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Gene Review

shakB  -  shaking B

Drosophila melanogaster

Synonyms: CG12678, CG1321, CG15451, CG32508, CG34358, ...
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High impact information on shakB


Biological context of shakB


Anatomical context of shakB


Physical interactions of shakB


Other interactions of shakB


Analytical, diagnostic and therapeutic context of shakB

  • Immunocytochemistry with shaking-B peptide antisera demonstrates that the expression of shaking-B protein in the region of GFS synapses coincides temporally with the onset of synaptogenesis; expression persists thereafter [13].
  • Flies bearing the X-chromosome mutation Passover (Pas) fail to jump in response to a light-off stimulus, and electrical stimulation of the GF in the brain no longer elicits the normal response in the TTM [14].


  1. Passover: a gene required for synaptic connectivity in the giant fiber system of Drosophila. Krishnan, S.N., Frei, E., Swain, G.P., Wyman, R.J. Cell (1993) [Pubmed]
  2. Drosophila Shaking-B protein forms gap junctions in paired Xenopus oocytes. Phelan, P., Stebbings, L.A., Baines, R.A., Bacon, J.P., Davies, J.A., Ford, C. Nature (1998) [Pubmed]
  3. eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling. Starich, T.A., Lee, R.Y., Panzarella, C., Avery, L., Shaw, J.E. J. Cell Biol. (1996) [Pubmed]
  4. Molecular basis of intracistronic complementation in the Passover locus of Drosophila. Krishnan, S.N., Frei, E., Schalet, A.P., Wyman, R.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. Essential and neural transcripts from the Drosophila shaking-B locus are differentially expressed in the embryonic mesoderm and pupal nervous system. Crompton, D., Todman, M., Wilkin, M., Ji, S., Davies, J. Dev. Biol. (1995) [Pubmed]
  6. The Passover locus in Drosophila melanogaster: complex complementation and different effects on the giant fiber neural pathway. Baird, D.H., Schalet, A.P., Wyman, R.J. Genetics (1990) [Pubmed]
  7. The shaking B gene in Drosophila regulates the number of gap junctions between photoreceptor terminals in the lamina. Shimohigashi, M., Meinertzhagen, I.A. J. Neurobiol. (1998) [Pubmed]
  8. Null mutation in shaking-B eliminates electrical, but not chemical, synapses in the Drosophila giant fiber system: a structural study. Blagburn, J.M., Alexopoulos, H., Davies, J.A., Bacon, J.P. J. Comp. Neurol. (1999) [Pubmed]
  9. The shaker and shaking-B genes specify elements in the processing of gustatory information in Drosophila melanogaster. Balakrishnan, R., Rodrigues, V. J. Exp. Biol. (1991) [Pubmed]
  10. Gap junction proteins are not interchangeable in development of neural function in the Drosophila visual system. Curtin, K.D., Zhang, Z., Wyman, R.J. J. Cell. Sci. (2002) [Pubmed]
  11. Synaptogenesis in the giant-fibre system of Drosophila: interaction of the giant fibre and its major motorneuronal target. Jacobs, K., Todman, M.G., Allen, M.J., Davies, J.A., Bacon, J.P. Development (2000) [Pubmed]
  12. Localization of the genes shaking-B, small optic lobes, sluggish-A, stoned and stress-sensitive-C to a well-defined region on the X-chromosome of Drosophila melanogaster. Miklos, G.L., Kelly, L.E., Coombe, P.E., Leeds, C., Lefevre, G. J. Neurogenet. (1987) [Pubmed]
  13. Mutations in shaking-B prevent electrical synapse formation in the Drosophila giant fiber system. Phelan, P., Nakagawa, M., Wilkin, M.B., Moffat, K.G., O'Kane, C.J., Davies, J.A., Bacon, J.P. J. Neurosci. (1996) [Pubmed]
  14. Dendritic reduction in Passover, a Drosophila mutant with a defective giant fiber neuronal pathway. Baird, D.H., Koto, M., Wyman, R.J. J. Neurobiol. (1993) [Pubmed]
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