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Gene Review

tsh  -  teashirt

Drosophila melanogaster

Synonyms: CG1374, Dmel\CG1374, Protein teashirt, T shirt, Tsh, ...
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High impact information on tsh


Biological context of tsh

  • teashirt (tsh) encodes a Drosophila zinc-finger protein [4].
  • By responding to signals as well as localized transcription regulators, the tsh transcription factor is produced in a spatial pattern distinct from any of the homeotic genes [5].
  • Instead, the maintenance of tsh repression requires Polycomb group (PcG) mediated gene silencing, which is dispensable for hth repression [6].
  • Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes [5].
  • Here we show that Wingless signalling promotes the phosphorylation and the nuclear accumulation of Teashirt [7].
  • In the developing eye disc, Tsh and Homothorax (Hth) cooperatively induces the expression of microRNA bantam, which promotes progenitor cell growth and prevents apoptosis. This tissue-specific DNA-binding event by Tsh+Hth mediates the function of co-activator Yorkie (Yki) and the Hippo signaling pathway. [8]

Anatomical context of tsh


Associations of tsh with chemical compounds


Physical interactions of tsh


Regulatory relationships of tsh

  • Tsh is ectopically induced at the border of Tollo-expressing clones [11].
  • Under mild heat-shock conditions, the Teashirt protein induces an almost complete transformation of the labial to prothoracic segmental identity, when expressed before 8 hours of development [12].
  • Second, Grunge acts positively to regulate teashirt expression in proximoventral parts of the leg [13].

Other interactions of tsh

  • Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes [14].
  • Thus, repression of Tsh defines the presumptive wing earlier in development than repression of Hth, which must therefore be considered a secondary event [15].
  • We also show that in tsh mutants, disco is expressed in the trunk segments, probably explaining the partial trunk to head transformation reported in these mutants, but more importantly demonstrating interactions between members of this regionalization network [16].
  • This process requires the binding of Teashirt to the C-terminal end of Armadillo [7].
  • Furthermore, teashirt and eyeless induce the expression of each other, suggesting that teashirt is part of the gene network that functions to specify eye identity [17].


  1. The gene teashirt is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs. Fasano, L., Röder, L., Coré, N., Alexandre, E., Vola, C., Jacq, B., Kerridge, S. Cell (1991) [Pubmed]
  2. The transcriptional repressor Brinker antagonizes Wingless signaling. Saller, E., Kelley, A., Bienz, M. Genes Dev. (2002) [Pubmed]
  3. Teashirt is required for transcriptional repression mediated by high Wingless levels. Waltzer, L., Vandel, L., Bienz, M. EMBO J. (2001) [Pubmed]
  4. Eye suppression, a novel function of teashirt, requires Wingless signaling. Singh, A., Kango-Singh, M., Sun, Y.H. Development (2002) [Pubmed]
  5. Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes. Mathies, L.D., Kerridge, S., Scott, M.P. Development (1994) [Pubmed]
  6. Differing strategies for the establishment and maintenance of teashirt and homothorax repression in the Drosophila wing. Zirin, J.D., Mann, R.S. Development (2004) [Pubmed]
  7. The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila. Gallet, A., Angelats, C., Erkner, A., Charroux, B., Fasano, L., Kerridge, S. EMBO J. (1999) [Pubmed]
  8. Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc. Peng, H.W., Slattery, M., Mann, R.S. Genes. Dev. (2009) [Pubmed]
  9. spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk. Wiellette, E.L., Harding, K.W., Mace, K.A., Ronshaugen, M.R., Wang, F.Y., McGinnis, W. Development (1999) [Pubmed]
  10. The role of Teashirt in proximal leg development in Drosophila: ectopic Teashirt expression reveals different cell behaviours in ventral and dorsal domains. Erkner, A., Gallet, A., Angelats, C., Fasano, L., Kerridge, S. Dev. Biol. (1999) [Pubmed]
  11. Ectopic expression of Tollo/Toll-8 antagonizes Dpp signaling and induces cell sorting in the Drosophila wing. Kim, S., Chung, S., Yoon, J., Choi, K.W., Yim, J. Genesis (2006) [Pubmed]
  12. Homeotic complex and teashirt genes co-operate to establish trunk segmental identities in Drosophila. de Zulueta, P., Alexandre, E., Jacq, B., Kerridge, S. Development (1994) [Pubmed]
  13. Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development. Erkner, A., Roure, A., Charroux, B., Delaage, M., Holway, N., Coré, N., Vola, C., Angelats, C., Pagès, F., Fasano, L., Kerridge, S. Development (2002) [Pubmed]
  14. Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes. Andrew, D.J., Horner, M.A., Petitt, M.G., Smolik, S.M., Scott, M.P. EMBO J. (1994) [Pubmed]
  15. Repression of Teashirt marks the initiation of wing development. Wu, J., Cohen, S.M. Development (2002) [Pubmed]
  16. An interactive network of zinc-finger proteins contributes to regionalization of the Drosophila embryo and establishes the domains of HOM-C protein function. Robertson, L.K., Bowling, D.B., Mahaffey, J.P., Imiolczyk, B., Mahaffey, J.W. Development (2004) [Pubmed]
  17. Targeted expression of teashirt induces ectopic eyes in Drosophila. Pan, D., Rubin, G.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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