Disease relevance of Ifitm3

• Natural killer (NK) cells from mice lyse murine teratocarcinoma stem cells in accordance with their appropriate cellular, genetic and interferon inducible features [1].
• The EST similar to rat P044, the EST similar to galectin-1, follistatin, annexin I, and the interferon-inducible gene 1-8U were also expressed in benign prostatic hyperplasia tissue [2].

High impact information on Ifitm3

• Best5: a novel interferon-inducible gene expressed during bone formation [3].
• The interferon-inducible RNA-specific adenosine deaminase (ADAR1) is an RNA-editing enzyme that catalyzes the deamination of adenosine in double-stranded RNA structures [4].
• The interferon-inducible RNA-specific adenosine deaminase (ADAR1) is an RNA editing enzyme implicated in the site-selective deamination of adenosine to inosine in cellular pre-mRNAs [5].
• Editing of glutamate receptor subunit B pre-mRNA by splice-site variants of interferon-inducible double-stranded RNA-specific adenosine deaminase ADAR1 [4].
• Interferon-inducible protein (IP)-10 is a small glycoprotein member of a family of chemotactic cytokines structurally related to interleukin-8 [6].

Biological context of Ifitm3

• Rat Mx2 and rat Mx3 are two alpha/beta interferon-inducible cytoplasmic GTPases that differ in three residues in the amino-terminal third, which also contains the tripartite GTP-binding domain, and that differ in five residues in the carboxy-terminal quarter, which also contains a dimerization domain [7].

Anatomical context of Ifitm3

• Interferon-inducible genes in the rat adrenal gland and vascular smooth muscle cells [8].
• An interferon-inducible molecule on brain endothelium which controls lymphocyte adhesion mediated by integrins [9].
• CONCLUSION: The Fragilis family of interferon-inducible genes is tightly associated with germ cell specification in mice [10].

Associations of Ifitm3 with chemical compounds

• The in vivo effects of methylxanthines on 2',5'-oligoadenylate (2,5An) synthetase activity, an interferon-inducible enzyme, were investigated in rat liver nuclei [11].

Other interactions of Ifitm3

• Eyes were harvested from both complement-sufficient and complement-depleted rats for mRNA and protein analysis for IFN-gamma, IL-10, and interferon-inducible protein (IP)-10 [12].
• Molecular cloning of a macrophage-derived, interferon-inducible secreted immunoglobulin-binding protein [13].
• We studied the effect of staurosporine on two well characterised mammalian eIF-2alpha kinases, the heme-regulated translational inhibitor (HRI), and interferon-inducible double-stranded RNA-activated protein kinase (PKR) [14].

References