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Chemical Compound Review

Lopac-H-9382     3-(hydrazinylmethyl)phenol

Synonyms: CHEMBL352205, SureCN160617, NSD-1015, AG-G-37173, BSPBio_002252, ...
 
 
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Disease relevance of Lopac-H-9382

 

High impact information on Lopac-H-9382

  • Indeed, DHEAS and ALLO increased catecholamine levels at 24 h, an effect blocked by L-2-methyl-3-(-4-hydroxyphenyl)alanine and 3-(hydrazinomethyl)phenol hydrochloride, inhibitors of tyrosine hydroxylase and L-aromatic amino acid decarboxylase, respectively, suggesting that this effect involved catecholamine synthesis [3].
  • 3-Hydroxybenzylhydrazine (NSD-1015; 100 mg/kg, i.p.), an AADC inhibitor, markedly increased the basal release of DOPA but produced no effect on DA [4].
  • Release of 3,4-dihydroxyphenylalanine was calcium and frequency dependent, inhibited by a-m-L-p-tyrosine (an inhibitor of tyrosine hydroxylase) and augmented by 3-hydroxybenzylhydrazine (an inhibitor of aromatic amino acid decarboxylase) [5].
  • Addition of the aromatic amino acid decarboxylase inhibitor, 3-hydroxybenzylhydrazine (NSD 1015), prevented the formation of N-acetylcompounds from L-[3H]tyrosine, without resulting in an accumulation of label in L-DOPA [6].
  • This study was done to determine if the concentration of the hydrazine derivative 3-hydroxybenzylhydrazine (NSD-1015), a drug frequently used in vitro to inhibit AAAD, could be adjusted such that it would inhibit that enzyme, but would not simultaneously inhibit a second, potentially important enzyme, monoamine oxidase (MAO; EC 1.4.3.4) [7].
 

Biological context of Lopac-H-9382

 

Anatomical context of Lopac-H-9382

 

Associations of Lopac-H-9382 with other chemical compounds

 

Gene context of Lopac-H-9382

 

Analytical, diagnostic and therapeutic context of Lopac-H-9382

References

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  2. Acute effects of L-tryptophan on tryptophan hydroxylation rate in brain regions (hypothalamus and medulla) of rainbow trout (Oncorhynchus mykiss). Aldegunde, M., Soengas, J.L., rozas, G. J. Exp. Zool. (2000) [Pubmed]
  3. Dehydroepiandrosterone sulfate and allopregnanolone directly stimulate catecholamine production via induction of tyrosine hydroxylase and secretion by affecting actin polymerization. Charalampopoulos, I., Dermitzaki, E., Vardouli, L., Tsatsanis, C., Stournaras, C., Margioris, A.N., Gravanis, A. Endocrinology (2005) [Pubmed]
  4. Transmitter-like basal and K(+)-evoked release of 3,4-dihydroxyphenylalanine from the striatum in conscious rats studied by microdialysis. Nakamura, S., Goshima, Y., Yue, J.L., Misu, Y. J. Neurochem. (1992) [Pubmed]
  5. Dihydroxyphenylalanine and dopamine are released from portal vein together with noradrenaline and dihydroxyphenylglycol during nerve stimulation. Hunter, L.W., Rorie, D.K., Tyce, G.M. J. Neurochem. (1992) [Pubmed]
  6. Biosynthesis of N-acetyldopamine and N-acetyloctopamine by Schistocerca gregaria nervous tissue. Mir, A.K., Vaughan, P.F. J. Neurochem. (1981) [Pubmed]
  7. Inhibition of aromatic L-amino acid decarboxylase under physiological conditions: optimization of 3-hydroxybenzylhydrazine concentration to prevent concurrent inhibition of monoamine oxidase. Hunter, L.W., Rorie, D.K., Tyce, G.M. Biochem. Pharmacol. (1993) [Pubmed]
  8. Absence of serotonergic innervation from raphe nuclei in rat cerebral blood vessels--II. Lack of tryptophan hydroxylase activity in vitro. Mathiau, P., Reynier-Rebuffel, A.M., Issertial, O., Callebert, J., Decreme, C., Aubineau, P. Neuroscience (1993) [Pubmed]
  9. Impaired dopamine function and muscular rigidity induced by 6-aminonicotinamide in rats. Kehr, W., Halbhübner, K., Loos, D., Herken, H. Naunyn Schmiedebergs Arch. Pharmacol. (1978) [Pubmed]
  10. A9 and A10 dopamine nuclei as a site of action for effects of 8-OH-DPAT on locomotion in the rat. Hillegaart, V., Magnusson, O., Ahlenius, S. Pharmacol. Biochem. Behav. (2000) [Pubmed]
  11. Transfer of DOPA from the sympatho-adrenal system to the pancreas, liver and kidney via the blood circulation. Andén, N.E., Grabowska-Andén, M., Schwieler, J. Acta Physiol. Scand. (1989) [Pubmed]
  12. Synthesis and release of dopamine in rat brain: comparison between substantia nigra pars compacts, pars reticulata, and striatum. Nissbrandt, H., Sundström, E., Jonsson, G., Hjorth, S., Carlsson, A. J. Neurochem. (1989) [Pubmed]
  13. Agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (BP-554), at central 5-HT1A receptors. Matsuda, T., Seong, Y.H., Aono, H., Kanda, T., Baba, A., Saito, K., Tobe, A., Iwata, H. Eur. J. Pharmacol. (1989) [Pubmed]
  14. Biosynthesis of dopamine and serotonin in the rat brain after repeated cocaine injections: a microdissection mapping study. Baumann, M.H., Raley, T.J., Partilla, J.S., Rothman, R.B. Synapse (1993) [Pubmed]
  15. Acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on dopamine metabolism in mouse and rat striatum. Pileblad, E., Fornstedt, B., Clark, D., Carlsson, A. J. Pharm. Pharmacol. (1985) [Pubmed]
  16. Activity of tyrosine hydroxylase in the striatum of newborn piglets in response to hypocapnic hypoxia. Tammela, O., Pastuszko, A., Lajevardi, N.S., Delivoria-Papadopoulos, M., Wilson, D.F. J. Neurochem. (1993) [Pubmed]
 
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