Disease relevance of ATOH1

• Cosmology. Math trick may cause tension headache [1].
• In colon cancer cells, although Hath1 messenger RNA was also detected, Hath1 protein was positively degradated by proteasome-mediated proteolysis [2].
• Expression of Hath1 protein in colorectal cancers was examined by immunohistochemistry [2].
• Progression of these tumors is associated with the re-activation of the neuronal specific transcription factor Math1, dysregulation of Shh/Ptc1 signaling pathway, and chromosomal aberrations, including triradial and quadriradial chromosomes [3].
• The aim of this study was to assess the possible role of HATH1 in the development of mucinous cancers and signet ring carcinomas [4].

Psychiatry related information on ATOH1

• CONCLUSIONS: Math disorder and reading disorder + math disorder youngsters' lower sensitivity to sequence irregularity in their event-related potentials along with greater disruption of performance suggest working memory deficits that adversely affected response selection [5].
• Many children with Math LD do not have an associated reading disorder [6].
• A new 38-item Self Description Questionnaire for Preschoolers (SDQP) that measures 6 self-concept factors (Physical, Appearance, Peers, Parents, Verbal, and Math) was developed and tested [7].
• OBJECTIVE: To report the incidence of math learning disorder (Math LD) among school-aged children, overall and by gender [6].
• Math Concept and Math Problem-solving grade-placement scores did not differ by type of administration; teachers' ratings were higher than those produced by either testing format [8].

High impact information on ATOH1

• Subtracting the Math: prominin-positive cerebellar stem cells in white matter [9].
• Stability of Hath1 protein was analyzed by expression of FLAG-tagged Hath1 in human cell lines [2].
• BACKGROUND & AIMS: The transcription factor Hath1 plays a crucial role in the differentiation program of the human gut epithelium [2].
• Surprisingly, the GSK3beta-dependent protein degradation was switched between Hath1 and beta-catenin by Wnt signaling, leading to the dramatic alteration of cell status between proliferation and differentiation, respectively [2].
• METHODS: Tissue distribution of Hath1 messenger RNA in human tissues was examined by Northern blot [2].

Chemical compound and disease context of ATOH1

• A septicaemia Klebsiella pneumoniae isolate from Greece (Ath1) was shown to be resistant to third generation cephalosporins, aztreonam and cefoxitin and this resistance was not decreased in the presence of clavulanic acid [10].

Biological context of ATOH1

• Moreover, knockdown of Hath1 by means of RNA interference significantly decreased the expression of both mucin genes [11].
• Hath1 up-regulates gastric mucin gene expression in gastric cells [11].
• The mouse homolog (Math1) maps to mouse chromosome 6, and the human homolog (HATH1) to human chromosome 4q22 [12].
• We demonstrate a correlation between Brn-3c and HATH1 reactivity in MCC biopsies and cell lines with retention of neuroendocrine phenotype [13].
• In addition, transgenic mice with lacZ under the transcriptional control of MATH1-flanking DNA sequences express beta-galactosidase specifically in the developing nervous system, in a manner that mimics subsets of the MATH1-expression pattern, including the dorsal spinal neural tube [14].

Anatomical context of ATOH1

• The expression patterns of Hath1 and MUC6 were closely related in most GC cell lines [11].
• As for Hath1, five GC cell lines exhibited undetectable levels, while normal gastric mucosa expressed Hath1 [11].
• Recently, proper development of murine Merkel cells was shown to require the proneural basic helix-loop-helix transcription factor, atonal family member, MATH1 [13].
• Progenitors of dorsal commissural interneurons are defined by MATH1 expression [14].
• RESULTS: Hath1 messenger RNA expression was confined to the lower gastrointestinal tract in human adult tissues [2].

Associations of ATOH1 with chemical compounds

• New nonlinear evolution equations are derived that generalize those presented in a Letter by Matsuno [Phys. Rev. Lett. 69, 609 (1992)]] and a terrain-following Boussinesq system recently deduced by Nachbin [SIAM J Appl. Math. 63, 905 (2003)]] [15].
• The generation of new hair cells via Hath1 expression does not involve cell proliferation based on bromodeoxyuridine immunocytochemistry [16].
• More recently, fractal (Liebovitch et al. 1987. Math. Biosci. 84:37-68) and diffusion (Millhauser et al. 1988. Proc. Natl. Acad. Sci. USA. 85:1502-1507) models of channel gating have been proposed [17].
• The method of moments (Stoyan, 1990, Model. Biomet. J. 32, 843) used in EDMA (Lele, 1993, Math. Geol. 25, 573) exhibits larger errors [18].
• Plasma concentrations of d- and l-amphetamine, vital signs, teacher ratings of classroom behavior on the SKAMP, and 10-minute Math Test performance were measured repeatedly over 12 hours [19].

Other interactions of ATOH1

• We also analyzed the transactivation of MUC2 promoter/reporter constructs by a HATH1 expression vector [4].
• During phase 1, in the first week of differentiation, hath1 mRNA showed a small transient increase that correlated with the rapid accumulation of nestin message, a marker of neuroprogenitors [20].
• The transcription factors Math1 and Brn3.1 are required for hair cell differentiation, and supporting cells express negative regulators of neurogenesis, Hes1 and Hes5 [21].
• Although both factors induce neuronal differentiation, each factor has a distinct activity in the type of dorsal interneuron that forms, with overexpression of Math1 increasing dI1 interneurons, and Mash1 increasing dI3 interneurons [22].
• There were three valve-related deaths of a total of ten deaths (early 2; late 1) (TE 2; ATH 1; CVD 0; PVE 0; PPL 0; and SVD 0) [23].

Analytical, diagnostic and therapeutic context of ATOH1

• Using double-label immunofluorescence, we demonstrate that MATH1-expressing cells span both the proliferating and the differentiating zones within the dorsal neural tube, but within the EGL of the cerebellum are restricted to the proliferating zone [14].
• Sequence analysis revealed that the DEVPD30/G and WEID85/N sites lie within the highly conserved HATH (homologous to amino terminus of hepatoma-derived growth factor) region, also known as PWWP domain [24].
• Overexpression of Hath1 in HT29, an aggressive colon cancer cell line, resulted in a significant inhibition on cell proliferation, anchorage-independent growth in soft agar and, more importantly, growth of human colon cancer cell xenografts in athymic nude mice [25].
• Using a mass balance approach, the equations for an input-output model are derived and solved using Matlab (the Math Works Inc.). Changes in venous oxygenation are related to the results of fMRI experiments using progressively shorter periods of stimulation [26].
• Twenty-nine subjects (14 men, 15 women; 18--44 yr) were randomly assigned to either a control group or one of two stressor groups, Mental Math or Electric Shock. Subjects presented with Math and Shock stressors, which lasted 10 min, experienced significant increases in cognitive and physiological arousal compared with baseline and control subjects [27].

References