Gene Review:
AFF2 - AF4/FMR2 family, member 2
Homo sapiens
Synonyms:
AF4/FMR2 family member 2, FMR2, FMR2P, FRAXE, Fragile X E mental retardation syndrome protein, ...
- Fragile XE-associated familial mental retardation protein 2 (FMR2) acts as a potent transcription activator. Hillman, M.A., Gecz, J. J. Hum. Genet. (2001)
- Association of Rickettsia helvetica with chronic perimyocarditis in sudden cardiac death. Nilsson, K., Lindquist, O., Påhlson, C. Lancet (1999)
- A study of FRAXE in mentally retarded individuals referred for fragile X syndrome (FRAXA) testing in the United Kingdom. Knight, S.J., Ritchie, R.J., Chakrabarti, L., Cross, G., Taylor, G.R., Mueller, R.F., Hurst, J., Paterson, J., Yates, J.R., Dow, D.J., Davies, K.E. Am. J. Hum. Genet. (1996)
- Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. Wittwer, F., van der Straten, A., Keleman, K., Dickson, B.J., Hafen, E. Development (2001)
- Localization of the fragile X mental retardation 2 (FMR2) protein in mammalian brain. Miller, W.J., Skinner, J.A., Foss, G.S., Davies, K.E. Eur. J. Neurosci. (2000)
- Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island. Gu, Y., Shen, Y., Gibbs, R.A., Nelson, D.L. Nat. Genet. (1996)
- FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability. Teague, J.W., Morton, N.E., Dennis, N.R., Curtis, G., McKechnie, N., Macpherson, J.N., Murray, A., Pound, M.C., Sharrock, A.J., Youings, S.A., Jacobs, P.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Distribution of FMR1 and FMR2 alleles in Javanese individuals with developmental disability and confirmation of a specific AGG-interruption pattern in Asian populations. Faradz, S.M., Leggo, J., Murray, A., Lam-Po-Tang, P.R., Buckley, M.F., Holden, J.J. Ann. Hum. Genet. (2001)
- Cytogenetic analysis of obsessive-compulsive disorder (OCD): identification of a FRAXE fragile site. Wang, Q., Gu, Y., Ferguson, J.M., Chen, Q., Boatwright, S., Gardiner, J., Below, C., Espinosa, J., Nelson, D.L., Shaffer, L.G. Am. J. Med. Genet. A (2003)
- Identification of the gene FMR2, associated with FRAXE mental retardation. Gecz, J., Gedeon, A.K., Sutherland, G.R., Mulley, J.C. Nat. Genet. (1996)
- Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE. Parrish, J.E., Oostra, B.A., Verkerk, A.J., Richards, C.S., Reynolds, J., Spikes, A.S., Shaffer, L.G., Nelson, D.L. Nat. Genet. (1994)
- Structural properties of lipopolysaccharides from Rickettsia typhi and Rickettsia prowazekii and their chemical similarity to the lipopolysaccharide from Proteus vulgaris OX19 used in the Weil-Felix test. Amano, K.I., Williams, J.C., Dasch, G.A. Infect. Immun. (1998)
- Structures of the O-antigens of Proteus bacilli belonging to OX group (serogroups O1-O3) used in Weil-Felix test. Ziolkowski, A., Shashkov, A.S., Swierzko, A.S., Senchenkova, S.N., Toukach, F.V., Cedzynski, M., Amano, K.I., Kaca, W., Knirel, Y.A. FEBS Lett. (1997)
- Structure of the acid-labile galactosyl phosphate-containing O-antigen of the bacterium Proteus vulgaris OX19 (serogroup O1) used in the Weil-Felix test. Senchenkova, S.N., Shashkov, A.S., Toukach, F.V., Ziolkowski, A., Swierzko, A.S., Amano, K.I., Kaca, W., Knirel YuA, n.u.l.l., Kochetkov, N.K. Biochemistry Mosc. (1997)
- A candidate gene for mild mental handicap at the FRAXE fragile site. Chakrabarti, L., Knight, S.J., Flannery, A.V., Davies, K.E. Hum. Mol. Genet. (1996)
- FMR2 expression in families with FRAXE mental retardation. Gécz, J., Oostra, B.A., Hockey, A., Carbonell, P., Turner, G., Haan, E.A., Sutherland, G.R., Mulley, J.C. Hum. Mol. Genet. (1997)
- Microdeletions in FMR2 may be a significant cause of premature ovarian failure. Murray, A., Webb, J., Dennis, N., Conway, G., Morton, N. J. Med. Genet. (1999)
- Characterisation and expression of a large, 13.7 kb FMR2 isoform. Gecz, J., Mulley, J.C. Eur. J. Hum. Genet. (1999)
- Expression of the murine homologue of FMR2 in mouse brain and during development. Chakrabarti, L., Bristulf, J., Foss, G.S., Davies, K.E. Hum. Mol. Genet. (1998)
- A rapid, non-radioactive screening test for fragile X mutations at the FRAXA and FRAXE loci. Wang, Q., Green, E., Bobrow, M., Mathew, C.G. J. Med. Genet. (1995)
- Serological response of patients suffering from primary and recrudescent typhus: comparison of complement fixation reaction, Weil-Felix test, microimmunofluorescence, and immunoblotting. Eremeeva, M.E., Balayeva, N.M., Raoult, D. Clin. Diagn. Lab. Immunol. (1994)
- Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice. Gu, Y., McIlwain, K.L., Weeber, E.J., Yamagata, T., Xu, B., Antalffy, B.A., Reyes, C., Yuva-Paylor, L., Armstrong, D., Zoghbi, H., Sweatt, J.D., Paylor, R., Nelson, D.L. J. Neurosci. (2002)
- FRAXE and mental retardation. Mulley, J.C., Yu, S., Loesch, D.Z., Hay, D.A., Donnelly, A., Gedeon, A.K., Carbonell, P., López, I., Glover, G., Gabarrón, I. J. Med. Genet. (1995)
- Implication of screening for FMR1 and FMR2 gene mutation in individuals with nonspecific mental retardation in Taiwan. Tzeng, C.C., Tzeng, P.Y., Sun, H.S., Chen, R.M., Lin, S.J. Diagn. Mol. Pathol. (2000)
- Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia. Nilson, I., Reichel, M., Ennas, M.G., Greim, R., Knörr, C., Siegler, G., Greil, J., Fey, G.H., Marschalek, R. Br. J. Haematol. (1997)
- Modulation of experimental allergic neuritis in rats by in vivo treatment with monoclonal anti T cell antibodies. Strigård, K., Olsson, T., Larsson, P., Holmdahl, R., Klareskog, L. J. Neurol. Sci. (1988)
- Does a peculiar EEG pattern exist also for FRAXE mental retardation? Musumeci, S.A., Scuderi, C., Ferri, R., Anello, G., Salluzzo, R., Bosco, P., Elia, M. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2000)