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Gene Review

mt  -  metallothionein-1

Danio rerio

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High impact information on mt


Biological context of mt


Anatomical context of mt


Associations of mt with chemical compounds

  • Surprisingly, mt1 and c-jun were the only genes displaying a differential induction after 21 days in liver, although this organ accumulated the highest cadmium concentration [4].
  • However, pre-treatment of embryos at the gastrula stage with 5-aza-2'-deoxycytidine induces MT synthesis following exposure to cadmium [8].
  • Whole-mount in situ hybridization showed that Zn induced mt expression in the olfactory pit, cerebellum, ceratobranchials, liver, chloride cells, and neuromasts of the lateral line [3].
  • The zebrafish mt gene consists of three exons encoding 60 amino acids with 20 conserved cysteine residues [9].
  • Using digoxigenin (DIG)-labeled anti-sense RNA probe, whole-mount in situ hybridization was performed to observe the expression pattern of zebrafish mt gene during embryonic and early larval stages [9].

Other interactions of mt


Analytical, diagnostic and therapeutic context of mt

  • RT-PCR result indicates the maternal contribution of Mt transcripts [9].


  1. Induction of metallothionein in human skin by routine exposure to sunlight: evidence for a systemic response and enhanced induction at certain body sites. Ablett, E., Whiteman, D.C., Boyle, G.M., Green, A.C., Parsons, P.G. J. Invest. Dermatol. (2003) [Pubmed]
  2. Effects of 17 beta-estradiol on levels and distribution of metallothionein and zinc in squirrelfish. Thompson, E.D., Olsson, P.E., Mayer, G.D., Haux, C., Walsh, P.J., Burge, E., Hogstrand, C. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
  3. Expression pattern of metallothionein, MTF-1 nuclear translocation, and its dna-binding activity in zebrafish (Danio rerio) induced by zinc and cadmium. Chen, W.Y., John, J.A., Lin, C.H., Chang, C.Y. Environ. Toxicol. Chem. (2007) [Pubmed]
  4. Comparative effects of direct cadmium contamination on gene expression in gills, liver, skeletal muscles and brain of the zebrafish (Danio rerio). Gonzalez, P., Baudrimont, M., Boudou, A., Bourdineaud, J.P. Biometals (2006) [Pubmed]
  5. Cloning of zebrafish metallothionein gene and characterization of its gene promoter region in HepG2 cell line. Yan, C.H., Chan, K.M. Biochim. Biophys. Acta (2004) [Pubmed]
  6. Metallothionein gene expression in zebrafish embryo-larvae and ZFL cell-line exposed to heavy metal ions. Chan, K.M., Ku, L.L., Chan, P.C., Cheuk, W.K. Mar. Environ. Res. (2006) [Pubmed]
  7. Stressor-dependent regulation of the heat shock response in zebrafish, Danio rerio. Airaksinen, S., Råbergh, C.M., Lahti, A., Kaatrasalo, A., Sistonen, L., Nikinmaa, M. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2003) [Pubmed]
  8. Changes in zinc, copper and metallothionein contents during oocyte growth and early development of the teleost Danio rerio (zebrafish). Riggio, M., Filosa, S., Parisi, E., Scudiero, R. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2003) [Pubmed]
  9. Expression of metallothionein gene during embryonic and early larval development in zebrafish. Chen, W.Y., John, J.A., Lin, C.H., Lin, H.F., Wu, S.C., Lin, C.H., Chang, C.Y. Aquat. Toxicol. (2004) [Pubmed]
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