemia in the mouse. O'Mahony, S., Noonan, D., Harkány, T., De Jong, G.I., Nyakas, C., Leonard, B.E. Neurobiology (Budapest, Hungary) (1997) [Pubmed]
  16. Mutational analysis of dendritic Ca2+ kinetics in rodent Purkinje cells: role of parvalbumin and calbindin D28k. Schmidt, H., Stiefel, K.M., Racay, P., Schwaller, B., Eilers, J. J. Physiol. (Lond.) (2003) [Pubmed]
  17. cDNA sequence and chromosomal localization of the mouse parvalbumin gene, Pva. Zühlke, C., Schöffl, F., Jockusch, H., Simon, D., Guénet, J.L. Genet. Res. (1989) [Pubmed]
  18. Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse. Schleef, M., Zühlke, C., Schöffl, F., Jockusch, H. Neuromuscul. Disord. (1994) [Pubmed]
  19. Reduced immunoreactivity to calcium-binding proteins in Purkinje cells precedes onset of ataxia in spinocerebellar ataxia-1 transgenic mice. Vig, P.J., Subramony, S.H., Burright, E.N., Fratkin, J.D., McDaniel, D.O., Desaiah, D., Qin, Z. Neurology (1998) [Pubmed]
  20. Alterations in Purkinje cell spines of calbindin D-28 k and parvalbumin knock-out mice. Vecellio, M., Schwaller, B., Meyer, M., Hunziker, W., Celio, M.R. Eur. J. Neurosci. (2000) [Pubmed]
  21. Patterns of expression of calcium binding proteins and neuronal nitric oxide synthase in different populations of hippocampal GABAergic neurons in mice. Jinno, S., Kosaka, T. J. Comp. Neurol. (2002) [Pubmed]
  22. Development of neurons and fibers containing calcium binding proteins in the pallial amygdala of mouse, with special emphasis on those of the basolateral amygdalar complex. Legaz, I., Olmos, L., Real, M.A., Guirado, S., Dávila, J.C., Medina, L. J. Comp. Neurol. (2005) [Pubmed]
  23. Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex. Dávila, J.C., Real, M.A., Olmos, L., Legaz, I., Medina, L., Guirado, S. J. Comp. Neurol. (2005) [Pubmed]
  24. Calretinin and calbindin D-28k delay the onset of cell death after excitotoxic stimulation in transfected P19 cells. D'Orlando, C., Fellay, B., Schwaller, B., Salicio, V., Bloc, A., Gotzos, V., Celio, M.R. Brain Res. (2001) [Pubmed]
  25. The effects of calbindin D-28K and parvalbumin antisense oligonucleotides on the survival of cultured Purkinje cells. Vig, P.J., McDaniel, D.O., Subramony, S.H., Qin, Z. Res. Commun. Mol. Pathol. Pharmacol. (1999) [Pubmed]
  26. Renal expression of parvalbumin is critical for NaCl handling and response to diuretics. Belge, H., Gailly, P., Schwaller, B., Loffing, J., Debaix, H., Riveira-Munoz, E., Beauwens, R., Devogelaer, J.P., Hoenderop, J.G., Bindels, R.J., Devuyst, O. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  27. Cortical interneuron fate determination: diverse sources for distinct subtypes? Xu, Q., de la Cruz, E., Anderson, S.A. Cereb. Cortex (2003) [Pubmed]
  28. Postnatal phenotype and localization of spinal cord V1 derived interneurons. Alvarez, F.J., Jonas, P.C., Sapir, T., Hartley, R., Berrocal, M.C., Geiman, E.J., Todd, A.J., Goulding, M. J. Comp. Neurol. (2005) [Pubmed]
  29. Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior. Pillai-Nair, N., Panicker, A.K., Rodriguiz, R.M., Gilmore, K.L., Demyanenko, G.P., Huang, J.Z., Wetsel, W.C., Maness, P.F. J. Neurosci. (2005) [Pubmed]
  30. A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons. Kinney, J.W., Davis, C.N., Tabarean, I., Conti, B., Bartfai, T., Behrens, M.M. J. Neurosci. (2006) [Pubmed]
  31. Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-d-aspartate receptors. Torres-Peraza, J., Pezzi, S., Canals, J.M., Gavald??, N., Garc??a-Mart??nez, J.M., P??rez-Navarro, E., Alberch, J. Neuroscience (2007) [Pubmed]
  32. Proprioceptive afferents survive in the masseter muscle of trkC knockout mice. Matsuo, S., Ichikawa, H., Silos-Santiago, I., Arends, J.J., Henderson, T.A., Kiyomiya, K., Kurebe, M., Jacquin, M.F. Neuroscience (2000) [Pubmed]
  33. Glutamate receptor subunit 3 (GluR3) immunoreactivity delineates a subpopulation of parvalbumin-containing interneurons in the rat hippocampus. Moga, D.E., Janssen, W.G., Vissavajjhala, P., Czelusniak, S.M., Moran, T.M., Hof, P.R., Morrison, J.H. J. Comp. Neurol. (2003) [Pubmed]
  34. Specific increase of genetic expression of parvalbumin in fast skeletal muscles of mdx mice. Gailly, P., Hermans, E., Octave, J.N., Gillis, J.M. FEBS Lett. (1993) [Pubmed]
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