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Gene Review

RAB40AL  -  RAB40A, member RAS oncogene family-like

Homo sapiens

Synonyms: MRXSMP, RAR2, RLGP, Ras-like GTPase, Ras-related protein Rab-40A-like
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Disease relevance of RLGP


Psychiatry related information on RLGP


High impact information on RLGP


Biological context of RLGP


Anatomical context of RLGP


Associations of RLGP with chemical compounds

  • Western blot analysis showed increases (approximately 30-65%) in GDI-1 protein present in both cytosolic and membrane fractions that were significant in the 84-kDa Rab bound form, suggesting that memantine influences Ras-like GTPase function [15].

Other interactions of RLGP


  1. The Xq22 inversion breakpoint interrupted a novel Ras-like GTPase gene in a patient with Duchenne muscular dystrophy and profound mental retardation. Saito-Ohara, F., Fukuda, Y., Ito, M., Agarwala, K.L., Hayashi, M., Matsuo, M., Imoto, I., Yamakawa, K., Nakamura, Y., Inazawa, J. Am. J. Hum. Genet. (2002) [Pubmed]
  2. Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins. Movilla, N., Crespo, P., Bustelo, X.R. Oncogene (1999) [Pubmed]
  3. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. de Rooij, J., Zwartkruis, F.J., Verheijen, M.H., Cool, R.H., Nijman, S.M., Wittinghofer, A., Bos, J.L. Nature (1998) [Pubmed]
  4. Nucleocytoplasmic transport of macromolecules. Corbett, A.H., Silver, P.A. Microbiol. Mol. Biol. Rev. (1997) [Pubmed]
  5. Rho proteins play a critical role in cell migration during the early phase of mucosal restitution. Santos, M.F., McCormack, S.A., Guo, Z., Okolicany, J., Zheng, Y., Johnson, L.R., Tigyi, G. J. Clin. Invest. (1997) [Pubmed]
  6. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. Piddini, E., Schmid, J.A., de Martin, R., Dotti, C.G. EMBO J. (2001) [Pubmed]
  7. SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. Matunis, M.J., Wu, J., Blobel, G. J. Cell Biol. (1998) [Pubmed]
  8. Identification of functional domains within the septation initiation network kinase, Cdc7. Mehta, S., Gould, K.L. J. Biol. Chem. (2006) [Pubmed]
  9. Receptor-like protein-tyrosine phosphatase alpha specifically inhibits insulin-increased prolactin gene expression. Jacob, K.K., Sap, J., Stanley, F.M. J. Biol. Chem. (1998) [Pubmed]
  10. Differential regulation of the cell-surface targeting and function of beta- and alpha1-adrenergic receptors by Rab1 GTPase in cardiac myocytes. Filipeanu, C.M., Zhou, F., Fugetta, E.K., Wu, G. Mol. Pharmacol. (2006) [Pubmed]
  11. Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes. Cooper, P.R., Nowak, N.J., Higgins, M.J., Church, D.M., Shows, T.B. Genomics (1998) [Pubmed]
  12. Rab3D: a regulator of exocytosis in non-neuronal cells. Millar, A.L., Pavios, N.J., Xu, J., Zheng, M.H. Histol. Histopathol. (2002) [Pubmed]
  13. Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts. Peränen, J., Auvinen, P., Virta, H., Wepf, R., Simons, K. J. Cell Biol. (1996) [Pubmed]
  14. Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. Takeda, E., Hieda, M., Katahira, J., Yoneda, Y. Cell Struct. Funct. (2005) [Pubmed]
  15. Identification of genes regulated by memantine and MK-801 in adult rat brain by cDNA microarray analysis. Marvanová, M., Lakso, M., Wong, G. Neuropsychopharmacology (2004) [Pubmed]
  16. RAP1A GTP/GDP cycles determine the intracellular location of the late endocytic compartments and contribute to myogenic differentiation. Pizon, V., Méchali, F., Baldacci, G. Exp. Cell Res. (1999) [Pubmed]
  17. Recent advances in the regulation of the TOR pathway by insulin and nutrients. Avruch, J., Lin, Y., Long, X., Murthy, S., Ortiz-Vega, S. Current opinion in clinical nutrition and metabolic care. (2005) [Pubmed]
  18. Lambda clone B22 contains a 7676 bp genomic fragment of Saccharomyces cerevisiae chromosome VII spanning the VAM7-SPM2 intergenic region and containing three novel transcribed open reading frames. Kail, M., Jüttner, E., Vaux, D. Yeast (1996) [Pubmed]
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