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Gene Review

Ddc  -  dopa decarboxylase

Mus musculus

Synonyms: AADC, Aadc, Aromatic-L-amino-acid decarboxylase, DDC, DOPA decarboxylase, ...
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Disease relevance of Ddc

  • Significant increases in the number of lung adenomas in A/J mice were induced by multiple i.p. injections of cis-DDP and each of the DDCP and SHP complexes (total doses, 21 to 108 mumol/kg body weight) [1].
  • Similar treatments with cis-DDP caused a significant increase in the number of skin papillomas in female CD-1 mice given promoting treatments with croton oil; the DDCP and SHP complexes had little or no activity in this system [1].
  • The SHP complexes were the most reactive toward DNA and produced a greater reduction in the transforming activity of Bacillus subtilis DNA after 3-hr reaction times than did the DDP or DDCP complexes [1].
  • Our goal is to utilize antagonists of the serotonin-producing enzymes (tryptophan hydroxylase and AADC) as the basis for a chemotherapeutic approach to the treatment of carcinoid tumors, a rare tumor type characterized by the overproduction of serotonin [2].
  • Human L-Dopa decarboxylase (L-aromatic amino acid decarboxylase, DDC) has been purified from pheochromocytoma tissue, a benign tumor of the catecholamine-synthesizing cells of the adrenal medulla [3].

Psychiatry related information on Ddc

  • DDC caused only transient amnesia for passive avoidance training, while the amnestic effect of ANI remained constant at 24-hr and 1-week retention tests [4].

High impact information on Ddc


Chemical compound and disease context of Ddc


Biological context of Ddc


Anatomical context of Ddc


Associations of Ddc with chemical compounds


Regulatory relationships of Ddc


Other interactions of Ddc

  • In contrast, juxtaglomerular cells in the rat displayed a similar intensity of immunostaining for both AADC and TH [20].
  • To address this problem, the expression of DAT, VMAT2 and AADC was analysed at embryonic day 12.5 and 14 [26].
  • The mouse homologues, Ddc and Cobl, which map to the homologous imprinted region on proximal Chr 11, were also biallelically expressed in mice with uniparental maternal or paternal inheritance of this region [27].
  • Species-specific distribution of aromatic L-amino acid decarboxylase in the rodent adrenal gland, cerebellum, and olfactory bulb [20].
  • These neurons contained aromatic L-amino acid decarboxylase as well as TH, NSE and neurofilament immunoreactivities [28].

Analytical, diagnostic and therapeutic context of Ddc


  1. Mutagenicity, tumorigenicity, and electrophilic reactivity of the stereoisomeric platinum(II) complexes of 1,2-diaminocyclohexane. Leopold, W.R., Batzinger, R.P., Miller, E.C., Miller, J.A., Earhart, R.H. Cancer Res. (1981) [Pubmed]
  2. Enantiospecific syntheses of alpha-(fluoromethyl)tryptophan analogues: interactions with tryptophan hydroxylase and aromatic L-amino acid decarboxylase. Zembower, D.E., Gilbert, J.A., Ames, M.M. J. Med. Chem. (1993) [Pubmed]
  3. Use of radiolabeled monofluoromethyl-Dopa to define the subunit structure of human L-Dopa decarboxylase. Maneckjee, R., Baylin, S.B. Biochemistry (1983) [Pubmed]
  4. Neurochemical and behavioral effects of catecholamine and protein synthesis inhibitors in mice. Flood, J.F., Smith, G.E., Bennett, E.L., Alberti, M.H., Orme, A.E., Jarvik, M.E. Pharmacol. Biochem. Behav. (1986) [Pubmed]
  5. L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment. Wick, M.M. Science (1978) [Pubmed]
  6. An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers. Ippolito, J.E., Xu, J., Jain, S., Moulder, K., Mennerick, S., Crowley, J.R., Townsend, R.R., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: comparison with animal dopa decarboxylases. De Luca, V., Marineau, C., Brisson, N. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  8. Serotonin initiates and autoamplifies its own synthesis during mouse central nervous system development. De Vitry, F., Hamon, M., Catelon, J., Dubois, M., Thibault, J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  9. Transformation of catecholaminergic precursors into glucagon (A) cells in mouse embryonic pancreas. Teitelman, G., Joh, T.H., Reis, D.J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  10. Interaction of chelating agents with cadmium in mice and rats. Eybl, V., Sýkora, J., Koutenský, J., Caisová, D., Schwartz, A., Mertl, F. Environ. Health Perspect. (1984) [Pubmed]
  11. Elevated aromatic-L-amino acid decarboxylase in human carcinoid tumors. Gilbert, J.A., Bates, L.A., Ames, M.M. Biochem. Pharmacol. (1995) [Pubmed]
  12. Enhanced p53 gene transfer to human ovarian cancer cells using the cationic nonviral vector, DDC. Kim, C.K., Choi, E.J., Choi, S.H., Park, J.S., Haider, K.H., Ahn, W.S. Gynecol. Oncol. (2003) [Pubmed]
  13. SCH 23390 enhances exogenous L-DOPA decarboxylation in nigrostriatal neurons. Neff, N.H., Wemlinger, T.A., Hadjiconstantinou, M. Journal of neural transmission (Vienna, Austria : 1996) (2000) [Pubmed]
  14. Developmental toxicity of orally administered 2',3'-dideoxycytidine in mice. Lindström, P., Harris, M., Hoberman, A.M., Dunnick, J.K., Morrissey, R.E. Teratology (1990) [Pubmed]
  15. Tyrosine hydroxylase is expressed in a subpopulation of small dorsal root ganglion neurons in the adult mouse. Brumovsky, P., Villar, M.J., Hökfelt, T. Exp. Neurol. (2006) [Pubmed]
  16. Distribution of aromatic L-amino acid decarboxylase mRNA in mouse brain by in situ hybridization histology. Eaton, M.J., Gudehithlu, K.P., Quach, T., Silvia, C.P., Hadjiconstantinou, M., Neff, N.H. J. Comp. Neurol. (1993) [Pubmed]
  17. Expression of cell type-specific markers during pancreatic development in the mouse: implications for pancreatic cell lineages. Teitelman, G., Lee, J.K., Alpert, S. Cell Tissue Res. (1987) [Pubmed]
  18. Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin. Habecker, B.A., Klein, M.G., Sundgren, N.C., Li, W., Woodward, W.R. J. Neurosci. (2002) [Pubmed]
  19. Identification of the aromatic L-amino acid decarboxylase gene expression in various mice tissues and its modulation by immobilization stress in stellate ganglia. Kubovcakova, L., Krizanova, O., Kvetnansky, R. Neuroscience (2004) [Pubmed]
  20. Species-specific distribution of aromatic L-amino acid decarboxylase in the rodent adrenal gland, cerebellum, and olfactory bulb. Baker, H., Abate, C., Szabo, A., Joh, T.H. J. Comp. Neurol. (1991) [Pubmed]
  21. Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells. Hermanson, E., Joseph, B., Castro, D., Lindqvist, E., Aarnisalo, P., Wallén, A., Benoit, G., Hengerer, B., Olson, L., Perlmann, T. Exp. Cell Res. (2003) [Pubmed]
  22. Enhanced expression of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in cerebellar Purkinje cells of mouse after hyperosmotic stimuli. Sakai, M., Fujii, T., Karasawa, N., Arai, R., Nagatsu, I. Neurosci. Lett. (1995) [Pubmed]
  23. Distribution of glutamic acid decarboxylase mRNA in the forebrain of the rainbow trout as studied by in situ hybridization. Anglade, I., Mazurais, D., Douard, V., Le Jossic-Corcos, C., Mañanos, E.L., Michel, D., Kah, O. J. Comp. Neurol. (1999) [Pubmed]
  24. Regulation of tyrosine hydroxylase and aromatic L-amino acid decarboxylase by dopaminergic drugs. Cho, S., Neff, N.H., Hadjiconstantinou, M. Eur. J. Pharmacol. (1997) [Pubmed]
  25. Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro. Chung, S., Shin, B.S., Hwang, M., Lardaro, T., Kang, U.J., Isacson, O., Kim, K.S. Stem Cells (2006) [Pubmed]
  26. Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. Smits, S.M., Ponnio, T., Conneely, O.M., Burbach, J.P., Smidt, M.P. Eur. J. Neurosci. (2003) [Pubmed]
  27. DDC and COBL, flanking the imprinted GRB10 gene on 7p12, are biallelically expressed. Hitchins, M.P., Bentley, L., Monk, D., Beechey, C., Peters, J., Kelsey, G., Ishino, F., Preece, M.A., Stanier, P., Moore, G.E. Mamm. Genome (2002) [Pubmed]
  28. Development and persistence of catecholaminergic neurons in cultured explants of fetal murine vagus nerves and bowel. Baetge, G., Schneider, K.A., Gershon, M.D. Development (1990) [Pubmed]
  29. Dopa accumulates in the hypothalamic-hypophysial portal vessels and is taken into the anterior pituitary of NSD-1015-treated rodents. Telford, N., May, P.C., Sinha, Y.N., Porter, J.C., Finch, C.E. Neuroendocrinology (1992) [Pubmed]
  30. Immunocytochemical localization of aromatic L-amino acid decarboxylase in human, rat, and mouse bronchopulmonary and gastrointestinal endocrine cells. Lauweryns, J.M., Van Ranst, L. J. Histochem. Cytochem. (1988) [Pubmed]
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