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TMPRSS11E  -  transmembrane protease, serine 11E

Homo sapiens

Synonyms: DESC1, Serine protease DESC1, TMPRSS11E2, Transmembrane protease serine 11E, Transmembrane protease serine 11E2, ...
 
 
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Disease relevance of TMPRSS11E

  • Comparison of DESC1 expression between primary squamous cell carcinoma and matched normal tissue shows that the level of DESC1 expression is reduced or absent in 11/12 SCC tissue specimens when compared to specimens of matched normal tissue [1].
  • An open false lumen with no thrombus formation was present in types I, II, III ca and III cr asc aortic dissection in 17%, 21%, 39%, and 27% respectively, although it was most pronounced in types III nc and III cr desc (75% and 78%) [2].
  • DESC was the most potent antagonist of spermine transport in ZR-75-1 human breast cancer cells, with Ki values of 5 [3].
  • Devastating epileptic encephalopathy in school-aged children (DESC): a pseudo encephalitis [4].
 

High impact information on TMPRSS11E

 

Biological context of TMPRSS11E

 

Anatomical context of TMPRSS11E

  • Tissue-specific expression studies further show that DESC1 expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testes [1].
  • Induction of normal keratinocyte differentiation by calcium challenge was accompanied by an increase in DESC1 expression (p = .002) [6].
  • METHODS.: Specimens of normal, dysplastic, and carcinomatous oropharyngeal mucosa (n = 31) were evaluated for DESC1 immunoreactivity using standard streptavidin-biotin immunoperoxidase techniques [6].
 

Associations of TMPRSS11E with chemical compounds

  • DESC1 possesses strong identity to the serine protease super-family [1].
  • While DESC strongly decreased the initial rate of [3H]spermidine transport, even a 40-fold molar excess of antagonist could not completely abolish intracellular spermidine accumulation [3].
  • While DESC and MESC were purely competitive inhibitors of putrescine transport, DEASC was a mixed competitive/noncompetitive antagonist [3].
 

Other interactions of TMPRSS11E

 

Analytical, diagnostic and therapeutic context of TMPRSS11E

References

  1. Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck. Lang, J.C., Schuller, D.E. Br. J. Cancer (2001) [Pubmed]
  2. Effect of medical and surgical therapy on aortic dissection evaluated by transesophageal echocardiography. Implications for prognosis and therapy. The European Cooperative Study Group on Echocardiography. Erbel, R., Oelert, H., Meyer, J., Puth, M., Mohr-Katoly, S., Hausmann, D., Daniel, W., Maffei, S., Caruso, A., Covino, F.E. Circulation (1993) [Pubmed]
  3. 2,2'-Dithiobis(N-ethyl-spermine-5-carboxamide) is a high affinity, membrane-impermeant antagonist of the mammalian polyamine transport system. Huber, M., Pelletier, J.G., Torossian, K., Dionne, P., Gamache, I., Charest-Gaudreault, R., Audette, M., Poulin, R. J. Biol. Chem. (1996) [Pubmed]
  4. Devastating epileptic encephalopathy in school-aged children (DESC): a pseudo encephalitis. Mikaeloff, Y., Jambaqué, I., Hertz-Pannier, L., Zamfirescu, A., Adamsbaum, C., Plouin, P., Dulac, O., Chiron, C. Epilepsy Res. (2006) [Pubmed]
  5. Molecular cloning and characterisation of DESC4, a new transmembrane serine protease. Behrens, M., Bufe, B., Schmale, H., Meyerhof, W. Cell. Mol. Life Sci. (2004) [Pubmed]
  6. Expression of the serine protease DESC1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression. Sedghizadeh, P.P., Mallery, S.R., Thompson, S.J., Kresty, L., Beck, F.M., Parkinson, E.K., Biancamano, J., Lang, J.C. Head & neck. (2006) [Pubmed]
 
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