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UL19  -  6 copies form hexons, 5 copies form pentons

Human herpesvirus 1

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Disease relevance of UL19


High impact information on UL19


Chemical compound and disease context of UL19


Biological context of UL19


Anatomical context of UL19


Associations of UL19 with chemical compounds

  • VP5, a 150 kDa major capsid protein that makes up both the penton and the bulk of the hexon subunits, has three domains: an upper diamond-shaped domain, a middle stem-like domain, and a lower anchoring domain [13].
  • Two are early (beta) promoters, for alkaline exonuclease and deoxyuridine triphosphate nucleotidohydrolase; the third promoter controls the major capsid protein transcript and is late (beta gamma) [14].

Other interactions of UL19


  1. DNA sequence of the major capsid protein gene of herpes simplex virus type 1. Davison, A.J., Scott, J.E. J. Gen. Virol. (1986) [Pubmed]
  2. Virus-specific interaction between the human cytomegalovirus major capsid protein and the C terminus of the assembly protein precursor. Beaudet-Miller, M., Zhang, R., Durkin, J., Gibson, W., Kwong, A.D., Hong, Z. J. Virol. (1996) [Pubmed]
  3. Alterations in virus protein synthesis and capsid production in infection with DI particles of herpesvirus. Henry, B.E., Newcomb, W.W., O'Callaghan, D.J. J. Gen. Virol. (1980) [Pubmed]
  4. The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments. Lamberti, C., Weller, S.K. J. Virol. (1998) [Pubmed]
  5. Three-dimensional localization of pORF65 in Kaposi's sarcoma-associated herpesvirus capsid. Lo, P., Yu, X., Atanasov, I., Chandran, B., Zhou, Z.H. J. Virol. (2003) [Pubmed]
  6. Altering the expression kinetics of VP5 results in altered virulence and pathogenesis of herpes simplex virus type 1 in mice. Tran, R.K., Lieu, P.T., Aguilar, S., Wagner, E.K., Bloom, D.C. J. Virol. (2002) [Pubmed]
  7. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. Nealon, K., Newcomb, W.W., Pray, T.R., Craik, C.S., Brown, J.C., Kedes, D.H. J. Virol. (2001) [Pubmed]
  8. Cell-free assembly of the herpes simplex virus capsid. Newcomb, W.W., Homa, F.L., Thomsen, D.R., Ye, Z., Brown, J.C. J. Virol. (1994) [Pubmed]
  9. YY1 is the cellular factor shown previously to bind to regulatory regions of several leaky-late (beta gamma, gamma 1) genes of herpes simplex virus type 1. Mills, L.K., Shi, Y., Millette, R.L. J. Virol. (1994) [Pubmed]
  10. Mutational analysis of sequences downstream of the TATA box of the herpes simplex virus type 1 major capsid protein (VP5/UL19) promoter. Huang, C.J., Goodart, S.A., Rice, M.K., Guzowski, J.F., Wagner, E.K. J. Virol. (1993) [Pubmed]
  11. The herpes simplex virus 1 UL 17 gene is required for localization of capsids and major and minor capsid proteins to intranuclear sites where viral DNA is cleaved and packaged. Taus, N.S., Salmon, B., Baines, J.D. Virology (1998) [Pubmed]
  12. Localization of the herpes simplex virus type 1 major capsid protein VP5 to the cell nucleus requires the abundant scaffolding protein VP22a. Nicholson, P., Addison, C., Cross, A.M., Kennard, J., Preston, V.G., Rixon, F.J. J. Gen. Virol. (1994) [Pubmed]
  13. Protein subunit structures in the herpes simplex virus A-capsid determined from 400 kV spot-scan electron cryomicroscopy. Zhou, Z.H., Prasad, B.V., Jakana, J., Rixon, F.J., Chiu, W. J. Mol. Biol. (1994) [Pubmed]
  14. A bi-functional reporter plasmid for the simultaneous transient expression assay of two herpes simplex virus promoters. Flanagan, W.M., Wagner, E.K. Virus Genes (1987) [Pubmed]
  15. Second site mutations in the N-terminus of the major capsid protein (VP5) overcome a block at the maturation cleavage site of the capsid scaffold proteins of herpes simplex virus type 1. Desai, P., Person, S. Virology (1999) [Pubmed]
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