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Csta  -  cystatin A (stefin A)

Rattus norvegicus

Synonyms: Cystatin-A, Cystatin-alpha, Epidermal stefin, Epidermal thiol proteinase inhibitor
 
 
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Disease relevance of Csta_predicted

 

High impact information on Csta_predicted

  • Lysine-rich phosphorylated cystatin alpha (P-cystatin alpha) from newborn rat epidermis is a good substrate for epidermal transglutaminase (TGase) and also one of the component proteins of cornified envelope in the stratum corneum [5].
  • Serum calcium in rats placed on a low calcium diet was decreased by treatment of E-64 or cystatin A, but not by CA-074 [6].
  • Thus phosphorylation of cystatin alpha by protein kinase C may play an important role in targeting cystatin alpha into KHG [7].
  • Treatment of sphingosine, a specific inhibitor of protein kinase C, markedly suppressed the incorporation of cystatin alpha into KHG [7].
  • The incorporation increased dose-dependently with the added cystatin alpha and was inhibited significantly by H-7, a specific inhibitor of PKC [8].
 

Biological context of Csta_predicted

 

Anatomical context of Csta_predicted

 

Associations of Csta_predicted with chemical compounds

  • Evidence of protease activity producing NH2-terminal truncated form of rat cystatin A in newborn rat epidermis [12].
  • The pI 4.7, 14.5 kDa hematoxylin-stainable protein (HSP) from rat epidermis inhibited the activities of the cysteine proteinases papain, ficin, cathepsins B, H and L with similar inhibitory characteristics as recombinant cystatin-alpha [13].
  • When phosphorylated cystatin alpha (P-cystatin alpha) was incubated with epidermal transglutaminase (TGase) and Ca2+ ions, polymerized protein was produced by formation of epsilon-(gamma-glutamyl)lysine cross-linking peptide bonds between lysine residues of cystatin alpha and glutamine residues of suitable protein(s) in the enzyme preparation [7].
  • Furthermore, 32P from [gamma-32P]ATP was incorporated into recombinant cystatin alpha by a protein kinase C (PKC) preparation in the presence of phosphatidyl serine and Ca2+ ions as co-factors [8].
  • The inactivation and degradation of L-lactate dehydrogenase by this partially purified enzyme were all markedly suppressed by a low level of cystatin alpha without inhibiting the activities of both cathepsins B and L [14].
 

Regulatory relationships of Csta_predicted

 

Other interactions of Csta_predicted

 

Analytical, diagnostic and therapeutic context of Csta_predicted

References

  1. Inhibition of growth and cysteine proteinase activity of Staphylococcus aureus V8 by phosphorylated cystatin alpha in skin cornified envelope. Takahashi, M., Tezuka, T., Katunuma, N. FEBS Lett. (1994) [Pubmed]
  2. Incorporation and degradation by kidney lysosomes of cystatin alpha injected intravenously. Ohshita, T., Ike, Y., Katunuma, N. Eur. J. Biochem. (1992) [Pubmed]
  3. Inhibition of cysteine protease and growth of Staphylococcus aureus V8 and poliovirus by phosphorylated cystatin alpha conjugate of skin. Takahashi, M., Tezuka, T., Korant, B., Katunuma, N. Biofactors (1999) [Pubmed]
  4. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line. Jones, B., Roberts, P.J., Faubion, W.A., Kominami, E., Gores, G.J. Am. J. Physiol. (1998) [Pubmed]
  5. Linkage between phosphorylated cystatin alpha and filaggrin by epidermal transglutaminase as a model of cornified envelope and inhibition of cathepsin L activity by cornified envelope and the conjugated cystatin alpha. Takahashi, M., Tezuka, T., Kakegawa, H., Katunuma, N. FEBS Lett. (1994) [Pubmed]
  6. Participation of cathepsin L on bone resorption. Kakegawa, H., Nikawa, T., Tagami, K., Kamioka, H., Sumitani, K., Kawata, T., Drobnic-Kosorok, M., Lenarcic, B., Turk, V., Katunuma, N. FEBS Lett. (1993) [Pubmed]
  7. Phosphorylated cystatin alpha is a natural substrate of epidermal transglutaminase for formation of skin cornified envelope. Takahashi, M., Tezuka, T., Katunuma, N. FEBS Lett. (1992) [Pubmed]
  8. Identification of hematoxylin-stainable protein in epidermal keratohyalin granules as phosphorylated cystatin alpha by protein kinase C. Takahashi, M., Tezuka, T., Towatari, T., Katunuma, N. FEBS Lett. (1991) [Pubmed]
  9. Amino acid sequence of rat epidermal thiol proteinase inhibitor. Takio, K., Kominami, E., Bando, Y., Katunuma, N., Titani, K. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  10. Molecular cloning, enhancement of expression efficiency and site-directed mutagenesis of rat epidermal cystatin A. Kaji, H., Yada-Wakatabe, R., Uehira, T., Terai, M., Takeda, A., Satoh, T., Samejima, T. J. Biochem. (1999) [Pubmed]
  11. Increase of cyclin B by overexpression of cystatin alpha. Hiwasa, T., Ma, J., Ike, Y., Katunuma, N., Sakiyama, S. Cell Biochem. Funct. (1995) [Pubmed]
  12. Evidence of protease activity producing NH2-terminal truncated form of rat cystatin A in newborn rat epidermis. Takeda, A., Nakamura, Y., Kaji, H., Samejima, T. Biol. Chem. Hoppe-Seyler (1990) [Pubmed]
  13. Properties and nature of a cysteine proteinase inhibitor located in keratohyalin granules of rat epidermis. Takahashi, M., Tezuka, T., Towatari, T., Katunuma, N. FEBS Lett. (1990) [Pubmed]
  14. Involvement of a cystatin-alpha-sensitive cysteine proteinase in the degradation of native L-lactate dehydrogenase and serum albumin by rat liver or kidney lysosomes. Ohshita, T., Kido, H. Eur. J. Biochem. (1994) [Pubmed]
  15. Biochemical properties of thiol proteinase inhibitor purified from psoriatic scales. Ohtani, O., Fukuyama, K., Epstein, W.L. J. Invest. Dermatol. (1982) [Pubmed]
  16. Filaggrin linker segment peptide and cystatin alpha are parts of a complex of the cornified envelope of epidermis. Takahashi, M., Tezuka, T., Katunuma, N. Arch. Biochem. Biophys. (1996) [Pubmed]
 
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