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Chemical Compound Review

KST-1B4547     (2,3,5,6-tetrahydroxy-4- phosphonooxy...

Synonyms: CTK8I8075, AR-1B5038, AC1L1A2B, AC1Q6SH9, 47055-78-7
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High impact information on inositol 1,4-bisphosphate


Biological context of inositol 1,4-bisphosphate


Anatomical context of inositol 1,4-bisphosphate


Associations of inositol 1,4-bisphosphate with other chemical compounds


Gene context of inositol 1,4-bisphosphate


  1. Activation of a low specific activity form of DNA polymerase alpha by inositol-1,4-bisphosphate. Sylvia, V., Curtin, G., Norman, J., Stec, J., Busbee, D. Cell (1988) [Pubmed]
  2. Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. York, J.D., Veile, R.A., Donis-Keller, H., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase. York, J.D., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. Spiegelberg, B.D., Xiong, J.P., Smith, J.J., Gu, R.F., York, J.D. J. Biol. Chem. (1999) [Pubmed]
  5. A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase. López-Coronado, J.M., Bellés, J.M., Lesage, F., Serrano, R., Rodríguez, P.L. J. Biol. Chem. (1999) [Pubmed]
  6. Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates. Whitman, M.R., Epstein, J., Cantley, L. J. Biol. Chem. (1984) [Pubmed]
  7. Purification of a phospholipase C from rat liver cytosol that acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate. Fukui, T., Lutz, R.J., Lowenstein, J.M. J. Biol. Chem. (1988) [Pubmed]
  8. Characterization of D-myo-inositol 1,4,5-trisphosphate phosphatase in rat liver plasma membranes. Seyfred, M.A., Farrell, L.E., Wells, W.W. J. Biol. Chem. (1984) [Pubmed]
  9. Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver. Hansen, C.A., Mah, S., Williamson, J.R. J. Biol. Chem. (1986) [Pubmed]
  10. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Berridge, M.J., Dawson, R.M., Downes, C.P., Heslop, J.P., Irvine, R.F. Biochem. J. (1983) [Pubmed]
  11. Inositol 1,4,5-trisphosphate-induced release of sequestered Ca2+ from highly purified human platelet intracellular membranes. Authi, K.S., Crawford, N. Biochem. J. (1985) [Pubmed]
  12. Source of 3H-labeled inositol bis- and monophosphates in agonist-activated rat parotid acinar cells. Hughes, A.R., Putney, J.W. J. Biol. Chem. (1989) [Pubmed]
  13. Formation and metabolism of [3H]inositol phosphates in AR42J pancreatoma cells. Substance P-induced Ca2+ mobilization in the apparent absence of inositol 1,4,5-trisphosphate 3-kinase activity. Horstman, D.A., Takemura, H., Putney, J.W. J. Biol. Chem. (1988) [Pubmed]
  14. Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy. Patel, S., Yenush, L., Rodríguez, P.L., Serrano, R., Blundell, T.L. J. Mol. Biol. (2002) [Pubmed]
  15. Effects of aging and dietary restriction on DNA polymerases: gene expression, enzyme fidelity, and DNA excision repair. Srivastava, V., Tilley, R., Miller, S., Hart, R., Busbee, D. Exp. Gerontol. (1992) [Pubmed]
  16. Novel aspects of gonadotropin-releasing hormone action on inositol polyphosphate metabolism in cultured pituitary gonadotrophs. Morgan, R.O., Chang, J.P., Catt, K.J. J. Biol. Chem. (1987) [Pubmed]
  17. Prostaglandin F2 alpha stimulates inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate formation in bovine luteal cells. Duncan, R.A., Davis, J.S. Endocrinology (1991) [Pubmed]
  18. Effects of glucagon and Ca2+ on the metabolism of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in isolated rat hepatocytes and plasma membranes. Whipps, D.E., Armston, A.E., Pryor, H.J., Halestrap, A.P. Biochem. J. (1987) [Pubmed]
  19. Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor. Berridge, M.J., Heslop, J.P., Irvine, R.F., Brown, K.D. Biochem. J. (1984) [Pubmed]
  20. Inositol 1,4,5-trisphosphate-induced calcium release in permeabilized platelets is coupled to hydrolysis of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Eberhard, M., Erne, P. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
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