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Gene Review

BGLF4  -  BGLF4 protein

Human herpesvirus 4

 
 
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Disease relevance of BGLF4

 

High impact information on BGLF4

  • We also present evidence that BGLF4 interacts with and phosphorylates BZLF1, a key viral regulator of lytic infection [5].
  • (iv) BZLF1 was specifically coimmunoprecipitated with BGLF4 in 12-O-tetradecanoylphorbol-13-acetate-treated B95-8 cells and in COS-1 cells transiently expressing both of these viral proteins [5].
  • The Epstein-Barr virus (EBV) BGLF4 gene encodes a serine/threonine protein kinase (PK) that is expressed in the cytolytic cycle [6].
  • Nuclear localization could be visualized by indirect immunofluorescence in HeLa cells transiently expressing EBV BGLF4 in the absence of other viral products [7].
  • Virally encoded kinases (thymidine kinase and BGLF4) which are expressed only during the lytic form of infection convert GCV (a nucleoside analogue) into its active, cytotoxic form [8].
 

Chemical compound and disease context of BGLF4

  • Here we show that only one of these indolocarbazoles (K252a), but not maribavir, inhibits autophosphorylation of the EBV PK, BGLF4 [9].
 

Biological context of BGLF4

 

Associations of BGLF4 with chemical compounds

  • Manganese ions were found to be essential for autophosphorylation of BGLF4, and magnesium can stimulate the activity [4].
 

Other interactions of BGLF4

  • (v) BGLF4 and BZLF1 were colocalized in intranuclear globular structures, resembling the viral replication compartment, in Akata cells treated with anti-human immunoglobulin G [5].
  • Consistent with this, the EBV-encoded conserved protein kinase BGLF4 specifically mediated the phosphorylation of EBNA-LP at Ser-35 [11].

References

  1. Detection of Epstein-Barr virus BGLF4 protein kinase in virus replication compartments and virus particles. Wang, J.T., Yang, P.W., Lee, C.P., Han, C.H., Tsai, C.H., Chen, M.R. J. Gen. Virol. (2005) [Pubmed]
  2. ORF36 protein kinase of Kaposi's sarcoma herpesvirus activates the c-Jun N-terminal kinase signaling pathway. Hamza, M.S., Reyes, R.A., Izumiya, Y., Wisdom, R., Kung, H.J., Luciw, P.A. J. Biol. Chem. (2004) [Pubmed]
  3. Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1delta. Kawaguchi, Y., Kato, K., Tanaka, M., Kanamori, M., Nishiyama, Y., Yamanashi, Y. J. Virol. (2003) [Pubmed]
  4. A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro. Chen, M.R., Chang, S.J., Huang, H., Chen, J.Y. J. Virol. (2000) [Pubmed]
  5. Epstein-Barr virus protein kinase BGLF4 is a virion tegument protein that dissociates from virions in a phosphorylation-dependent process and phosphorylates the viral immediate-early protein BZLF1. Asai, R., Kato, A., Kato, K., Kanamori-Koyama, M., Sugimoto, K., Sairenji, T., Nishiyama, Y., Kawaguchi, Y. J. Virol. (2006) [Pubmed]
  6. Hyperphosphorylation of EBNA2 by Epstein-Barr virus protein kinase suppresses transactivation of the LMP1 promoter. Yue, W., Gershburg, E., Pagano, J.S. J. Virol. (2005) [Pubmed]
  7. Expression and localization of the Epstein-Barr virus-encoded protein kinase. Gershburg, E., Marschall, M., Hong, K., Pagano, J.S. J. Virol. (2004) [Pubmed]
  8. Lytic induction therapy for Epstein-Barr virus-positive B-cell lymphomas. Feng, W.H., Hong, G., Delecluse, H.J., Kenney, S.C. J. Virol. (2004) [Pubmed]
  9. Effects of maribavir and selected indolocarbazoles on Epstein-Barr virus protein kinase BGLF4 and on viral lytic replication. Gershburg, E., Hong, K., Pagano, J.S. Antimicrob. Agents Chemother. (2004) [Pubmed]
  10. Oxidative injury to endothelial cells due to Epstein-Barr virus-induced autoantibodies against manganese superoxide dismutase. Dalpke, A.H., Thomssen, R., Ritter, K. J. Med. Virol. (2003) [Pubmed]
  11. Identification of protein kinases responsible for phosphorylation of Epstein-Barr virus nuclear antigen leader protein at serine-35, which regulates its coactivator function. Kato, K., Yokoyama, A., Tohya, Y., Akashi, H., Nishiyama, Y., Kawaguchi, Y. J. Gen. Virol. (2003) [Pubmed]
 
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