Gene Review:
Tlx3 - T cell leukemia, homeobox 3
Mus musculus
Synonyms:
Homeobox TLX-3, Homeobox protein Hox-11L2, Hox11l2, Respiratory neuron homeobox protein, Rnx, ...
- Rnx deficiency results in congenital central hypoventilation. Shirasawa, S., Arata, A., Onimaru, H., Roth, K.A., Brown, G.A., Horning, S., Arata, S., Okumura, K., Sasazuki, T., Korsmeyer, S.J. Nat. Genet. (2000)
- Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. Qian, Y., Shirasawa, S., Chen, C.L., Cheng, L., Ma, Q. Genes Dev. (2002)
- Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Qian, Y., Fritzsch, B., Shirasawa, S., Chen, C.L., Choi, Y., Ma, Q. Genes Dev. (2001)
- Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells. Kondo, T., Sheets, P.L., Zopf, D.A., Aloor, H.L., Cummins, T.R., Chan, R.J., Hashino, E. Proc. Natl. Acad. Sci. U. S. A. (2008)
- Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Cheng, L., Arata, A., Mizuguchi, R., Qian, Y., Karunaratne, A., Gray, P.A., Arata, S., Shirasawa, S., Bouchard, M., Luo, P., Chen, C.L., Busslinger, M., Goulding, M., Onimaru, H., Ma, Q. Nat. Neurosci. (2004)
- Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Cheng, L., Samad, O.A., Xu, Y., Mizuguchi, R., Luo, P., Shirasawa, S., Goulding, M., Ma, Q. Nat. Neurosci. (2005)
- In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla. Onimaru, H., Arata, A., Arata, S., Shirasawa, S., Cleary, M.L. Brain Res. Dev. Brain Res. (2004)
- Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Mizuguchi, R., Kriks, S., Cordes, R., Gossler, A., Ma, Q., Goulding, M. Nat. Neurosci. (2006)
- Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Ding, Y.Q., Yin, J., Kania, A., Zhao, Z.Q., Johnson, R.L., Chen, Z.F. Development (2004)
- Onset of Tlx-3 expression in the chick cerebellar cortex correlates with the morphological development of fissures and delineates a posterior transverse boundary. Logan, C., Millar, C., Bharadia, V., Rouleau, K. J. Comp. Neurol. (2002)