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INPP5J  -  inositol polyphosphate-5-phosphatase J

Homo sapiens

Synonyms: INPP5, Inositol polyphosphate 5-phosphatase J, PIB5PA, PIPP, Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
 
 
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Disease relevance of PIB5PA

  • OBJECTIVES: To compare the convergent validity of two measures of pain (premature infant pain profile (PIPP) and crying, requires oxygen, increased vital signs, expression, and sleepless (CRIES)) in real life postoperative pain assessment in infants [1].
 

High impact information on PIB5PA

  • Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4 [2].
  • Together, these findings link PIPP remodeling to intracellular regulation of PMN function and suggest a role for PIPPs as lipid repressors in signal transduction, a novel mechanism that may also explain aspirin's suppressive actions in vivo in cell signaling [2].
  • We recently identified a novel polyisoprenyl phosphate (PIPP) signaling pathway and found that one of its components, presqualene diphosphate (PSDP), is a potent negative intracellular signal in PMN that regulates superoxide anion generation by several stimuli, including phosphatidic acid [2].
  • Data base searching demonstrated a novel 128-amino acid domain in the C terminus of SKIP, designated SKICH for SKIP carboxyl homology, which is also found in the 107-kDa 5-phosphatase PIPP and in members of the TRAF6-binding protein family [3].
  • The SKICH domain of the 5-phosphatase PIPP also mediated plasma membrane ruffle localization [3].
 

Biological context of PIB5PA

 

Anatomical context of PIB5PA

  • Together, these results indicate that PSDP is present in membranes and receptor activation rapidly initiates subcellular PIPP remodeling (i.e., conversion) and distribution predominantly to granule membranes [7].
  • To determine the relationship of polyisoprenyl phosphate (PIPP) remodeling and signaling to the activation state of human neutrophils (PMN), we examined the impact of leukotriene B(4) (LTB(4)) on the conversion of a unique bioactive isoprenoid (presqualene diphosphate: PSDP), recently identified as a novel endogenous signaling molecule [7].
 

Associations of PIB5PA with chemical compounds

  • We determined intracellular PIPP signaling by autocoids with opposing actions on PMN: leukotriene B4 (LTB4), a potent chemoattractant, and lipoxin A4 (LXA4), a 'stop signal' for recruitment [2].
  • When no glucose was given crying time was 57.3 s in the heel stick group and 26.8 s in the venepuncture group (P = 0.0041) and the mean PIPP scores were 8.4 and 6.0, respectively (P = 0.0458) [4].
  • Both sucrose groups had lower PIPP scores (single sucrose pain scores, 6.8-8.2, p = 0.07; repeated sucrose pain scores, 5.3-6. 2, p < 0.01) than water (pain scores 7.9-9.1), and in the last block, the repeated dose had lower scores than the single dose (6.2 vs. 8. 2, p < 0.05) [8].
  • Here, we determined the relationship between polyisoprenyl phosphate (PIPP) remodeling and PLD signaling and their impact in activation of PMN receptors by "pro-inflammatory" (leukotriene B4), and "anti-inflammatory" (aspirin-triggered lipoxinA4) ligands [5].
  • Pain assessments were made using validated pain measures including Neonatal Infant Pain Scale (NIPS), Neonatal Facial Action Coding System (NFCS), Premature Infant Pain Profile (PIPP) score and cry characteristics [9].
 

Analytical, diagnostic and therapeutic context of PIB5PA

References

  1. Postoperative pain assessment in the neonatal intensive care unit. McNair, C., Ballantyne, M., Dionne, K., Stephens, D., Stevens, B. Archives of disease in childhood. Fetal and neonatal edition. (2004) [Pubmed]
  2. Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. Levy, B.D., Fokin, V.V., Clark, J.M., Wakelam, M.J., Petasis, N.A., Serhan, C.N. FASEB J. (1999) [Pubmed]
  3. Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. Gurung, R., Tan, A., Ooms, L.M., McGrath, M.J., Huysmans, R.D., Munday, A.D., Prescott, M., Whisstock, J.C., Mitchell, C.A. J. Biol. Chem. (2003) [Pubmed]
  4. Oral glucose and venepuncture reduce blood sampling pain in newborns. Eriksson, M., Gradin, M., Schollin, J. Early Hum. Dev. (1999) [Pubmed]
  5. A novel polyisoprenyl phosphate signaling cascade in human neutrophils. Levy, B.D., Serhan, C.N. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
  6. Analgesic effects of oral sucrose and pacifier during eye examinations for retinopathy of prematurity. Mitchell, A., Stevens, B., Mungan, N., Johnson, W., Lobert, S., Boss, B. Pain management nursing : official journal of the American Society of Pain Management Nurses. (2004) [Pubmed]
  7. Polyisoprenyl phosphate signaling: topography in human neutrophils. Levy, B.D., Serhan, C.N. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  8. Effect of repeated doses of sucrose during heel stick procedure in preterm neonates. Johnston, C.C., Stremler, R., Horton, L., Friedman, A. Biol. Neonate (1999) [Pubmed]
  9. Venepuncture versus heel lance for blood sampling in term neonates. Shah, V., Ohlsson, A. Cochrane database of systematic reviews (Online) (2004) [Pubmed]
  10. Premature Infant Pain Profile: development and initial validation. Stevens, B., Johnston, C., Petryshen, P., Taddio, A. The Clinical journal of pain. (1996) [Pubmed]
  11. Efficacy of sucrose to reduce pain in premature infants during eye examinations for retinopathy of prematurity. Gal, P., Kissling, G.E., Young, W.O., Dunaway, K.K., Marsh, V.A., Jones, S.M., Shockley, D.H., Weaver, N.L., Carlos, R.Q., Ransom, J.L. The Annals of pharmacotherapy. (2005) [Pubmed]
  12. Feeding and oral glucose--additive effects on pain reduction in newborns. Gradin, M., Finnström, O., Schollin, J. Early Hum. Dev. (2004) [Pubmed]
  13. Comparison of pain responses of premature infants to the heelstick between containment and swaddling. Huang, C.M., Tung, W.S., Kuo, L.L., Ying-Ju, C. The journal of nursing research : JNR. (2004) [Pubmed]
  14. Opioids for neonates receiving mechanical ventilation. Bellù, R., de Waal, K.A., Zanini, R. Cochrane database of systematic reviews (Online) (2005) [Pubmed]
 
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