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Gene Review

TAGLN3  -  transgelin 3

Homo sapiens

Synonyms: NP22, NP24, NP25, Neuronal protein 22, Neuronal protein NP25, ...
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Disease relevance of TAGLN3

  • To gain an insight into the biological functions of NP25, we first examined its subcellular localization in the human neuroblastoma cell line, SK-N-SH [1].

High impact information on TAGLN3


Biological context of TAGLN3

  • The sequence of the NP25 cDNA reveals a single open reading frame that encodes a primary translation product of 206 amino acids [6].
  • In contrast, a mutation to mimic persistent PKC phosphorylation resulted in a cellular morphology similar to that seen in wild-type hNP22 transfections [5].
  • Transfection of mutant hNP22 containing either a deletion of the putative actin-binding domain or deletion of a consensus protein kinase C (PKC) phosphorylation site (Ser-180) failed to induce process formation [5].
  • Further investigations using fluorescence resonance energy transfer (FRET) technique revealed intracellular binding of NP25 and actin [1].

Anatomical context of TAGLN3


Associations of TAGLN3 with chemical compounds


Other interactions of TAGLN3


Analytical, diagnostic and therapeutic context of TAGLN3


  1. Neuronal protein NP25 interacts with F-actin. Mori, K., Muto, Y., Kokuzawa, J., Yoshioka, T., Yoshimura, S., Iwama, T., Okano, Y., Sakai, N. Neurosci. Res. (2004) [Pubmed]
  2. Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain. Fan, L., Jaquet, V., Dodd, P.R., Chen, W., Wilce, P.A. J. Neurochem. (2001) [Pubmed]
  3. Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysis. Ding, Q., Vaynman, S., Souda, P., Whitelegge, J.P., Gomez-Pinilla, F. Eur. J. Neurosci. (2006) [Pubmed]
  4. Changes in neuronal protein 22 expression and cytoskeletal association in the alcohol-dependent and withdrawn rat brain. Depaz, I.M., de Las Heras, R., Kroon, P.A., Wilce, P.A. J. Neurosci. Res. (2005) [Pubmed]
  5. Neuronal protein 22 colocalises with both the microtubule and microfilament cytoskeleton in neurite-like processes. de Las Heras, R., Depaz, I., Jaquet, V., Kroon, P., Wilce, P.A. Brain Res. (2007) [Pubmed]
  6. The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations. Ren, W.Z., Ng, G.Y., Wang, R.X., Wu, P.H., O'Dowd, B.F., Osmond, D.H., George, S.R., Liew, C.C. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  7. Expression of hNP22 is altered in the frontal cortex and hippocampus of the alcoholic human brain. Depaz, I., Ito, M., Matsumoto, I., Niwa, S., Kroon, P., Wilce, P.A. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
  8. Expression of human neuronal protein 22, a novel cytoskeleton-associated protein, was decreased in the anterior cingulate cortex of schizophrenia. Ito, M., Depaz, I., Wilce, P., Suzuki, T., Niwa, S., Matsumoto, I. Neurosci. Lett. (2005) [Pubmed]
  9. Proteomic analysis of rat hippocampus and frontal cortex after chronic treatment with fluoxetine or putative novel antidepressants: CRF1 and NK1 receptor antagonists. Carboni, L., Vighini, M., Piubelli, C., Castelletti, L., Milli, A., Domenici, E. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2006) [Pubmed]
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