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MeSH Review

Harvey murine sarcoma virus

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Disease relevance of Harvey murine sarcoma virus


High impact information on Harvey murine sarcoma virus


Chemical compound and disease context of Harvey murine sarcoma virus


Biological context of Harvey murine sarcoma virus

  • Transfection of normal human bronchial epithelial (NHBE) cells with a plasmid carrying the ras oncogene of Harvey murine sarcoma virus (v-Ha ras) changed the growth requirements, terminal differentiation, and tumorigenicity of the recipient cells [14].
  • This nucleotide binding property and other previously reported characteristics were similar to properties ascribed to the Harvey sarcoma virus src gene product. p20 also appeared similar to this src gene product when immunoprecipitates of both proteins were directly compared by one- and two-dimensional NaDodSO4 gel electrophoreses [3].
  • The transcriptional promoter of the Harvey sarcoma virus long terminal repeat has been used to construct a biologically active dihydrofolate reductase chimera [15].
  • By comparing these sequences with the Harvey murine sarcoma virus ras gene, we predict that the p21 protein encoded by the Harvey virus differs from the cellular c-rasH-1-encoded p21 at only two amino acids; those at positions 12 and 59 [16].
  • The majority of the rat-derived sequences present in the Harvey sarcoma virus genome can now be attributed exclusively to ras or retrovirus- or retrotransposon-related sequences [17].

Anatomical context of Harvey murine sarcoma virus


Gene context of Harvey murine sarcoma virus


  1. High-level expression in Escherichia coli of enzymatically active Harvey murine sarcoma virus p21ras protein. Lautenberger, J.A., Ulsh, L., Shih, T.Y., Papas, T.S. Science (1983) [Pubmed]
  2. Class II histocompatibility antigen expression in human melanocytes transformed by Harvey murine sarcoma virus (Ha-MSV) and Kirsten MSV retroviruses. Albino, A.P., Houghton, A.N., Eisinger, M., Lee, J.S., Kantor, R.R., Oliff, A.I., Old, L.J. J. Exp. Med. (1986) [Pubmed]
  3. A brain membrane protein similar to the rat src gene product. Scheinberg, D.A., Strand, M. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  4. Harvey-ras mediated neoplastic development in the mouse mammary gland. Strange, R., Aguilar-Cordova, E., Young, L.J., Billy, H.T., Dandekar, S., Cardiff, R.D. Oncogene (1989) [Pubmed]
  5. Anoxia-inducible rat VL30 elements and their relationship to ras-containing sarcoma viruses. Firulli, B.A., Anderson, G.R., Stoler, D.L., Estes, S.D. J. Virol. (1993) [Pubmed]
  6. The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid. Sefton, B.M., Trowbridge, I.S., Cooper, J.A., Scolnick, E.M. Cell (1982) [Pubmed]
  7. The p21 ras C-terminus is required for transformation and membrane association. Willumsen, B.M., Christensen, A., Hubbert, N.L., Papageorge, A.G., Lowy, D.R. Nature (1984) [Pubmed]
  8. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Parada, L.F., Tabin, C.J., Shih, C., Weinberg, R.A. Nature (1982) [Pubmed]
  9. Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Shih, T.Y., Papageorge, A.G., Stokes, P.E., Weeks, M.O., Scolnick, E.M. Nature (1980) [Pubmed]
  10. Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus. Willumsen, B.M., Norris, K., Papageorge, A.G., Hubbert, N.L., Lowy, D.R. EMBO J. (1984) [Pubmed]
  11. Direct identification of palmitic acid as the lipid attached to p21ras. Buss, J.E., Sefton, B.M. Mol. Cell. Biol. (1986) [Pubmed]
  12. The effect of viral transformation on prostaglandin production depends on cell type. Lin, M.C., Segawa, K., Ito, Y., Beckner, S.K. Virology (1986) [Pubmed]
  13. A synthetic peptide containing the autophosphorylation site of the transforming protein of Harvey sarcoma virus is phosphorylated by the EGF-stimulated tyrosine kinase. Baldwin, G.S., Stanley, I.J., Nice, E.C. FEBS Lett. (1983) [Pubmed]
  14. Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. Yoakum, G.H., Lechner, J.F., Gabrielson, E.W., Korba, B.E., Malan-Shibley, L., Willey, J.C., Valerio, M.G., Shamsuddin, A.M., Trump, B.F., Harris, C.C. Science (1985) [Pubmed]
  15. Construction and use of a dominant, selectable marker: a Harvey sarcoma virus-dihydrofolate reductase chimera. Murray, M.J., Kaufman, R.J., Latt, S.A., Weinberg, R.A. Mol. Cell. Biol. (1983) [Pubmed]
  16. Nucleotide sequence of the two rat cellular rasH genes. Ruta, M., Wolford, R., Dhar, R., Defeo-Jones, D., Ellis, R.W., Scolnick, E.M. Mol. Cell. Biol. (1986) [Pubmed]
  17. Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras. Manly, K.F., Anderson, G.R., Stoler, D.L. J. Virol. (1988) [Pubmed]
  18. Malignant transformation of mouse primary keratinocytes by Harvey sarcoma virus and its modulation by surrounding normal cells. Dotto, G.P., Weinberg, R.A., Ariza, A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  19. Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. Aran, J.M., Gottesman, M.M., Pastan, I. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  20. Infection of immune mast cells by Harvey sarcoma virus: immortalization without loss of requirement for interleukin-3. Rein, A., Keller, J., Schultz, A.M., Holmes, K.L., Medicus, R., Ihle, J.N. Mol. Cell. Biol. (1985) [Pubmed]
  21. Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family. Furth, M.E., Davis, L.J., Fleurdelys, B., Scolnick, E.M. J. Virol. (1982) [Pubmed]
  22. Characterization and developmental expression of a Drosophila ras oncogene. Mozer, B., Marlor, R., Parkhurst, S., Corces, V. Mol. Cell. Biol. (1985) [Pubmed]
  23. Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product. Weeks, M.O., Hager, G.L., Lowe, R., Scolnick, E.M. J. Virol. (1985) [Pubmed]
  24. An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors. Berlioz, C., Torrent, C., Darlix, J.L. J. Virol. (1995) [Pubmed]
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