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Gene Review

TICAM2  -  toll-like receptor adaptor molecule 2

Homo sapiens

Synonyms: MyD88-4, TICAM-2, TIR domain-containing adapter molecule 2, TIRAP3, TIRP, ...
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Disease relevance of TICAM2


High impact information on TICAM2


Biological context of TICAM2

  • METHODS: One hundred and five human tali from 67 donors were used to determine the type and location of the most common lesions through gross examination, radiography, diffraction enhanced imaging, and histology. "tram-track lesions" also are described [6].

Anatomical context of TICAM2

  • Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway [7].
  • Fifty-two patients underwent immediate reconstruction (65.8%) and 25 were delayed (31.6%) reconstructions using either deep inferior epigastric artery perforator (DIEP) flaps (4 = 3.9%) or free TRAM flaps (97 = 96.0%) [8].
  • The purpose of this study was to determine the subtypes of breast reconstructive procedures and to evaluate the frequency and change in technique over time of free TRAM (transverse rectus abdominis muscle) flap breast reconstruction performed at one institution [8].
  • Further clinical experience with synthetic mesh for the entire abdominal wall after TRAM flap breast reconstruction [9].
  • Characterization of lesions of the talus and description of tram-track lesions [6].

Associations of TICAM2 with chemical compounds


Other interactions of TICAM2

  • Two additional adaptors are present in humans, termed Trif-related adaptor molecule (TRAM) and sterile alpha and HEAT-Armadillo motifs (SARM) [10].
  • Co-immunoprecipitation experiments suggest that TIRP is associated with IL-1 receptors [4].

Analytical, diagnostic and therapeutic context of TICAM2

  • In other patients reconstructions were done with a free TRAM-flap (n=26) LD-flap (n=27) or with a prosthesis only (n=1) [11].
  • Institutional review of free TRAM flap breast reconstruction [8].
  • The "Banked" TRAM: A Method to Insure Mastectomy Skin-Flap Survival [12].
  • This study compared the use of the internal mammary and thoracodorsal recipient vessels in a uniform group of patients who underwent delayed TRAM flap reconstruction after radiotherapy, focusing on usability rates and outcomes [13].
  • From 1988 to 2003, 14 VRAM and 18 TRAM flap neovaginal reconstructions were performed on 32 women during the course of 22 (68%) total pelvic exenterations, 8 (25%) partial exenterations, and 2 (6%) radical vulvovaginectomies [14].


  1. Elevated coagulation factor VIII, postoperative thrombosis and flap failure in late breast reconstruction with a free TRAM flap: a case report. Höijer, P., Olsson, E. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. (2006) [Pubmed]
  2. Unusual pattern of calcification in congenital toxoplasmosis: the tram-track sign. Surendrababu, N.R., Kuruvilla, K.A., Jana, A.K. Pediatric radiology. (2006) [Pubmed]
  3. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Carty, M., Goodbody, R., Schröder, M., Stack, J., Moynagh, P.N., Bowie, A.G. Nat. Immunol. (2006) [Pubmed]
  4. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. Bin, L.H., Xu, L.G., Shu, H.B. J. Biol. Chem. (2003) [Pubmed]
  5. Dermal microcirculation of the free TRAM flap following adverse drug reaction. Rawlins, J.M., Riaz, M. Journal of reconstructive microsurgery (2007) [Pubmed]
  6. Characterization of lesions of the talus and description of tram-track lesions. Li, J., Jadin, K., Masuda, K., Sah, R., Muehleman, C. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (2006) [Pubmed]
  7. Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Harari, O.A., Alcaide, P., Ahl, D., Luscinskas, F.W., Liao, J.K. Circ. Res. (2006) [Pubmed]
  8. Institutional review of free TRAM flap breast reconstruction. Knight, M.A., Nguyen, D.T., Kobayashi, M.R., Evans, G.R. Annals of plastic surgery. (2006) [Pubmed]
  9. Further clinical experience with synthetic mesh for the entire abdominal wall after TRAM flap breast reconstruction. Moscona, R. Plast. Reconstr. Surg. (2005) [Pubmed]
  10. The Toll-IL-1 receptor adaptor family grows to five members. O'Neill, L.A., Fitzgerald, K.A., Bowie, A.G. Trends Immunol. (2003) [Pubmed]
  11. The surgical and oncological safety of immediate breast reconstruction. Mustonen, P., Lepistö, J., Papp, A., Berg, M., Pietiläinen, T., Kataja, V., Härmä, M. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (2004) [Pubmed]
  12. The "Banked" TRAM: A Method to Insure Mastectomy Skin-Flap Survival. Kovach, S.J., Georgiade, G.S. Annals of plastic surgery. (2006) [Pubmed]
  13. Choice of recipient vessels in delayed TRAM flap breast reconstruction after radiotherapy. Temple, C.L., Strom, E.A., Youssef, A., Langstein, H.N. Plast. Reconstr. Surg. (2005) [Pubmed]
  14. Rectus abdominis myocutaneous flaps for neovaginal reconstruction after radical pelvic surgery. Soper, J.T., Havrilesky, L.J., Secord, A.A., Berchuck, A., Clarke-Pearson, D.L. Int. J. Gynecol. Cancer (2005) [Pubmed]
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