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Gene Review

DDC  -  dopa decarboxylase (aromatic L-amino acid...

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Disease relevance of DDC


High impact information on DDC


Biological context of DDC


Anatomical context of DDC


Associations of DDC with chemical compounds

  • The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation of aldosterone mediated by adrenocorticotropin (ACTH) [10].
  • Metabolic conversion of L-dopa by AADC is thus preserved in the case of an approach via the basolateral side of the proximal tubular cells [11].
  • Gamma-L-glutamyl-L-dopa (or gludopa), a dopamine (DA) prodrug, is selectively metabolized in vivo by the kidney through the sequential action of two renal enzymes, gamma-glutamyl transpeptidase (gamma-GT) and aromatic L-amino acid decarboxylase (AADC) [11].
  • The accumulation rate of 3,4-dihydroxyphenylalanine (DOPA) in vivo in the retina of diabetic rats, measured following the administration of the AADC inhibitor m-hydroxybenzyl-hydrazine (100 mg/kg i.p.), was also unchanged [12].
  • The expressed enzyme activity was stereoselective for L-5-hydroxytryptophan and L-DOPA and blocked by NSD-1015 an inhibitor of AADC [9].

Other interactions of DDC


Analytical, diagnostic and therapeutic context of DDC


  1. Ferrochelatase and N-alkylated porphyrins. Cole, S.P., Marks, G.S. Mol. Cell. Biochem. (1984) [Pubmed]
  2. Comparison of characteristics of bovine aromatic L-amino acid decarboxylase with human enzyme. Nasrin, S., Ichinose, H., Nagatsu, T. Biochim. Biophys. Acta (1992) [Pubmed]
  3. A single gene codes for aromatic L-amino acid decarboxylase in both neuronal and non-neuronal tissues. Albert, V.R., Allen, J.M., Joh, T.H. J. Biol. Chem. (1987) [Pubmed]
  4. Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex. Imaoka, T., Date, I., Ohmoto, T., Nagatsu, T. Hum. Gene Ther. (1998) [Pubmed]
  5. Lack of regulation of aromatic L-amino acid decarboxylase in intact bovine chromaffin cells. Waymire, J.C., Haycock, J.W. J. Neurochem. (2002) [Pubmed]
  6. Regulation of the chromaffin granule catecholamine transporter in cultured bovine adrenal medullary cells: stimulus-biosynthesis coupling. Desnos, C., Laran, M.P., Scherman, D. J. Neurochem. (1992) [Pubmed]
  7. Deduced amino acid sequence of bovine aromatic L-amino acid decarboxylase: homology to other decarboxylases. Kang, U.J., Joh, T.H. Brain Res. Mol. Brain Res. (1990) [Pubmed]
  8. 2',3'-Dideoxycytidine preferentially inhibits in vitro growth of granulocyte-macrophage colony-forming cells from patients with chronic myeloid leukemia. Cinatl, J., Cinatl, J., Gussetis, E.S., Nemeth, U., Mainke, M., Kornhuber, B., Brendel, M., Doerr, H.W. Chemotherapy. (1991) [Pubmed]
  9. Expression of cloned aromatic L-amino acid decarboxylase in Xenopus laevis oocytes. Gudehithlu, K.P., Duchemin, A.M., Silvia, C.P., Neff, N.H., Hadjiconstantinou, M. Neurochem. Int. (1992) [Pubmed]
  10. Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures. Cozza, E.N., Vila, M.C., Gomez-Sanchez, C.E. Steroids (1993) [Pubmed]
  11. Metabolism and vascular effects of gamma-L-glutamyl-L-dopa on the isolated rat kidney. Barthelmebs, M., Caillette, A., Ehrhardt, J.D., Velly, J., Imbs, J.L. Kidney Int. (1990) [Pubmed]
  12. Alterations in the retinal dopaminergic neuronal system in rats with streptozotocin-induced diabetes. Nishimura, C., Kuriyama, K. J. Neurochem. (1985) [Pubmed]
  13. Insulin-like growth factor-I enhances tyrosine hydroxylase activation in bovine chromaffin cells. Dahmer, M.K., Hart, P.M., Perlman, R.L. J. Neurochem. (1991) [Pubmed]
  14. Purification of aromatic L-amino acid decarboxylase from bovine brain with a monoclonal antibody. Nishigaki, I., Ichinose, H., Tamai, K., Nagatsu, T. Biochem. J. (1988) [Pubmed]
  15. Prolactin regulation of dopaminergic neurons in the infundibulum pituitary stalk of bull calves. Zinn, S.A., Lookingland, K.J., Chapin, L.T., Moore, K.E., Tucker, H.A. Proc. Soc. Exp. Biol. Med. (1990) [Pubmed]
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