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Gene Review

Tb927.5.4530  -  elongation of very long chain fatty acids...

Trypanosoma brucei brucei TREU927

 
 
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Disease relevance of Tb927.5.4530

 

High impact information on Tb927.5.4530

 

Biological context of Tb927.5.4530

  • Both enzymes share homology to the covalent nucleotidyl transferase superfamily and contain five key signature motifs, including the active site KXXG [7].
  • The potency of the compounds as inhibitors of cell proliferation was positively correlated with their efficacy as inhibitors of peptidyl transferase activity [8].
 

Anatomical context of Tb927.5.4530

 

Associations of Tb927.5.4530 with chemical compounds

 

Other interactions of Tb927.5.4530

  • Inosine diphosphatase, galactosyl transferase, acid phosphatase and acid phosphodiesterase sediment predominantly as microsomal constituents equilibrating at densities between 1.13 and 1.15 g/cm3 [11].

References

  1. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis. Buckner, F.S., Eastman, R.T., Yokoyama, K., Gelb, M.H., Van Voorhis, W.C. Current opinion in investigational drugs (London, England : 2000) (2005) [Pubmed]
  2. Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex. Schnaufer, A., Ernst, N.L., Palazzo, S.S., O'Rear, J., Salavati, R., Stuart, K. Mol. Cell (2003) [Pubmed]
  3. Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondria. Rusché, L.N., Cruz-Reyes, J., Piller, K.J., Sollner-Webb, B. EMBO J. (1997) [Pubmed]
  4. Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes. Vassella, E., Probst, M., Schneider, A., Studer, E., Renggli, C.K., Roditi, I. Mol. Biol. Cell (2004) [Pubmed]
  5. The effect of RNA interference Down-regulation of RNA editing 3'-terminal uridylyl transferase (TUTase) 1 on mitochondrial de novo protein synthesis and stability of respiratory complexes in Trypanosoma brucei. Nebohácová, M., Maslov, D.A., Falick, A.M., Simpson, L. J. Biol. Chem. (2004) [Pubmed]
  6. Differential response to RNA trans-splicing signals within the phosphoglycerate kinase gene cluster in Trypanosoma brucei. Kapotas, N., Bellofatto, V. Nucleic Acids Res. (1993) [Pubmed]
  7. Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei. McManus, M.T., Shimamura, M., Grams, J., Hajduk, S.L. RNA (2001) [Pubmed]
  8. Inhibition of Trypanosoma brucei brucei peptidyl transferase activity by sparsomycin analogs and effects on trypanosome protein synthesis and proliferation. Bitonti, A.J., Kelly, S.E., Flynn, G.A., McCann, P.P. Biochem. Pharmacol. (1985) [Pubmed]
  9. Inhibition of the GlcNAc transferase of the glycosylphosphatidylinositol anchor biosynthesis in African trypanosomes. Milne, K.G., Ferguson, M.A., Masterson, W.J. Eur. J. Biochem. (1992) [Pubmed]
  10. Purification and characterization of an alpha-galactosyltransferase from Trypanosoma brucei. Pingel, S., Rheinweiler, U., Kolb, V., Duszenko, M. Biochem. J. (1999) [Pubmed]
  11. Subcellular fractionation of Trypanosoma brucei bloodstream forms with special reference to hydrolases. Steiger, R.F., Opperdoes, F.R., Bontemps, J. Eur. J. Biochem. (1980) [Pubmed]
  12. Identification and characterisation of two N-acetylglucosaminyltransferases associated with Trypanosoma Brucei microsomes. Rovis, L., Dube, S. Mol. Biochem. Parasitol. (1982) [Pubmed]
  13. Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics. Lorente, S.O., Jimenez, C.J., Gros, L., Yardley, V., de Luca-Fradley, K., Croft, S.L., A Urbina, J., Ruiz-Perez, L.M., Pacanowska, D.G., Gilbert, I.H. Bioorg. Med. Chem. (2005) [Pubmed]
 
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