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Gene Review

fgf1a  -  fibroblast growth factor 1a

Danio rerio

Synonyms: Acidic fibroblast growth factor, FGF-1, HBGF-1, Heparin-binding growth factor 1, SO:0000704, ...
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Disease relevance of fgf1


High impact information on fgf1


Biological context of fgf1


Anatomical context of fgf1

  • Expression of fgfs and retinaldehyde dehydrogenase 2 suggested that in the Cdx1a/4-defective embryos, the Fgf and RA signaling activities overlap in the posterior body and display opposing gradients, compared with those in the hindbrain region [4].
  • Interactions between Nodal/Activin and Fibroblast growth factor (Fgf) signalling pathways have long been thought to play an important role in mesoderm formation [5].
  • Recent work in the zebrafish has shown a requirement for fibroblast growth factor (Fgf) signaling and for the transcription factor variant hepatocyte nuclear factor 1 (vhnf1) in specification of rhombomeres 5 and 6 (r5+r6) [8].
  • We observed that FGF signaling is required for chordin expression but that it also acts via other mechanisms to repress BMP transcription during late blastula stages [9].
  • Endodermal FGF signaling is required for the differentiation and survival of postmigratory neural crest cells that form the pharyngeal skeleton [10].

Associations of fgf1 with chemical compounds

  • Furthermore, exogenous application of RA or Fgf alone is sufficient to induce hindbrain genes in gastrula stage tissues, suggesting that the two-signal requirement can be overcome under some conditions [11].

Other interactions of fgf1


Analytical, diagnostic and therapeutic context of fgf1


  1. Developmental genetic mechanisms of evolutionary tooth loss in cypriniform fishes. Stock, D.W., Jackman, W.R., Trapani, J. Development (2006) [Pubmed]
  2. Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites. Kawamura, A., Koshida, S., Hijikata, H., Sakaguchi, T., Kondoh, H., Takada, S. Genes Dev. (2005) [Pubmed]
  3. Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear. Asai, Y., Chan, D.K., Starr, C.J., Kappler, J.A., Kollmar, R., Hudspeth, A.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Shimizu, T., Bae, Y.K., Hibi, M. Development (2006) [Pubmed]
  5. Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations. Mathieu, J., Griffin, K., Herbomel, P., Dickmeis, T., Strähle, U., Kimelman, D., Rosa, F.M., Peyriéras, N. Development (2004) [Pubmed]
  6. A direct role for Fgf but not Wnt in otic placode induction. Phillips, B.T., Storch, E.M., Lekven, A.C., Riley, B.B. Development (2004) [Pubmed]
  7. Early fin primordia of zebrafish larvae regenerate by a similar growth control mechanism with adult regeneration. Kawakami, A., Fukazawa, T., Takeda, H. Dev. Dyn. (2004) [Pubmed]
  8. vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain. Wiellette, E.L., Sive, H. Development (2003) [Pubmed]
  9. Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction. Londin, E.R., Niemiec, J., Sirotkin, H.I. Dev. Biol. (2005) [Pubmed]
  10. An essential role for zebrafish Fgfrl1 during gill cartilage development. Hall, C., Flores, M.V., Murison, G., Crosier, K., Crosier, P. Mech. Dev. (2006) [Pubmed]
  11. An early Fgf signal required for gene expression in the zebrafish hindbrain primordium. Roy, N.M., Sagerström, C.G. Brain Res. Dev. Brain Res. (2004) [Pubmed]
  12. Fibroblast growth factor inhibits expression of neural markers in cultures of zebrafish early embryo cells. Singh, N.N., Fischer, K., Hedstrom, O., Barnes, D.W. Mar. Biotechnol. (2001) [Pubmed]
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