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Gene Review

Ambn  -  ameloblastin

Mus musculus

Synonyms: Ameloblastin
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  • Positive clones were confirmed by PCR analysis with ameloblastin-specific primers, and their size determined with vector-specific primers [6].
  • Cbfa1 was specifically shown to participate in the DNA-protein complexes between nuclear factors and the ameloblastin OSE2 site by supershift electrophoretic mobility shift assays [2].
  • We isolated the full-length human ameloblastin (AMBN) cDNA clone using reverse transcription-polymerase chain reaction (RT-PCR) methods [12].


  1. Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. Fukumoto, S., Kiba, T., Hall, B., Iehara, N., Nakamura, T., Longenecker, G., Krebsbach, P.H., Nanci, A., Kulkarni, A.B., Yamada, Y. J. Cell Biol. (2004) [Pubmed]
  2. Role of Cbfa1 in ameloblastin gene transcription. Dhamija, S., Krebsbach, P.H. J. Biol. Chem. (2001) [Pubmed]
  3. Cloning and characterization of the murine ameloblastin promoter. Dhamija, S., Liu, Y., Yamada, Y., Snead, M.L., Krebsbach, P.H. J. Biol. Chem. (1999) [Pubmed]
  4. Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel tooth-specific gene. Krebsbach, P.H., Lee, S.K., Matsuki, Y., Kozak, C.A., Yamada, K.M., Yamada, Y. J. Biol. Chem. (1996) [Pubmed]
  5. A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin overexpression. Paine, M.L., Wang, H.J., Luo, W., Krebsbach, P.H., Snead, M.L. J. Biol. Chem. (2003) [Pubmed]
  6. Identification and characterization of a cDNA for mouse ameloblastin. Simmons, D., Gu, T.T., Krebsbach, P.H., Yamada, Y., MacDougall, M. Connect. Tissue Res. (1998) [Pubmed]
  7. Ameloblastin and amelogenin expression in posnatal developing mouse molars. Torres-Quintana, M.A., Gaete, M., Hernandez, M., Farías, M., Lobos, N. Journal of oral science. (2005) [Pubmed]
  8. Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells. Zeichner-David, M., Chen, L.S., Hsu, Z., Reyna, J., Caton, J., Bringas, P. Eur. J. Oral Sci. (2006) [Pubmed]
  9. Dentin sialoprotein, dentin phosphoprotein, enamelysin and ameloblastin: tooth-specific molecules that are distinctively expressed during murine dental differentiation. Bègue-Kirn, C., Krebsbach, P.H., Bartlett, J.D., Butler, W.T. Eur. J. Oral Sci. (1998) [Pubmed]
  10. Enamel matrix protein interactions. Wang, H., Tannukit, S., Zhu, D., Snead, M.L., Paine, M.L. J. Bone Miner. Res. (2005) [Pubmed]
  11. Induction of amelogenin and ameloblastin by insulin and insulin-like growth factors (IGF-I and IGF-II) during embryonic mouse tooth development in vitro. Takahashi, K., Yamane, A., Bringas, P., Caton, J., Slavkin, H.C., Zeichner-David, M. Connect. Tissue Res. (1998) [Pubmed]
  12. Cloning and characterization of the human ameloblastin gene. Toyosawa, S., Fujiwara, T., Ooshima, T., Shintani, S., Sato, A., Ogawa, Y., Sobue, S., Ijuhin, N. Gene (2000) [Pubmed]
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