The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

AFF3  -  AF4/FMR2 family, member 3

Homo sapiens

Synonyms: AF4/FMR2 family member 3, LAF4, Lymphoid nuclear protein related to AF4, MLLT2-like, Protein LAF-4
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AFF3

  • We showed that the LAF4 gene on 2q11.2-12 was fused to the MLL gene on 11q23 in a pediatric patient with CD10 positive acute lymphoblastic leukemia (ALL) having t(2;11)(q11;q23) [1].
  • In a group of 64 primary human breast tumors, we found that LAF-4 was overexpressed in approximately 20% of the cases [2].

High impact information on AFF3

  • A novel human gene, LAF-4, was isolated from a subtracted cDNA library that showed strong sequence similarity to AF-4, a gene that is translocated in t(4;11)(q21;q23) acute lymphoblastic leukemias (ALLs) [3].
  • In mouse tissues, LAF-4 mRNA was found to be present at highest levels in lymphoid tissues, present at lower levels in brain and lung, and absent from other tissues [3].
  • In human and mouse lymphoid cell lines, LAF-4 expression was highest in pre-B cells, intermediate in mature B cells, and absent in plasma cells, thus pointing to a potential regulatory role for LAF-4 in lymphoid development [3].
  • These findings suggest that LAF4, AF4 and AF5q31 might define a new family particularly involved in the pathogenesis of 11q23-associated ALL [1].
  • The LAF4 gene, which encodes a lymphoid nuclear protein of 1227 amino acids with transactivation potential, is thought to have a role in early lymphoid development [1].

Biological context of AFF3


Anatomical context of AFF3


Other interactions of AFF3

  • Comparison of AF-4 protein coding sequences with the LAF-4 and FMR-2 sequences revealed five highly conserved domains of potential functional relevance [6].

Analytical, diagnostic and therapeutic context of AFF3


  1. Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23). Hiwatari, M., Taki, T., Taketani, T., Taniwaki, M., Sugita, K., Okuya, M., Eguchi, M., Ida, K., Hayashi, Y. Oncogene (2003) [Pubmed]
  2. LAF-4 is aberrantly expressed in human breast cancer. To, M.D., Faseruk, S.A., Gokgoz, N., Pinnaduwage, D., Done, S.J., Andrulis, I.L. Int. J. Cancer (2005) [Pubmed]
  3. LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Ma, C., Staudt, L.M. Blood (1996) [Pubmed]
  4. LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia. von Bergh, A.R., Beverloo, H.B., Rombout, P., van Wering, E.R., van Weel, M.H., Beverstock, G.C., Kluin, P.M., Slater, R.M., Schuuring, E. Genes Chromosomes Cancer (2002) [Pubmed]
  5. Occurrence of an MLL/LAF4 fusion gene caused by the insertion ins(11;2)(q23;q11.2q11.2) in an infant with acute lymphoblastic leukemia. Bruch, J., Wilda, M., Teigler-Schlegel, A., Harbott, J., Borkhardt, A., Metzler, M. Genes Chromosomes Cancer (2003) [Pubmed]
  6. Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia. Nilson, I., Reichel, M., Ennas, M.G., Greim, R., Knörr, C., Siegler, G., Greil, J., Fey, G.H., Marschalek, R. Br. J. Haematol. (1997) [Pubmed]
WikiGenes - Universities